Corticotropin-Releasing Factor Receptor Antagonism within the Dorsal Raphe Nucleus Reduces Social Anxiety-Like Behavior after Early-Life Social Isolation: Influence Statistics

Expert Impact

Concepts for which they have has direct influence: Social isolation , Life social , Receptor antagonism , Anxiety behavior , Spraguedawley receptors , Social isolation rats , Social behavior .

Key People For Social Isolation

Top KOLs in the world
#1
John T Cacioppo
social neuroscience individual differences negativity bias
#2
Louise C Hawkley
social isolation chicago health age differences
#3
and Andrew Steptoe
depressive symptoms physical activity social isolation
#4
Julianne Holt‐Lunstad
social isolation cardiovascular reactivity mental health
#5
Timothy B Smith
ethnic identity social relationships racial attitudes
#6
Linda J Waite
aging project national social life social support

Corticotropin-Releasing Factor Receptor Antagonism within the Dorsal Raphe Nucleus Reduces Social Anxiety-Like Behavior after Early-Life Social Isolation

Abstract

. Social isolation of rats during the early part of development increases social anxiety-like behavior in adulthood. Furthermore, early-life social isolation increases the levels of corticotropin-releasing factor (CRF) receptors in the serotonergic dorsal raphe nucleus (dRN) of adult rats. Interactions between serotonin and CRF systems are thought to mediate anxiety behavior. Therefore, we investigated the effects of CRF receptor antagonism within the dRN on social anxiety-like behavior after early-life social isolation. Male rats were reared in isolation or in groups from weaning until midadolescence, and rehoused in groups and allowed to develop into adulthood. Adult rats underwent surgery to implant a drug cannula into the dRN. After recovery from surgery and acclimation to the testing arena, rats were infused with vehicle or the CRF receptor antagonist d-Phe-CRF((12-41)) (50 or 500 ng) into the dRN before a social interaction test. Isolation-reared rats pretreated with vehicle exhibited increased social anxiety-like behavior compared with rats reared in groups. Pretreatment of the dRN with d-Phe-CRF((12-41)) significantly reduced social anxiety-like behaviors exhibited by isolation-reared rats. Overall, this study shows that early-life social stress results in heightened social anxiety-like behavior, which is reversed by CRF antagonism within the dRN. These data suggest that CRF receptor antagonists could provide a potential treatment of stress-related social anxiety.