Prognosis of Primary Mucosal Penile Melanoma: A Series of 19 Dutch Patients and 47 Patients from the Literature: Influence Statistics

Expert Impact

Concepts for which they have has direct influence: Penile melanoma , Primary mucosal , Cutaneous melanoma , Distal urethra , Fossa navicularis , Primary mucosal melanoma , Glans penis .

Key People For Penile Melanoma

Top KOLs in the world
#1
Curtis Alvin Pettaway
prostate cancer african ancestry lymph node
#2
Victor Gerardo Prieto
melanocytic lesions cutaneous melanoma sentinel lymph nodes
#3
Pheroze Tamboli
renal cell cytoreductive nephrectomy urinary tract
#4
RICARDO F Sánchez‐Ortiz
prostate cancer collagen injection puerto rican
#5
GREG HESTER
male urethra patients penile melanoma median followup
#6
SAMUEL F HUANG
total pelvic exenteration perineal pain prostate cancer patients

Prognosis of Primary Mucosal Penile Melanoma: A Series of 19 Dutch Patients and 47 Patients from the Literature

Abstract

. OBJECTIVES: To analyze the clinical features, prognostic factors, and survival of male patients with primary mucosal melanoma on the glans penis, meatus, fossa navicularis, and distal urethra. METHODS: We analyzed the clinical features, prognostic factors, and survival of 66 male patients with primary mucosal melanoma on the glans penis, meatus, fossa navicularis, and distal urethra diagnosed over the past 25 years. Data from our series of 19 patients were combined with those of 47 patients reported in the literature. RESULTS: The overall 2 and 5-year survival rates were 63% and 31%, respectively. All patients with nodal and/or distant metastases at presentation died within 2 years. Presence of ulceration, tumor depth of 3.5 mm or more, and tumor diameter greater than 15 mm had a significantly adverse effect on prognosis. CONCLUSIONS: The prognosis of primary mucosal penile melanoma is not worse than that for cutaneous melanoma with comparable tumor thickness. Treatment should be similar to that for cutaneous melanoma, with wide radical excision and sentinel node biopsy in clinically lymph node-negative patients.