GlyTouCan 1.0 – The international glycan structure repository: Influence Statistics

Expert Impact

Concepts for which they have has direct influence: Glycan structure , Glycan structures , International glycan , Structure repository , Dna proteins , Glycans dna , Glycan databases .

Key People For Glycan Structure

Top KOLs in the world
#1
Pauline Mary Rudd
mass spectrometry rheumatoid arthritis protein glycosylation
#2
Raymond Allen Dwek
rheumatoid arthritis combining site endoplasmic reticulum
#3
Anne Dell
mass spectrometry mycobacterium tuberculosis carbohydrate sequence
#4
Ajit P Varki
sialic acids rat liver human evolution
#5
Nicolle H Packer
mass spectrometry gel electrophoresis glycan structures
#6
Hisashi Narimatsu
chondroitin sulfate liver fibrosis molecular cloning

GlyTouCan 1.0 – The international glycan structure repository

Abstract

. Glycans are known as the third major class of biopolymers, next to DNA and proteins. They cover the surfaces of many cells, serving as the 'face' of cells, whereby other biomolecules and viruses interact. The structure of glycans, however, differs greatly from DNA and proteins in that they are branched, as opposed to linear sequences of amino acids or nucleotides. Therefore, the storage of glycan information in databases, let alone their curation, has been a difficult problem. This has caused many duplicated efforts when integration is attempted between different databases, making an international repository for glycan structures, where unique accession numbers are assigned to every identified glycan structure, necessary. As such, an international team of developers and glycobiologists have collaborated to develop this repository, called GlyTouCan and is available at http://glytoucan.org/, to provide a centralized resource for depositing glycan structures, compositions and topologies, and to retrieve accession numbers for each of these registered entries. This will thus enable researchers to reference glycan structures simply by accession number, as opposed to by chemical structure, which has been a burden to integrate glycomics databases in the past.