SNARE complex in developmental psychiatry: neurotransmitter exocytosis and beyond: Influence Statistics

Expert Impact

Concepts for which they have has direct influence: Snare complex , Neurotransmitter exocytosis , Psychiatric disorders , Bipolar disorder , Snare proteins , Distinct roles , Genetic variants .

Key People For Snare Complex

Top KOLs in the world
#1
Reinhard Reinhard
synaptic vesicles membrane fusion snare proteins
#2
Thomas Christian Südhof
synaptic vesicles neurotransmitter release alternative splicing
#3
James Edward Rothman
membrane fusion golgi stack endoplasmic reticulum
#4
Richard H Scheller
membrane fusion synaptic vesicles snare proteins
#5
Thomas H Söllner
membrane fusion snare proteins golgi stack
#6
Dirk Fasshauer
snare proteins membrane fusion neurosecretory vesicles

SNARE complex in developmental psychiatry: neurotransmitter exocytosis and beyond

Abstract

. Multiple biological processes throughout development require intracellular vesicular trafficking, where the SNARE (soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptors) complex plays a major role. The core proteins forming the SNARE complex are SNAP-25 (synaptosomal-associated protein 25), VAMP (vesicle-associated membrane protein) and Syntaxins, besides its regulatory proteins, such as Synaptotagmin. Genes encoding these proteins (SNAP25, VAMP1, VAMP2, STX1A, SYT1 and SYT2) have been studied in relation to psychiatric disorders susceptibility. Here, we review physiological aspects of SNARE complex and genetic association results reported for attention deficit hyperactivity disorder, both in children and adults, autism spectrum disorders, major depressive disorder, bipolar disorder and schizophrenia. Moreover, we included findings from expression, pharmacogenetics and animal model studies regarding these clinical phenotypes. The overall scenario depicted here suggests that the SNARE complex may exert distinct roles throughout development, with age-specific effects of genetic variants in psychiatric disorders. Such perspective should be considered in future studies regarding SNARE complex genes.