Plantar Fibromatosis: An Immunohistochemical and Ultrastructural Study: Influence Statistics

Expert Impact

Concepts for which they have has direct influence: Plantar fibromatosis , Dupuytrens disease , Palmar fibromatosis , Dupuytren contracture , Foot diseases , Fibroma foot , Female fibroma .

Key People For Plantar Fibromatosis

Top KOLs in the world
#1
Keith L Wapner
achilles tendon hunter rod hallucis longus
#2
Paul J Hecht
achilles tendon peroneal splits plantar fibromatosis
#3
Thomas H Lee
hallux valgus intermetatarsal facet lower extremity
#4
Hans Roland Dürr
regional hyperthermia multiple myeloma bone metastases
#5
Hans Jürgen Refior
synovial microcirculation surgical treatment magnetic resonance imaging
#6
Andreas Lienemann
pelvic floor magnetic resonance intraabdominal adhesions

Plantar Fibromatosis: An Immunohistochemical and Ultrastructural Study

Abstract

. The analogies between plantar fibromatosis and Dupuytren's disease (palmar fibromatosis) are well known. The latter is clinically more frequent and has been the object of extensive immunohistochemical and ultrastructural studies, with a view to investigating its pathogenesis. By contrast, such data on plantar fibromatosis are quite scarce. A histochemical, immunohistochemical, and ultrastructural study was performed on nodule tissue from six patients who were subjected to total fasciectomy for plantar fibromatosis. The study of myofibroblasts revealed features suggestive of their fibroblastic origin and evidenced a cytoskeleton and an extracellular filamentous system that could enable myofibroblasts to generate and exert the intracellular forces that contribute to the contraction of the aponeurosis. These aspects are similar to those observed in Dupuytren's disease and seem to lend support to the theory that the two diseases are expressions of the same disorder.