Prominent publications by Ola Arvid Selnes

KOL Index score: 14417

OBJECTIVE: To evaluate whether baseline levels of plasma and CSF HIV RNA, tumor necrosis factor alpha (TNFalpha), monocyte chemoattractant protein-1 (MCP-1), matrix metalloproteinase-2 (MMP-2), or macrophage colony stimulating factor (M-CSF) are predictors of incident HIV-associated dementia (HIVD) in a cohort with advanced HIV infection.

METHODS: A total of 203 nondemented subjects with CD4 lymphocyte counts less than 200/muL, or <300/microL but with cognitive impairment, underwent ...

Also Ranks for: Hiv Rna |  immune activation |  viral load |  cd4 lymphocyte |  baseline levels
KOL Index score: 12856

Recent evidence indicates that measures from cerebrospinal fluid, MRI scans and cognitive testing obtained from cognitively normal individuals can be used to predict likelihood of progression to mild cognitive impairment several years later, for groups of individuals. However, it remains unclear whether these measures are useful for predicting likelihood of progression for an individual. The increasing focus on early intervention in clinical trials for Alzheimer's disease emphasizes the ...

Also Ranks for: Mild Cognitive Impairment |  normal cognition |  5 years |  alzheimers disease |  sensitivity specificity
KOL Index score: 12682

BACKGROUND: Depression is commonly reported after coronary artery bypass grafting (CABG), and after cardiac surgery in general. Many earlier reports relied on non-standard assessments of depression, which may have overestimated its frequency. Cognitive decline has also been reported after CABG. We assessed the frequency of depression after CABG by a validated depression measure (Center for Epidemiological Study of Depression, CES-D), and examined the relation between depression and ...

Also Ranks for: Cognitive Decline |  depression cabg |  coronary artery |  patients surgery |  1 year
KOL Index score: 12228

BACKGROUND: Cognitive impairment after coronary artery bypass grafting (CABG) is well recognized, but previous investigations have been limited by lack of an appropriate control group. We compared changes in cognitive performance at 3 and 12 months after CABG with those in a control group of patients with comparable risk factors for coronary artery disease (CAD) who had not undergone surgery.

METHODS: Patients undergoing CABG (n = 140) and demographically similar nonsurgical control ...

Also Ranks for: Coronary Artery Disease |  artery bypass |  nonsurgical controls |  patients cabg |  3 months
KOL Index score: 12221

OBJECTIVE: To determine the long-term (preoperative to 5 years postoperative) and late (1-5 years postoperative) changes in cognitive test performance in patients after coronary artery bypass grafting.

SETTING: The departments of surgery and neurology at The Johns Hopkins University School of Medicine, Baltimore, Md.

PATIENTS: A group of 102 patients who completed preoperative and follow-up cognitive testing up to 5 years after coronary artery bypass grafting.


Also Ranks for: 5 Years |  coronary artery |  late decline |  bypass grafting |  cognitive domains
KOL Index score: 12200

IMPORTANCE: Clinical trials testing treatments for Alzheimer disease (AD) are increasingly focused on cognitively normal individuals in the preclinical phase of the disease. To optimize observing a treatment effect, such trials need to enroll cognitively normal individuals likely to show cognitive decline over the duration of the trial.

OBJECTIVE: To identify which group of cognitively normal individuals shows the greatest cognitive decline over time based on their cerebrospinal fluid ...

Also Ranks for: Alzheimer Disease |  tau stage |  cognitively normal individuals |  longitudinal cognitive |  baseline age
KOL Index score: 12177

BACKGROUND: Although controversial, failing to consider the gravitational effects of head elevation on cerebral perfusion is speculated to increase susceptibility to rare, but devastating, neurologic complications after shoulder surgery in the beach chair position (BCP). We hypothesized that patients in the BCP have diminished cerebral blood flow autoregulation than those who undergo surgery in the lateral decubitus position (LDP). A secondary aim was to examine whether there is a ...

Also Ranks for: Shoulder Surgery |  beach chair position |  cerebral autoregulation |  bcp patients |  arterial blood pressure
KOL Index score: 11540

BACKGROUND: In contrast to perioperative stroke, much less attention has been paid to those with evidence of diffuse brain encephalopathy, presenting as delirium, confusion, coma, and seizures in the immediate postoperative period.

OBJECTIVE: To determine the incidence, consequences, and predictive factors for encephalopathy and stroke following coronary artery bypass grafting.

METHODS: In a prospective evaluation of 2711 patients operated on between January 1, 1997, and December 31, ...

Also Ranks for: Encephalopathy Stroke |  coronary artery |  bypass grafting |  predictive factors |  outcomes surgery
KOL Index score: 10647

BACKGROUND: Coronary artery bypass grafting has been associated with both early and late postoperative cognitive decline, but interpretation of previous studies has been limited by lack of appropriate control groups. We compared changes in cognitive performance from baseline to 3 years in patients undergoing coronary artery bypass grafting with those of a control group of patients with known risk factors for coronary artery disease but without surgery.

METHODS: Patients undergoing ...

Also Ranks for: Coronary Artery |  cognitive outcomes |  bypass surgery |  3 years |  neuropsychological tests
KOL Index score: 10467

This study evaluated the utility of baseline and longitudinal magnetic resonance imaging (MRI) measures of medial temporal lobe brain regions collected when participants were cognitively normal and largely in middle age (mean age 57 years) to predict the time to onset of clinical symptoms associated with mild cognitive impairment (MCI). Furthermore, we examined whether the relationship between MRI measures and clinical symptom onset was modified by apolipoprotein E (ApoE) genotype and ...

Also Ranks for: Apoe Genotype |  symptom onset |  medial temporal |  entorhinal cortex |  lobe atrophy
KOL Index score: 10351

Human immunodeficiency virus (HIV)-associated cognitive impairment, a significant cause of morbidity, affects up to 30% of HIV-infected people. Its prevalence doubled as patients began to live longer after the introduction of highly active retroviral therapy. Women are now one of the fastest growing groups with acquired immunodeficiency syndrome (AIDS) in the United States and Puerto Rico, but relatively little is known about the prevalence and characteristics of cognitive dysfunction in ...

Also Ranks for: Cognitive Impairment |  hispanic women |  united states |  human immunodeficiency virus |  puerto rico
KOL Index score: 10125

Limited attention has been paid to the potential impact of gender and injection drug use (IDU) on mood, quality of life, and neuropsychological performance in human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS). Several studies that describe the natural history of HIV/AIDS in terms of mental health and neuropsychological ability have focused solely on men or have excluded injection drug users. Women and injection drug users are two groups for whom the incidence of ...

Also Ranks for: Depressive Symptoms |  injection drug |  hiv aids |  neuropsychological performance |  quality life

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Ola Arvid Selnes:Expert Impact

Concepts for whichOla Arvid Selneshas direct influence:Hiv dementia,  Hiv infection,  Coronary artery,  Artery bypass,  Cognitive impairment,  Cardiac surgery,  Cognitive decline,  Cognitive performance.

Ola Arvid Selnes:KOL impact

Concepts related to the work of other authors for whichfor which Ola Arvid Selnes has influence:Cardiac surgery,  Hiv infection,  Cognitive impairment,  Coronary artery,  Antiretroviral therapy,  Cardiopulmonary bypass,  Human immunodeficiency virus.



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Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. | Johns Hopkins School of Medicine, Baltimore, MD, USA | Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland | From