Prominent publications by Nicholas James Shaheen

KOL Index score: 17974

BACKGROUND & AIMS: The goal of treatment for Barrett's esophagus (BE) with dysplasia is complete eradication of intestinal metaplasia (CEIM). The long-term durability of CEIM has not been well characterized, so the frequency and duration of surveillance are unclear. We report results from a 5-year follow-up analysis of patients with BE and dysplasia treated by radiofrequency ablation (RFA) in the randomized controlled Ablation of Intestinal Metaplasia Containing Dysplasia (AIM) ...

Also Ranks for: Intestinal Metaplasia |  complete eradication |  ceim patients |  dysplasia recurrence |  ablation rfa
KOL Index score: 17845

BACKGROUND & AIMS: Distinguishing between eosinophilic esophagitis (EoE), gastroesophageal reflux disease, and proton pump inhibitor-responsive esophageal eosinophilia (PPI-REE) is challenging. We assessed whether immunohistochemical analysis of esophageal tissues for major basic protein (MBP), eotaxin-3, and tryptase can be used for diagnosis of EoE and to differentiate EoE from PPI-REE.

METHODS: We conducted a prospective study of 196 consecutive adults who underwent outpatient ...

Also Ranks for: Patients Eoe |  eosinophilic esophagitis |  proton pump inhibitor |  responsive esophageal |  ppi ree
KOL Index score: 16870

OBJECTIVES: Proton-pump inhibitor-responsive esophageal eosinophilia (PPI-REE) is a newly recognized entity that must be differentiated from eosinophilic esophagitis (EoE). Little is known about this condition. We aimed to determine the prevalence of PPI-REE and EoE in patients undergoing upper endoscopy and determine features that distinguish the two groups.

METHODS: This prospective study conducted at the University of North Carolina from 2009 to 2011 enrolled consecutive adult ...

Also Ranks for: Eosinophilic Esophagitis |  upper endoscopy |  eoe patients |  eos hpf |  ppi trial
KOL Index score: 16563

CONTEXT: Gastroesophageal reflux disease (GERD) is a risk factor for adenocarcinoma of the esophagus, a rare cancer whose incidence is increasing. Adenocarcinoma may develop from Barrett esophagus, a metaplastic change of the esophageal epithelium from squamous to intestinalized columnar mucosa, which is associated with chronic reflux. Some have recommended that patients with chronic reflux symptoms undergo upper endoscopy to assess for Barrett esophagus and to screen for ...

Also Ranks for: Barrett Esophagus |  gastroesophageal reflux |  esophageal cancer |  risk adenocarcinoma |  upper endoscopy
KOL Index score: 15862

A mainstay of strategies to prevent HIV-1 transmission is to use antiretroviral therapy (ART) for pre-exposure prophylaxis (PrEP). Critical to the design and interpretation of PrEP prevention trials is the ability to make accurate pharmacological measurements of ART drugs in human genital and colorectal mucosal tissues, the principal route of HIV transmission. Here, we evaluated two drugs that are preferentially used for PrEP: tenofovir (TFV) disoproxil fumarate (TDF) and emtricitabine ...

Also Ranks for: Tfv Ftc |  mucosal tissues |  blood plasma |  genital secretions |  tenofovir emtricitabine
KOL Index score: 15858

BACKGROUND: EMR is commonly performed before radiofrequency ablation (RFA) for nodular dysplastic Barrett's esophagus (BE).

OBJECTIVE: To determine the efficacy and safety of EMR before RFA for nodular BE with advanced neoplasia (high-grade dysplasia [HGD] or intramucosal carcinoma [IMC]).

DESIGN: Retrospective study.

SETTING: University of North Carolina Hospitals, from 2006 to 2011.

PATIENTS: 169 patients with BE with advanced neoplasia: 65 patients treated with EMR and RFA for nodular ...

Also Ranks for: Radiofrequency Ablation |  advanced neoplasia |  patients rfa |  complete eradication |  hgd imc
KOL Index score: 15341

OBJECTIVES: Mast cells may contribute to the pathogenesis of eosinophilic esophagitis (EoE), but their role in diagnosis is unknown. Our aim was to determine whether tryptase staining of esophageal mast cells differentiates EoE from gastroesophageal reflux disease (GERD) and has utility for diagnosis of EoE.

METHODS: We performed a case-control study comparing patients with EoE, defined by consensus guidelines, to GERD patients with eosinophils on esophageal biopsy. Immunohistochemistry ...

Also Ranks for: Mast Cells |  gastroesophageal reflux disease |  eosinophilic esophagitis |  patients eoe |  tryptase staining
KOL Index score: 14890

BACKGROUND & AIMS: Radiofrequency ablation (RFA) can eradicate dysplasia and intestinal metaplasia in patients with dysplastic Barrett's esophagus (BE), and reduce rates of esophageal adenocarcinoma. We assessed long-term rates of eradication, durability of neosquamous epithelium, disease progression, and safety of RFA in patients with dysplastic BE.

METHODS: We performed a randomized trial of 127 subjects with dysplastic BE; after cross-over subjects were included, 119 received RFA. ...

