Radiation Therapy for Neovascular Age-related Macular Degeneration: Influence Statistics

Expert Impact

Concepts for which they have has direct influence: Macular degeneration , Radiation therapy , Neovascular age , Visual acuity , Proton therapy , Agerelated macular degeneration , Anti vegf .

Key People For Macular Degeneration

Top KOLs in the world
#1
Ronald E Klein
diabetic retinopathy beaver dam atherosclerosis risk
#2
Paul A Mitchell
visual impairment diabetic retinopathy cataract surgery
#3
Barbara E K Klein
diabetic retinopathy beaver dam blood pressure
#4
Alan C Charles
retinitis pigmentosa fundus autofluorescence visual acuity
#5
Frederick L III Ferris
diabetic retinopathy visual acuity macular edema
#6
Neil M Bressler
visual acuity diabetic macular edema choroidal neovascularization

Radiation Therapy for Neovascular Age-related Macular Degeneration

Abstract

. In the enormity of the public health burden imposed by age-related macular degeneration (ARMD), much effort has been directed toward identifying effective and efficient treatments. Currently, anti-vascular endothelial growth factor (VEGF) injections have demonstrated considerably efficacy in treating neovascular ARMD, but patients require frequent treatment to fully benefit. Here, we review the rationale and evidence for radiation therapy of ARMD. The results of early photon external beam radiation therapy are included to provide a framework for the sequential discussion of evidence for the usage of stereotactic radiation therapy, proton therapy, and brachytherapy. The evidence suggests that these 3 modern modalities can provide a dose-dependent benefit in the treatment of ARMD. Most importantly, preliminary data suggest that all 3 can be used in conjunction with anti-VEGF therapeutics, thereby reducing the frequency of anti-VEGF injections required to maintain visual acuity.