Synthesis and antibacterial activity of C2-fluoro, C6-carbamate ketolides, and their C9-oximes: Influence Statistics

Expert Impact

Concepts for which they have has direct influence: Antibacterial activity , Haemophilus influenzae , Compounds series , Synthesis antibacterial activity , Activity relationship , Anti bacterial , Bacterial agents .

Key People For Antibacterial Activity

Top KOLs in the world
#1
Robert E W Hancock
pseudomonas aeruginosa outer membrane antimicrobial peptides
#2
MAHENDRA KUMAR Rai
silver nanoparticles essential oils medicinal plants
#3
William M M Kirby
intramuscular injections clinical pharmacology bacterial pneumonia
#4
M Turck
microbial enterobacteriaceae susceptibility testing standardized single
#5
J C Sherris
microbial enterobacteriaceae standardized single susceptibility testing
#6
A W Bauer
microbial enterobacteriaceae standardized single susceptibility testing

Synthesis and antibacterial activity of C2-fluoro, C6-carbamate ketolides, and their C9-oximes

Abstract

. Novel C6-carbamate ketolides with C2-fluorination and C9-oximation have been synthesized. The best compounds in this series displayed MIC values of 0.03-0.12 microg/mL against streptococci containing erm and mef resistance determinants and 2-4 microg/mL against Haemophilus influenzae. Several compounds also showed measurable activity against erm(B)-containing enterococci with MIC values of 2-8 microg/mL. In vivo activity was adversely affected by fluorination, possibly as a result of increased serum protein binding.