Direct Impact

Concepts for which they have direct influence:

indolent lymphoma
lymphocytic leukemia
phase trial
waldenstrom macroglobulinemia
dolastatin treating
cancer cells
drugs chemotherapy

Phase II Trial of Dolastin 10 in Indolent Lymphoma and Chronic Lymphocytic Leukemia. Dolastatin 10 in Treating Patients With Indolent Lymphoma, Waldenstrom's Macroglobulinemia, or Chronic Lymphocytic

Abstract

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die.PURPOSE: Phase II trial to study the effectiveness of dolastatin 10 in treating patients with indolent lymphoma, Waldenstrom's macroglobulinemia, or chronic lymphocytic leukemia. Detailed Description OBJECTIVES:Estimate the efficacy of dolastatin 10 in patients with indolent lymphoma, Waldenstrom's macroglobulinemia, or chronic lymphocytic leukemia.Evaluate the qualitative and quantitative toxicities of dolastatin 10 in this patient population.Investigate the mechanism of action of dolastatin 10 in regards to apoptosis and effects of microtubules.OUTLINE: This is an open-label, multicenter study. Patients are stratified by disease (chronic lymphocytic leukemia vs indolent lymphoma vs Waldenstrom's macroglobulinemia).All patients receive dolastatin 10 IV bolus every 3 weeks. Patients continue treatment until disease progression, unacceptable toxicity, or patient's withdrawal from the study.PROJECTED ACCRUAL: A maximum of 74 patients will be accrued for this study over 15 months.. RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die.PURPOSE: Phase II trial to study the effectiveness of dolastatin 10 in treating


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