• Disease
  • Alcohol
  • Alcohol Dependence
  • Florian Naudet

    Prominent publications by Florian Naudet

    KOL Index score: 12448

    BACKGROUND AND AIMS: Pharmacologically controlled drinking in the treatment of alcohol dependence or alcohol use disorders (AUDs) is an emerging concept. Our objective was to explore the comparative effectiveness of drugs used in this indication.

    DESIGN: Systematic review with direct and network meta-analysis of double-blind randomized controlled trials (RCTs) assessing the efficacy of nalmefene, naltrexone, acamprosate, baclofen or topiramate in non-abstinent adults diagnosed with ...

    Also Ranks for: Alcohol Dependence |  nalmefene naltrexone |  controlled drinking |  health outcomes |  topiramate treatment
    KOL Index score: 10722

    BACKGROUND: To compare response to antidepressants between randomized controlled trials (RCTs) and observational trials.

    METHODS AND FINDINGS: Published and unpublished studies (from 1989 to 2009) were searched for by 2 reviewers on Medline, the Cochrane library, Embase, clinicaltrials.gov, Current Controlled Trial, bibliographies and by mailing key organisations and researchers. RCTs and observational studies on fluoxetine or venlafaxine in first-line treatment for major depressive ...

    Also Ranks for: Observational Studies |  randomized controlled trials |  major depressive disorder |  rcts treatment |  study characteristics
    KOL Index score: 10105

    BACKGROUND: Treatment of relapsed/refractory (R/R) primary CNS lymphoma (PCNSL) is poorly defined, because randomized trials and large studies are lacking. The aim of this study was to analyze the characteristics, management, and outcome of R/R PCNSL patients after first-line therapy in a nationwide cohort.

    METHODS: We analyzed R/R PCNSL patients following first-line treatment who had been prospectively registered in the database of the French network for oculocerebral lymphoma (LOC) ...

    Also Ranks for: Primary Cns Lymphoma |  pcnsl patients |  salvage therapy |  loc network |  relapsed refractory
    KOL Index score: 9674

    BACKGROUND: Nalmefene is a recent option in alcohol dependence treatment. Its approval was controversial. We conducted a systematic review and meta-analysis of the aggregated data (registered as PROSPERO 2014:CRD42014014853) to compare the harm/benefit of nalmefene versus placebo or active comparator in this indication.

    METHODS AND FINDINGS: Three reviewers searched for published and unpublished studies in Medline, the Cochrane Library, Embase, ClinicalTrials.gov, Current Controlled ...

    Also Ranks for: Alcohol Dependence |  nalmefene placebo |  randomized controlled trials |  sensitivity analyses |  consumption outcomes
    KOL Index score: 9542

    OBJECTIVES: To explore the effectiveness of data sharing by randomized controlled trials (RCTs) in journals with a full data sharing policy and to describe potential difficulties encountered in the process of performing reanalyses of the primary outcomes.

    DESIGN: Survey of published RCTs.

    SETTING: PubMed/Medline.

    ELIGIBILITY CRITERIA: RCTs that had been submitted and published by The BMJ and PLOS Medicine subsequent to the adoption of data sharing policies by these journals.


    Also Ranks for: Data Sharing |  randomized controlled trials |  primary outcomes |  rcts journals |  eligibility criteria
    KOL Index score: 9311

    OBJECTIVE: To evaluate the potential efficacy of mesenchymal stem cells (MSCs) in periodontal regeneration in humans on the following main outcomes: clinical attachment level (CAL), probing depth (PD), and gingival recession (GR).

    BACKGROUND: The clinical application of stem cells in periodontal regeneration has begun in recent years, but clinical practices are not yet standardized and no recommendations are available at this time.

    METHODS: Electronic database searches and hand searches ...

    Also Ranks for: Periodontal Regeneration |  mesenchymal stem cells |  randomized controlled |  attachment loss |  gingival recession
    KOL Index score: 8059

    OBJECTIVE: To evaluate the association between gifts from pharmaceutical companies to French general practitioners (GPs) and their drug prescribing patterns.

    DESIGN: Retrospective study using data from two French databases (National Health Data System, managed by the French National Health Insurance system, and Transparency in Healthcare).

    SETTING: Primary care, France.

    PARTICIPANTS: 41 257 GPs who in 2016 worked exclusively in the private sector and had at least five registered ...

    Also Ranks for: Pharmaceutical Companies |  outcome measures |  drug prescribing |  transparency healthcare |  general practitioners
    KOL Index score: 8016

    BACKGROUND: One of the main selection criteria of the quality of a liver graft is the degree of steatosis, which will determine the success of the transplantation. The aim of this study was to evaluate the ability of FibroScan and its related methods Controlled Attenuation Parameter and Liver Stiffness to assess objectively steatosis and fibrosis in livers from brain-dead donors to be potentially used for transplantation.

    METHODS: Over a period of 10 months, 23 consecutive brain dead ...

    Also Ranks for: Liver Stiffness |  controlled attenuation parameter |  steatosis assessment |  dead donors |  gold standard
    KOL Index score: 7905

    This pilot study was designed to assess the efficacy of low-frequency repetitive transcranial magnetic stimulation (rTMS) over the right orbitofrontal cortex (OFC) by means of a double-cone coil in patients suffering from obsessive-compulsive disorder. We hypothesized that low-frequency stimulation of the OFC would lead to a reduction in clinical symptoms, as measured on the Yale-Brown Obsessive Compulsive Scale (Y-BOCS). A randomized, double-blind, crossover design was implemented with ...

