Prominent publications by Kenneth K K Wang

KOL Index score: 12808

BACKGROUND: Barrett's esophagus, a condition of intestinal metaplasia of the esophagus, is associated with an increased risk of esophageal adenocarcinoma. We assessed whether endoscopic radiofrequency ablation could eradicate dysplastic Barrett's esophagus and decrease the rate of neoplastic progression.

METHODS: In a multicenter, sham-controlled trial, we randomly assigned 127 patients with dysplastic Barrett's esophagus in a 2:1 ratio to receive either radiofrequency ablation (ablation ...

Also Ranks for: Radiofrequency Ablation |  complete eradication dysplasia |  intestinal metaplasia |  dysplastic barretts esophagus |  neoplastic progression
KOL Index score: 10759

BACKGROUND AND AIMS: Previous estimates of incidence of intestinal metaplasia (IM) recurrence after achieving complete remission of IM (CRIM) through endoscopic therapy of Barrett's esophagus (BE) have varied widely. We performed a systematic review and meta-analysis of studies to estimate an accurate recurrence risk after CRIM.

METHODS: We performed a systematic search of multiple literature databases through June 2015 to identify studies reporting long-term follow-up after achieving ...

Also Ranks for: Endoscopic Therapy |  recurrence crim |  hgd eac |  barrett esophagus |  complete remission
KOL Index score: 7746

PURPOSE: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive disease, affecting children and adults. Chemotherapy treatments show high response rates but have debilitating effects and carry risk of relapse. Previous work implicated NOTCH1 and other oncogenes. However, direct inhibition of these pathways affects healthy tissues and cancer alike. Our goal in this work has been to identify enzymes active in T-ALL whose activity could be targeted for therapeutic ...

Also Ranks for: Cell Leukemia |  usp7 tall |  ubiquitin specific |  expression regulation |  xenograft model
KOL Index score: 7011

Esophageal adenocarcinoma risk in Barrett's esophagus (BE) is increased 30- to 125-fold versus the general population. Among all BE patients, however, neoplastic progression occurs only once per 200 patient-years. Molecular biomarkers are therefore needed to risk-stratify patients for more efficient surveillance endoscopy and to improve the early detection of progression. We therefore performed a retrospective, multicenter, double-blinded validation study of eight BE progression ...

Also Ranks for: Methylation Biomarkers |  neoplastic progression |  early detection |  barretts esophagus |  roc curve
KOL Index score: 6583

This article reviews progress in chemopreventive drug development, especially data and concepts that are new since the 2002 AACR report on treatment and prevention of intraepithelial neoplasia. Molecular biomarker expressions involved in mechanisms of carcinogenesis and genetic progression models of intraepithelial neoplasia are discussed and analyzed for how they can inform mechanism-based, molecularly targeted drug development as well as risk stratification, cohort selection, and ...

Also Ranks for: Intraepithelial Neoplasia |  drug development |  risk stratification |  new agents |  molecular biomarkers
KOL Index score: 3879

BACKGROUND: Probe-based confocal laser endomicroscopy (pCLE) provides microscopic imaging during an endoscopic procedure. Its introduction as a standard modality in gastroenterology has brought significant progress in management strategies, affecting many aspects of clinical care and requiring standardisation of practice and training.

OBJECTIVE: This study aimed to provide guidance on the standardisation of its practice and training in Barrett's oesophagus, biliary strictures, colorectal ...

Also Ranks for: Consensus Report |  confocal laser |  diagnostic performance |  endoscopic procedure |  modified delphi approach
KOL Index score: 3768

BACKGROUND & AIMS: Tethered capsule endomicroscopy (TCE) involves swallowing a small tethered pill that implements optical coherence tomography (OCT) imaging, procuring high resolution images of the whole esophagus. Here, we demonstrate and evaluate the feasibility and safety of TCE and a portable OCT imaging system in patients with Barrett's esophagus (BE) in a multi-center (5-site) clinical study.

METHODS: Untreated patients with BE as per endoscopic biopsy diagnosis were eligible to ...

Also Ranks for: Tethered Capsule |  oct tce |  unsedated patients |  barrett esophagus |  optical coherence tomography
KOL Index score: 1691
Also Ranks for: Updated Guidelines |  diagnosis surveillance |  esophagus barrett
KOL Index score: 210

Improvements in narrow band imaging (NBI) may provide an improved view of colonic mucosa for detection of polyps and adenomas. In this issue, Leung et al. report findings to suggest that this next-generation NBI technology is superior to conventional high-definition white light endoscopy in polyp detection. These findings are based on brighter illumination, which has been a problem with older generations of NBI, which did not increase polyp detection but were useful for polyp ...

Also Ranks for: Narrow Band

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Kenneth K K Wang:Expert Impact

Concepts for whichKenneth K K Wanghas direct influence:Intraepithelial neoplasia,  Endoscopic therapy,  Radiofrequency ablation,  Tethered capsule,  Patients ablation,  Methylation biomarkers,  Barretts esophagus,  Recurrence crim.

Kenneth K K Wang:KOL impact

Concepts related to the work of other authors for whichfor which Kenneth K K Wang has influence:Barrett esophagus,  Esophageal adenocarcinoma,  Radiofrequency ablation,  Intestinal metaplasia,  Endoscopic resection,  Grade dysplasia,  Neoplastic progression.



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Department of Gastroenterology, Mayo Clinic, Rochester, Minnesota. | Barrett's Esophagus Unit, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota. | Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minn