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      In Young Choi

      In Young Choi

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      Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea | Department of Medical Informatics, College of ...

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      In Young Choi:Expert Impact

      Concepts for whichIn Young Choihas direct influence:Prostate cancer,South korea,Excessive smartphone,Pathologic myopia,User satisfaction,Microglial cells,Arden syntax,Glial cells.

      In Young Choi:KOL impact

      Concepts related to the work of other authors for whichfor which In Young Choi has influence:Stem cells,Oxidative stress,Problematic smartphone,Induced pluripotent,Neurodegenerative diseases,Parkinson disease,Prostate cancer.

      KOL Resume for In Young Choi

      Year
      2022

      Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea

      2021

      Total Healthcare Center, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea

      School of Medicine, Institute for Cell Engineering, Johns Hopkins University, 21205, Baltimore, MD, USA

      2020

      Department of Medicine, Graduate School, Kyung Hee University, Seoul, Republic of Korea

      The Institute for Cell Engineering, Johns Hopkins University, School of Medicine, Baltimore, United States

      2019

      Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Republic of Korea

      Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

      2018

      Department of Medical Informatics, College of Medicine, The Catholic University of Seoul, 222 Banpo-daero, Seocho-gu, Seoul 06591, Republic of Korea.

      Graduate School of Management and Policy

      2017

      The Catholic University of Korea, Seoul, Republic of Korea

      Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

      2016

      Department of Radiology and Research Institute of Radiology University of Ulsan, College of Medicine, Asan Medical Center Seoul Korea

      Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA

      2015

      From the Department of Internal Medicine (JML, JJH, SYK, SWJ, YKJ, JSK, HJY, HSL, SWL, CDK); and Department of Radiology (IYC, SKY), Korea University College of Medicine, Seoul, Korea.

      Korea University Ansan Hospital, Korea

      Institute for Cell Engineering, Department of Neurology, The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

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      Sample of concepts for which In Young Choi is among the top experts in the world.
      Concept World rank
      pva cbo #1
      perceived telemedicine #1
      humidity antimicrobial #1
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      cbo release rate #1
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      Prominent publications by In Young Choi

      KOL-Index: 14637

      Intracerebral hemorrhage (ICH) is a severe type of stroke causing neurological dysfunction with a high mortality rate. Dexmedetomidine is an agonist for α2‑adrenoreceptors with sedative, anxiolytic, analgesic and anesthetic effects. In the present study, we investigated the effects of dexmedetomidine on short‑term and spatial learning memory, as well as its effects on apoptosis following the induction of ICH in rats. A rat model of IHC was created by an injection of collagenase into the ...

      Known for Intracerebral Hemorrhage | Apoptosis Hippocampus | Neurotrophic Factor | Effects Dexmedetomidine | Memory Impairment
      KOL-Index: 14627

      OBJECTIVES: B-cell activating factor of the tumor necrosis factor family (BAFF) and a proliferation-inducing ligand (APRIL) regulate survival and proliferation of B cells. Thus the association of elevated serum levels of BAFF and APRIL with worse prognosis has been suggested in B-cell lymphoid malignancies. However, the prognostic relevance of BAFF and APRIL is unknown in patients treated with rituximab, a monoclonal antibody targeting B-cell depletion.

      METHODS: We measured serum levels ...

      Known for Serum Baff | Diffuse Large | Monoclonal Antibodies | Lymphoma Patients | Worse Prognosis
      KOL-Index: 14593

      Lipid membrane peroxidation is highly associated with neuronal death in various neurodegenerative diseases including cerebral stroke. Here, we report that simvastatin decreases oxygen and glucose deprivation (OGD)/reoxygenation-evoked neuronal death by inhibiting the production and cytoxicity of 4-hydroxy-2E-nonenal (HNE), the final product of lipid peroxidation. Simvastatin markedly decreased the OGD/reoxygenation-evoked death of cortical neurons. OGD/reoxygenation increased the ...

