• Breast Cancer
    • Wei Wei Liu
    • Wei Wei Liu: Influence Statistics

      Wei Wei Liu

      Wei Wei Liu

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      School of Information Engineering, Hubei MinZu University, Enshi, Hubei, China | Hubei Engineering Research Center for Rural Drinking Water Security, Wuhan 430062, China | ...

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      Wei Wei Liu:Expert Impact

      Concepts for whichWei Wei Liuhas direct influence:Breast cancer.

      Wei Wei Liu:KOL impact

      Concepts related to the work of other authors for whichfor which Wei Wei Liu has influence:Thermal conductivity,Oxidative stress,Cancer cells,Cell death,Gene expression,Autophagic flux,Mental health.

      KOL Resume for Wei Wei Liu

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      Sample of concepts for which Wei Wei Liu is among the top experts in the world.
      Concept World rank
      decentralized federated learning #1
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      prognosis breast cancer #1
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      selective stacking #1
      compression area #1
      language teaching methodology #1
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      combination agvhd #1
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      chlamydia psittaci pneumonia #1
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      Prominent publications by Wei Wei Liu

      KOL-Index: 25620

      BACKGROUND: Cisplatin-based adjuvant chemotherapy is the standard of care for patients with resected stage II-IIIA non-small-cell lung cancer (NSCLC). RADIANT and SELECT trial data suggest patients with EGFR-mutant stage IB-IIIA resected NSCLC could benefit from adjuvant EGFR tyrosine kinase inhibitor treatment. We aimed to compare the efficacy of adjuvant gefitinib versus vinorelbine plus cisplatin in patients with completely resected EGFR-mutant stage II-IIIA (N1-N2) NSCLC.

      METHODS: We ...

      Known for Adjuvant Treatment | Patients Gefitinib | Vinorelbine Cisplatin | Mutant Nsclc | Tumor Carcinoma
      KOL-Index: 23721

      BACKGROUND: Measuring disease and injury burden in populations requires a composite metric that captures both premature mortality and the prevalence and severity of ill-health. The 1990 Global Burden of Disease study proposed disability-adjusted life years (DALYs) to measure disease burden. No comprehensive update of disease burden worldwide incorporating a systematic reassessment of disease and injury-specific epidemiology has been done since the 1990 study. We aimed to calculate ...

      Known for Global Burden | 291 Diseases | Systematic Analysis | Child Child | Disability Ylds
      KOL-Index: 20720

      BACKGROUND: Non-fatal health outcomes from diseases and injuries are a crucial consideration in the promotion and monitoring of individual and population health. The Global Burden of Disease (GBD) studies done in 1990 and 2000 have been the only studies to quantify non-fatal health outcomes across an exhaustive set of disorders at the global and regional level. Neither effort quantified uncertainty in prevalence or years lived with disability (YLDs).

      METHODS: Of the 291 diseases and ...

      Known for Systematic Analysis | Global Burden | Disability Ylds | Prevalence Years | Health Systems
      KOL-Index: 19735

      BACKGROUND Patients with advanced non-small cell lung cancer (NSCLC) treated with cisplatin, also termed cis-diamminedichloroplatinum (CDDP) or diamminedichloroplatinum (DDP), may develop chemoresistance. This study aimed to investigate the role of long non-coding RNA (lncRNA) X-inactive specific transcript (XIST) and multidrug resistance-1 (MDR1) in tumor tissue samples and the chemoresistant human NSCLC cell lines, H460/DDP and A549/DDP, and in a murine A549/DDP tumor xenograft. ...

      Known for Cisplatin Resistance | Cell Lung | Patients Nsclc | Lncrna Xist | Long Noncoding Rna
      KOL-Index: 19008

      BACKGROUND: Adjuvant chemotherapy after radical resection of stage IIIA non-small-cell lung cancer (NSCLC) has quite poor outcomes. We aimed to investigate whether adjuvant erlotinib therapy improves 2-year disease-free survival compared with chemotherapy in epidermal growth factor receptor (EGFR) mutation-positive stage IIIA NSCLC.

      METHODS: In this randomised, open-label, phase 2 trial, eligible patients aged 18-75 years who had undergone complete (R0) resection of histologically or ...

