Prominent publications by John F Holbrook

KOL Index score: 3685

BACKGROUND AND PURPOSE: Intracranial pressure is estimated invasively by using lumbar puncture with CSF opening pressure measurement. This study evaluated displacement encoding with stimulated echoes (DENSE), an MR imaging technique highly sensitive to brain motion, as a noninvasive means of assessing intracranial pressure status.

MATERIALS AND METHODS: Nine patients with suspected elevated intracranial pressure and 9 healthy control subjects were included in this prospective study. ...

Also Ranks for: Intracranial Pressure |  displacement encoding |  stimulated echoes |  brain motion |  imaging findings
KOL Index score: 3404

BACKGROUND: Optic nerve sheath tortuosity is a previously reported, but incompletely characterized, finding in idiopathic intracranial hypertension (IIH). We hypothesized that optic nerve angle (ONA), as a quantitative measure of tortuosity, would change dynamically with cerebrospinal fluid (CSF) pressure status of patients with IIH immediately before and after lumbar puncture (LP).

METHODS: Consecutive patients with suspected IIH referred for MRI and diagnostic LP were prospectively ...

Also Ranks for: Patients Iih |  magnetic resonance |  nerve angle |  cerebrospinal fluid |  lumbar puncture
KOL Index score: 3182

Intracranial pressure (ICP) is the pressure inside the bony calvarium and can be affected by a variety of processes, such as intracranial masses and edema, obstruction or leakage of cerebrospinal fluid, and obstruction of venous outflow. This review focuses on the imaging of 2 important but less well understood ICP disorders: idiopathic intracranial hypertension and spontaneous intracranial hypotension. Both of these ICP disorders have salient imaging findings that are important to ...

Also Ranks for: Intracranial Pressure |  cerebrospinal fluid |  pseudotumor cerebri |  imaging findings |  neurological disorders
KOL Index score: 2719

Subarachnoid-pleural fistulas (SPFs) are rare clinical entities that occur after severe thoracic trauma or iatrogenic injury during anterolateral approaches to the spine. Treatment of these fistulas often entails open repair of the dural defect. The authors present the case of an SPF in a 2-year-old female after a penetrating injury to the chest. The diagnosis of an SPF was suspected given the high chest tube output and was confirmed with a positive β2-transferrin test of the chest tube ...

Also Ranks for: Fibrin Glue |  pleural fistula |  surgical repair |  dura mater |  tissue adhesive
KOL Index score: 1808

Lumbar stenosis is a common radiographic finding that sometimes can be symptomatic. It usually results from a degenerative process of hypertrophic facets, ligamentum flavum hypertrophy, and disc involvement. A prominence of fat in the epidural space, epidural lipomatosis, can also be a contributing factor. This case report presents a 55-year-old man with radiographic improvement of epidural lipomatosis and stenosis from dietary weight loss. Given the rising obesity epidemic, ...

Also Ranks for: Epidural Lipomatosis |  spinal stenosis |  weight loss
KOL Index score: 1374

PURPOSE: To determine whether orbital findings on routine brain MRI can be used to differentiate patients with intracranial hypotension from controls.

METHODS: The authors evaluated axial T2-weighted images for the amount of optic nerve sheath CSF and 3D-T1-weighted images for optic nerve angle of sixteen patients with intracranial hypotension and 60 controls.

RESULTS: Patients with intracranial hypotension demonstrated significantly decreased CSF in the optic nerve sheath. Optic nerve ...

Also Ranks for: Optic Nerve |  humans intracranial |  compared controls
KOL Index score: 722

BACKGROUND: The intervertebral disk is the largest avascular structure in the body. It relies on passive diffusion from arteries at the periphery of the disk for nutrition. Previous studies have suggested a correlation between vascular disease and lumbar degenerative disk disease (DDD), but the association with facet arthritis and stenosis has not been evaluated.

OBJECTIVE: To evaluate the degree of lumbar artery stenosis, aortic atherosclerosis on computed tomography angiography, and ...

Also Ranks for: Computed Tomography Angiography |  spinal canal

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John F Holbrook:Expert Impact

Concepts for whichJohn F Holbrookhas direct influence:Intracranial pressure,  Intracranial hypotension,  Intracranial pressure status,  Epidural lipomatosis,  Fibrin glue,  Spinal stenosis,  Stimulated echoes,  Displacement encoding.

John F Holbrook:KOL impact

Concepts related to the work of other authors for whichfor which John F Holbrook has influence:Intracranial pressure,  Fibrin glue,  Sensory block level,  Incidental durotomy,  Optic nerve,  Locomotive syndrome,  Anatomical dimensions.



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Department of Radiology and Imaging Sciences (RH, DQ, JO, and AMS), Emory University School of Medicine, Atlanta, Georgia; Northside Radiology Associates (JH), Atlanta, Georgia; and Department of Ophthalmology (NJN, VB, BBB), Emory University School