 | Mengqin ZhuSchool of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, Jiangsu, China. | Department of Pharmaceutics, School of Pharmaceutical Sciences, Jiangnan University, ... |
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Mengqin Zhu:Expert Impact
Concepts for whichMengqin Zhuhas direct influence:Cellular uptake,Doxorubicin resistance,Hod micelles,Dox hod,Hyaluronic acid,Dox hod micelles,Micelles dox,Mdr dnvm.
Mengqin Zhu:KOL impact
Concepts related to the work of other authors for whichfor which Mengqin Zhu has influence:Polymeric micelles,Hyaluronic acid,Cellular uptake,Chemotherapeutic agents,Specific biomolecules,Natural biopolymers,Dox release.
KOL Resume for Mengqin Zhu
| Year | |
|---|---|
| 2021 | School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, Jiangsu, China. |
| 2017 | Department of Pharmaceutics, School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, PR China |
| 2016 | School of Pharmaceutical Sciences Jiangnan University Wuxi 214122 PR China |
| Concept | World rank |
|---|---|
| acid2octadecyloxy13 dioxan5 | #3 |
| hyaluronic acid2octadecyloxy13 | #3 |
| acid2octadecyloxy13 | #3 |
| amine hod | #4 |
| hod micelles | #4 |
| dioxan5 amine | #4 |
| dox hod micelles | #4 |
| loaded hod micelles | #5 |
| acidinsensitive doxves | #5 |
| ves loaded | #5 |
| dnvm synergistically | #5 |
| gain dnvm | #5 |
| mdr reversal dnvm | #5 |
| ves prodrug | #5 |
| developed dnvm | #5 |
| caveolaemediated routes | #5 |
| dnvm efficacy | #5 |
| double gain dnvm | #5 |
| dnvm mdr | #5 |
| doxloaded hod micelles | #5 |
| ves sensitive | #5 |
| dox hod dox | #5 |
| dox vitamin succinate | #5 |
| doxnnves prodrug | #5 |
| reversal dnvm | #5 |
| loaded hod | #5 |
| mdr dnvm | #5 |
| phinduced degradable | #5 |
| dnvm reversal | #5 |
| dox hod | #5 |
| 2octadecyloxy13dioxan5amine | #5 |
| dnvm inhibited | #5 |
| potential tumor mdr | #5 |
| dnvm dox | #5 |
| dox dox hod | #5 |
| sensitive hod | #5 |
| presented dox | #6 |
| function prodrug | #7 |
| nonsensitive micelles | #8 |
| hod studies | #9 |
| hyaluronic acid micelles | #9 |
| dox ves | #10 |
| endocytosis inhibition studies | #10 |
| dox vitamin | #11 |
| chemotherapeutics potential | #12 |
| dnvm | #13 |
| hoa micelles | #13 |
| drugconjugate | #15 |
| mice hod | #16 |
| micelles endocytosis | #20 |
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Prominent publications by Mengqin Zhu
2-(Octadecyloxy)-1,3-dioxan-5-amine (OD) with an acid degradable ortho ester group was synthesized, and conjugated to hyaluronic acid (HA) backbone to prepare pH-responsive and tumor-targeted hyaluronic acid-2-(octadecyloxy)-1,3-dioxan-5-amine (HOD) conjugates. 1H NMR was used to confirm the structures of the OD and HOD. The studies of pH-responsive behavior showed that HOD micelles were stable under physiological conditions while they were degraded in the tumor acidic microenvironment. ...
| Known for Tumor Drug | Hod Micelles | Mcf7 Cells | Physiological Conditions | Vitro Cytotoxicity |
Mechanisms of cellular uptake with hyaluronic acid—octadecylamine micelles as drug delivery nanocarriers
[ PUBLICATION ]
DOX/HM23, based on appropriate DS and proper particle size, presented enhanced anticancer activity and efficient internalization to achieve the highest intracellular drug concentration.
Plenty of hyaluronic acid (HA) drug delivery systems have been developed to target cancer cells. Carboxyl of HA is the active group for targeting CD44 receptor, which is overexpressed in several different types of cancer cells. To verify whether the number of carboxyl is the main ...
| Known for Drug Delivery | Hyaluronic Acid | Cancer Cells | Micelles Dox | Cd44 Receptor |
Decoration of pH-sensitive copolymer micelles with tumor-specific peptide for enhanced cellular uptake of doxorubicin
[ PUBLICATION ]
To improve the targeting efficacy of hyaluronic acid (HA)-based micelles, pH-sensitive mixed micelles based on HA-g-poly(L-histidine) (PHis) and d-α-tocopheryl polyethylene glycol 2000 copolymers were prepared and decorated with human epidermal growth factor receptor 2 (Her2) peptide, a tumor cell-specific peptide ligand, on their surface. The doxorubicin-loaded micelles (HA-PHis/peptide-d-α-tocopheryl polyethylene glycol 2000 mixed micelles [PHTM]) were characterized to have a unimodal ...
| Known for Cellular Uptake | Specific Peptide | Hyaluronic Acid | Drug Carriers | Receptor Erbb2 |
Stimuli-responsive, dual-function prodrug encapsulated in hyaluronic acid micelles to overcome doxorubicin resistance
[ PUBLICATION ]
Multidrug resistance (MDR) is the main challenge faced by cancer chemotherapy. Drug-conjugate offers a promising strategy for breast cancer therapy. In this regard, we developed a DNVM multifunctional drug delivery system by crosslinking doxorubicin (DOX) and vitamin E succinate (VES) with a pH-sensitive hydrazone bond and then encapsulated the DOX-NN-VES prodrug into pH-sensitive hyaluronic acid-2-(octadecyloxy)-1,3-dioxan-5-amine (HOD) micelles. DOX resistant MCF-7/ADR cell were ...
| Known for Hyaluronic Acid | Cancer Therapy | Stimuli Responsive |