      Known for Adjuvant Therapy | Egfr Mutation | Stage Iiia | Cell Lung | Patients Nsclc
      KOL-Index: 16846

      Cells from individuals with the recessive cancer-prone disorder ataxia telangiectasia (A-T) are hypersensitive to ionizing radiation (I-R). ATM (mutated in A-T) is a protein kinase whose activity is stimulated by I-R. c-Abl, a nonreceptor tyrosine kinase, interacts with ATM and is activated by ATM following I-R. Rad51 is a homologue of bacterial RecA protein required for DNA recombination and repair. Here we demonstrate that there is an I-R-induced Rad51 tyrosine phosphorylation, and ...

      Known for Cabl Atm | Rad51 Rad52 | Proteins Abl | Genetic Saccharomyces | Dna Recombination
      KOL-Index: 16551

      BACKGROUND: Ending the global tobacco epidemic is a defining challenge in global health. Timely and comprehensive estimates of the prevalence of smoking tobacco use and attributable disease burden are needed to guide tobacco control efforts nationally and globally.

      METHODS: We estimated the prevalence of smoking tobacco use and attributable disease burden for 204 countries and territories, by age and sex, from 1990 to 2019 as part of the Global Burden of Diseases, Injuries, and Risk ...

      Known for Smoking Tobacco | Global Burden | 204 Countries | Systematic Analysis | Demographic Patterns
      KOL-Index: 16503

      Increasing evidence has suggested that paracrine mechanisms might be involved in the underlying mechanism of mesenchymal stem cells (MSCs) transplantation, and exosomes are an important component of this paracrine role. However, MSCs are usually exposed to normoxia (21% O2) in vitro but experience large differences in oxygen concentration in the body under hypoxia. Indeed, hypoxic precondition of MSCs can enhance their paracrine effects. The main purpose of this study was to determine ...

      Known for Fracture Healing | Stem Cell | Derived Exosomes | Mscs Hypoxia | Exosomal Mir126
      KOL-Index: 15882

      BACKGROUND & AIMS: Formin-like (FMNL)2 is up-regulated in colorectal tumors and has been associated with tumor progression, but little is known about regulatory mechanisms. We investigated whether microRNAs regulate levels of FMNL2 in colorectal cancer (CRC) cells.

      METHODS: We used real-time polymerase chain reaction and immunoblot analyses to measure levels of miR-137, high-mobility group AT-hook (HMGA)1, and FMNL2 in CRC cells and tissue samples from patients (n = 50). We used ...

      Known for Crc Cells | Cell Invasion | Directly Targeting | Mir137 Expression | Matrix Metalloproteinase
      KOL-Index: 15319

      We present for the first time that histone deacetylase 6 (HDAC6) regulates EGFR degradation and trafficking along microtubules in Pkd1 mutant renal epithelial cells. HDAC6, the microtubule-associated α-tubulin deacetylase, demonstrates increased expression and activity in Pkd1 mutant mouse embryonic kidney cells. Targeting HDAC6 with a general HDAC inhibitor, trichostatin (TSA), or a specific HDAC6 inhibitor, tubacin, increased the acetylation of α-tubulin and downregulated the ...

      Known for Epithelial Cells | Histone Deacetylase Hdac6 | Growth Factor | Egf Egfr | Α Tubulin
      KOL-Index: 14861

      OBJECTIVE: To explore the application of joint detection of serum AFP, CA19-9, CA125 and CEA in identification and diagnosis of cholangiocarcinoma (CC).

      MATERIALS AND METHODS: The levels of serum AFP, CA19-9, CA125 and CEA of both 30 patients with CC and 30 patients with hepatocellular carcinoma (HCC) were assessed. Receiver operating characteristic (ROC) curves were used to evaluate the diagnostic effects of single and joint detection of those 4 kinds of tumor markers for CC.

      RESULTS: ...

      Known for Roc Curve | Serum Afp Ca125 | Afp Ca19 | Single Detection | Diagnosis Cholangiocarcinoma
      KOL-Index: 14810

      BACKGROUND: The obesity-hypertension pathogenesis is complex. From the phenotype to molecular mechanism, there is a long way to clarify the mechanism. To explore the association between obesity and hypertension, we correlate the phenotypes such as the waist circumference (WC), body mass index (BMI), systolic blood pressure (SB), and diastolic blood pressure (DB) with the clinical laboratory data between four specific Chinese adult physical examination groups (newly diagnosed untreated ...

      Known for Obesity Hypertension | Waist Circumference | Blood Pressure | Bmi Wc | Clinical Laboratory Data

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      School of Information Engineering, Hubei MinZu University, Enshi, Hubei, China | Hubei Engineering Research Center for Rural Drinking Water Security, Wuhan 430062, China | From the, Department of Nuclear Medicine, The Affiliated Hospital of Southwest

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