Also Ranks for: Dysplasia Intestinal Metaplasia |  radiofrequency ablation |  rfa patients |  2 years |  esophageal adenocarcinoma
KOL Index score: 14743

BACKGROUND: Oesophageal adenocarcinoma represents one of the fastest rising cancers in high-income countries. Barrett's oesophagus is the premalignant precursor of oesophageal adenocarcinoma. However, only a few patients with Barrett's oesophagus develop adenocarcinoma, which complicates clinical management in the absence of valid predictors. Within an international consortium investigating the genetics of Barrett's oesophagus and oesophageal adenocarcinoma, we aimed to identify novel ...

Also Ranks for: Oesophageal Adenocarcinoma |  barretts oesophagus |  north america |  × 10 |  genome wide
KOL Index score: 14495

BACKGROUND & AIMS: Cigarette smoking has been implicated in the etiology of esophageal adenocarcinoma, but it is not clear if smoking is a risk factor for Barrett's esophagus. We investigated whether tobacco smoking and other factors increase risk for Barrett's esophagus.

METHODS: We analyzed data from 5 case-control studies included in the international Barrett's and Esophageal Adenocarcinoma Consortium. We compared data from subjects with Barrett's esophagus (n = 1059) with those from ...

Also Ranks for: Cigarette Smoking |  barretts esophagus |  esophageal adenocarcinoma |  risk barrett |  heartburn regurgitation
KOL Index score: 14011

OBJECTIVES: Features of eosinophilic esophagitis (EoE) and gastroesophageal reflux disease (GERD) overlap. We aimed to determine whether staining for tissue biomarkers would differentiate EoE from GERD, suggesting utility for diagnosis of EoE.

METHODS: In this case-control study, EoE patients defined by consensus guidelines were compared to GERD patients with eosinophils on esophageal biopsy. Immunohistochemistry was performed for major basic protein (MBP), eotaxin-3, leukotriene A4 ...

Also Ranks for: Eosinophilic Esophagitis |  diagnostic utility |  major basic protein |  diagnosis eoe |  eosinophil count
KOL Index score: 13937

BACKGROUND & AIMS: Eosinophilic esophagitis (EoE) is of increasing prevalence and believed to result from allergic processes. Helicobacter pylori has been inversely associated with allergic diseases, but there is no known relationship between H pylori, EoE, and esophageal eosinophilia. We investigated the association between esophageal eosinophilia and H pylori infection.

METHODS: We performed a cross-sectional study of data, collected from a US pathology database, on 165,017 patients in ...

Also Ranks for: Esophageal Eosinophilia |  helicobacter pylori |  pathology database |  inverse association |  eosinophilic esophagitis eoe
KOL Index score: 13899

The effects of preceding endoscopic mucosal resection (EMR) on the efficacy and safety of radiofrequency ablation (RFA) for treatment of nodular Barrett's esophagus (BE) is poorly understood. Prior studies have been limited to case series from individual tertiary care centers. We report the results of a large, multicenter registry. We assessed the effects of preceding EMR on the efficacy and safety of RFA for nodular BE with advanced neoplasia (high-grade dysplasia or intramucosal ...

Also Ranks for: Emr Rfa |  complete eradication |  efficacy safety |  barrett esophagus |  mucosal resection
KOL Index score: 13895

BACKGROUND & AIMS: For patients with Barrett's esophagus, the diagnosis of low-grade dysplasia (LGD) is subjective, and reported outcomes vary. We analyzed data from a multicenter study of endoscopic therapy to identify factors associated with progression to high-grade dysplasia (HGD) or esophageal adenocarcinoma (EAC) in patients with LGD of the esophagus.

METHODS: We performed a retrospective analysis of data from 255 patients with a primary diagnosis of LGD (78% men; mean age, 63 ...

Also Ranks for: Patients Lgd |  hgd eac |  grade dysplasia |  interquartile range |  factors progression
KOL Index score: 12937

OBJECTIVES: Noninvasive biomarkers would be valuable for diagnosis and monitoring of eosinophilic esophagitis (EoE). The aim of this study was to determine the utility of a panel of serum biomarkers for the diagnosis and management of EoE.

METHODS: We conducted a prospective cohort study of consecutive adults undergoing outpatient esophagogastroduodenoscopy. Incident cases of EoE were diagnosed per consensus guidelines; controls had gastroesophageal reflux disease (GERD) or dysphagia and ...

Also Ranks for: Eosinophilic Esophagitis |  eoe cases |  serum biomarkers diagnosis |  controls baseline |  noninvasive biomarkers

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Nicholas James Shaheen:Expert Impact

Concepts for whichNicholas James Shaheenhas direct influence:Eosinophilic esophagitis,  Esophageal adenocarcinoma,  Barrett esophagus,  Radiofrequency ablation,  Barretts esophagus,  United states,  Eosinophilic esophagitis eoe,  Intestinal metaplasia.

Nicholas James Shaheen:KOL impact

Concepts related to the work of other authors for whichfor which Nicholas James Shaheen has influence:Eosinophilic esophagitis,  Acute pancreatitis,  Esophageal adenocarcinoma,  Barrett esophagus,  United states,  Colorectal cancer,  Reflux disease.



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Division of Gastroenterology and Hepatology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; | Division of Gastroenterology and Hepatology, University of North Carolina, Chapel Hill, North Carolina | Division of Gastroe