      Known for Cortical Neurons | Glucose Deprivation | Ogd Reoxygenation | Neuronal Cells | Spraguedawley Receptors
      KOL-Index: 13787

      OBJECTIVE: Advanced glycation end products (AGE) accumulate in articular cartilage with age. We investigated the effects of AGE in primary-cultured human OA chondrocytes.

      METHODS: Chondrocytes were cultured with/or without AGE-bovine serum albumin (AGE-BSA) and the expression levels of inducible nitric oxide (iNOS), cyclooxygenase (COX)-2 microsomal prostaglandin E synthase-1 (mPGES-1) were evaluated using RT-PCR and western blot analysis. Prostaglandin E(2) (PGE(2)) was analysed by ...

      Known for Advanced Glycation | Articular Cells | Age Rage | Pge2 Levels | Nitric Oxide
      KOL-Index: 12875

      Recently, matrix metalloproteinases (MMPs) are emerging as important molecules in neuroinflammation as well as neuronal cell death. However, the role of MMPs in activated microglia remains unclear. In the present study, we found that expressions of MMP-1, -3, -8 and -9 were significantly induced by single or combined treatment of immunostimulants lipopolysaccharide (LPS) or phorbol myristate acetate (PMA) in primary cultured microglia and BV2 microglial cells. Inhibition of MMP-3 or -9 ...

      Known for Proinflammatory Cytokines | Expression Mmp3 | Activated Microglia | Role Mmps | 3 Matrix Metalloproteinase
      KOL-Index: 12732

      The type 2 cannabinoid receptor (CB2R) was recently shown to mediate neuroprotection in ischemic injury. However, the role of CB2Rs in the central nervous system, especially neuronal and glial CB2Rs in the cortex, remains unclear. We, therefore, investigated anti-ischemic mechanisms of cortical CB2R activation in various ischemic models. In rat cortical neurons/glia mixed cultures, a CB2R agonist, trans-caryophyllene (TC), decreased neuronal injury and mitochondrial depolarization caused ...

      Known for Cerebral Ischemic | Cb2 Receptor | Protein Creb | Cannabinoid Rats | Neuronal Injury
      KOL-Index: 10510

      In order for human embryonic stem cells (hESCs) to be cultured on mouse embryonic fibroblast (MEFs) feeder cells, continuous basic fibroblast growth factor (bFGF) supplementation is required. However, the role of bFGF in a culture system using human-derived feeder cells has not been evaluated until now. In this study, we propagated the widely used hESC lines, H1 and HSF6, on human placenta-derived feeder cells (HPCs) without exogenous bFGF supplementation, and were able to propagate ...

      Known for Undifferentiated Propagation | Feeder Cells | Stem Cell | Human Embryonic | Fibroblast Growth
      KOL-Index: 10027

      PURPOSE: Despite the proliferation of telemedicine technology, telemedicine service acceptance has been slow in actual healthcare settings. The purpose of this research is to develop a theoretical model for explaining the predictive factors influencing physicians' willingness to use telemedicine technology to provide healthcare services.

      METHODS: We developed the Telemedicine Service Acceptance model based on the technology acceptance model (TAM) with the inclusion of three predictive ...

      Known for Behavioral Intention | Predictive Factors | Telemedicine Technology | Perceived Ease | Acceptance Model
      KOL-Index: 9635

      Dopamine receptor subtypes D1 and D2, and many other seven-transmembrane receptors including adenosine receptor A2A, are colocalized in striatum of brain. These receptors stimulate or inhibit adenylyl cyclases (ACs) to produce distinct physiological and pharmacological responses and interact with each other synergistically or antagonistically at various levels. The identity of the AC isoform that is coupled to each of these receptors, however, remains unknown. To investigate the in vivo ...

