HL-A Antigens in Acne Conglobata: A Negative Study: Influence Statistics

HL-A Antigens in Acne Conglobata: A Negative Study


. To the Editor.— The purpose of this study was to clarify the frequency of specific HL-A antigens in acne conglobata. Associations between the HL-A system and several diseases, including Hodgkin disease, ankylosing spondylitis, multiple sclerosis, psoriasis, pemphigus, myasthenia gravis, and celiac disease, have been reported.1,2In most of these diseases, there is evidence for the involvement of genetic factors. In view of the well-established role of inheritance in acne conglobata, we investigated the distribution of HL-A antigens in patients with acne conglobata and their families.Acne conglobata is a well-defined disease with a severe clinical course. The disease occurs in 5% of the male population and in somewhat less than 5% of the female population with acne.3 Investigators have fairly well established that heredity plays an important role in many cases of acne conglobata. The disease will often recur in several generations of a family, but the exact