    Also Ranks for: Orbitofrontal Cortex |  compulsive disorder |  magnetic stimulation |  repetitive transcranial |  ybocs scores
    KOL Index score: 6552

    OBJECTIVE: This review aimed to investigate the therapeutic potential of Deep Brain Stimulation (DBS) for treating resistant Major Depressive Disorder (MDD). We explored the role of Nucleus accumbens (Nac) as a target for treatment.

    METHOD: We made a systematic review of all studies examining the mechanisms of action of high frequency brain stimulation and the pathophysiology of MDD. We also reported all the studies exploring the therapeutic potential of DBS in MDD.

    RESULTS: As a central ...

    Also Ranks for: Deep Brain Stimulation |  nucleus accumbens |  nac dbs |  depressive disorder |  depressed patients
    KOL Index score: 6361

    Androgen deprivation therapy (ADT) is a cornerstone therapy for advanced prostate cancer (PCa). We hypothesized that cardiovascular (CV) risk is different across the various ADT modalities to compare their effects on CV morbidity and mortality, and all-cause mortality in patients with PCa. To investigate more in depth potential CV risk heterogeneity focusing on coronary (main outcome) and cerebrovascular risk, CV, and overall mortality. We performed a Medline and Embase query, without ...

    Also Ranks for: Cardiovascular Risk |  observational studies |  androgen deprivation therapy |  randomized controlled trials |  prostate cancer
    KOL Index score: 6150

    Assessment of researchers is necessary for decisions of hiring, promotion, and tenure. A burgeoning number of scientific leaders believe the current system of faculty incentives and rewards is misaligned with the needs of society and disconnected from the evidence about the causes of the reproducibility crisis and suboptimal quality of the scientific publication record. To address this issue, particularly for the clinical and life sciences, we convened a 22-member expert panel workshop ...

    Also Ranks for: Promotion Tenure |  reproducibility crisis |  assessing scientists |  faculty humans |  current incentive
    KOL Index score: 6129

    High-frequency deep brain stimulation (DBS) represents a major stake for treatment for treatment-resistant depression (TRD). We describe a preliminary trial of DBS of two potential brain targets in chronic TRD: the nucleus accumbens (Acb) and, in the event of failure, the caudate nucleus. Patients were followed for 6 months before surgery (M0). From M1 to M5, they underwent stimulation of the Acb target. PET scans allowed us to track metabolic modifications resulting from this ...

    Also Ranks for: Brain Stimulation |  resistant depression |  nucleus accumbens |  emission tomography |  cingulate gyrus
    KOL Index score: 5882

    OBJECTIVE: To explore the implementation of the International Committee of Medical Journal Editors (ICMJE) data-sharing policy which came into force on 1 July 2018 by ICMJE-member journals and by ICMJE-affiliated journals declaring they follow the ICMJE recommendations.

    DESIGN: A cross-sectional survey of data-sharing policies in 2018 on journal websites and in data-sharing statements in randomised controlled trials (RCTs).

    SETTING: ICMJE website; PubMed/Medline.


    Also Ranks for: Data Sharing |  biomedical journals |  rcts published |  journal policies |  international committee
    KOL Index score: 5639

    We aimed to review and discuss the evidence-based arguments for the efficacy of electroconvulsive therapy (ECT) in the treatment of catatonia. Randomized controlled trials (RCTs) and observational studies focusing on the response to ECT in catatonia were selected in PubMed, the Cochrane Library, Embase, ClinicalTrials.gov and Current Controlled Trials through October 2016 and qualitatively described. Trials assessing pre-post differences using a catatonia or clinical improvement rating ...

    Also Ranks for: Electroconvulsive Therapy |  ect catatonia |  catatonic symptoms |  rating scale


    Florian Naudet: Influence Statistics

    Sample of concepts for which Florian Naudet is among the top experts in the world.
    Concept World rank
    transparency promotion #1

    Key People For Alcohol Dependence

    Top KOLs in the world
    Marc Alan Schuckit
    alcohol dependence collaborative study habitual smoking
    Bridget F Grant
    united states alcohol dependence personality disorders
    Henry R Kranzler
    alcohol dependence heavy drinking african americans
    Victor M Hesselbrock
    alcohol dependence collaborative study habitual smoking
    Kathleen Keenan Bucholz
    alcohol dependence parental separation conduct disorder
    John J I Nurnberger
    bipolar disorder alcohol dependence collaborative study

    Florian Naudet:Expert Impact

    Concepts for whichFlorian Naudethas direct influence:Alcohol dependence,  Randomized controlled trials,  Data sharing,  Observational studies,  Periodontal regeneration,  Transparency promotion,  Surgical journals,  Biomedical journals.

    Florian Naudet:KOL impact

    Concepts related to the work of other authors for whichfor which Florian Naudet has influence:Data sharing,  Deep brain stimulation,  Observational studies,  Major depressive disorder,  Nucleus accumbens,  Alcohol dependence,  Central nervous.



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    Univ Rennes, CHU Rennes, Inserm, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, F-35000, Rennes, France | Université de Rennes 1 - CHU Rennes, Inserm, Irset [(Institut de recherche en santé, environnement et travail)]