      Known for Dopamine Receptor | Ac5 Striatum | Type 5 | Adenylyl Cyclases | Motor Activity
      KOL-Index: 9561

      Given that tea contains a number of chemical constituents possessing medicinal and pharmacological properties, green tea seed is also believed to contain many biologically active compounds such as saponin, flavonoids, vitamins, and oil materials. However, little is known about the physiologic functions of green tea seed oil. The aim of this study is to investigate the anti-obesity effects of green tea seed oil in C57BL/6J mice and in preadipocyte 3T3L-1 cell lines. In vivo, three groups ...

      Known for Tea Seed | Adipocyte Differentiation | Weight Gain | Total Cholesterol | Antiobesity Effects
      KOL-Index: 9352

      In the culture system using human feeder cells, the mechanism through which these cells support undifferentiated growth of embryonic stem cells (ESCs) has not been well investigated. Here, we explored the mechanisms of 3 kinds of human feeder cells, including human placental cells from the chorionic plate, human bone marrow stromal cells, and human foreskin fibroblasts. First, we determined that undifferentiated growth of 2 kinds each of human (H1 and HSF6) and mouse (D3 and CE3) ESCs ...

      Known for Feeder Cells | Embryonic Stem | Growth Factor | Basic Fibroblast | Human Escs
      KOL-Index: 9168

      We investigated the effects of advanced glycation end products (AGE) which accumulate in articular cartilage with age in human osteoarthritic chondrocytes. We found AGE-BSA significantly increased MMP-1, -3, and -13, and TNF-alpha in a dose-dependent manner. AGE-BSA-stimulated JNK, p38, and ERK and NF-kappaB activity. The stimulatory effect of AGE-BSA on MMP-1, -3, and -13 were reversed by treatment with specific JNK, p38 inhibitors, suggesting JNK and p38 are involved in AGE-BSA-induced ...

      Known for Matrix Metalloproteinase | Advanced Glycation | Human Osteoarthritic | Age Bsa | Soluble Receptor
      KOL-Index: 9042

      In intracerebral hemorrhage, microglia become rapidly activated and remove the deposited blood and cellular debris. To survive in a harmful hemorrhagic or posthemorrhagic condition, activated microglia must be equipped with appropriate self-defensive mechanism(s) to resist the toxicity of hemin, a component released from damaged RBCs. In the current study, we found that activation of microglia by pretreatment with LPS markedly reduced their vulnerability to hemin toxicity in vitro. ...

      Known for Activated Microglia | P38 Mapk | Nitric Oxide | Inos Inhibitor | Intracerebral Hemorrhage
      KOL-Index: 8941

      OBJECTIVE: To explore the efficacy, safety, and tolerability of once-weekly efpeglenatide, a long-acting glucagon-like peptide 1 receptor agonist (GLP-1 RA), in early type 2 diabetes (T2D) (drug naive or on metformin monotherapy).

      RESEARCH DESIGN AND METHODS: EXCEED 203 was a 12-week, randomized, placebo-controlled, double-blind, parallel-group, dose-ranging study of efpeglenatide once weekly referenced to open-label liraglutide 1.8 mg (exploratory analysis). Participants, ∼90% on ...

      Known for Type 2 | Glycemic Control | Weekly Efpeglenatide | Placebo Hba1c | Weight Diabetes
      KOL-Index: 8911

      The mutation or overexpression of alpha-synuclein protein plays a pivotal role in the pathogenesis of Parkinson's disease. In our preliminary experiments, we found that alpha-synuclein induced the expression of matrix metalloproteinases (MMPs) (MMP-1, -3, -8, and -9) in rat primary cultured microglia. Thus, the current study was undertaken to determine the roles of MMPs in alpha-synuclein-induced microglial activation. The inhibition of MMP-3, -8, or -9 significantly reduced NO and ...

      Known for Tumor Cells | Matrix Metalloproteinases Mmps | Alpha Synuclein | Parkinsons Disease | Cultured Microglia

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      Department of Biomedicine & Health Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea | Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea;, sjpark2029@gmail.c

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