Prominent publications by Margaret M O'Malley

KOL Index score: 15493

BACKGROUND: Juvenile polyposis syndrome is a dominant GI polyposis syndrome defined by ≥ 5 GI juvenile polyps or ≥ 1 juvenile polyps with a family history of juvenile polyposis. Mutations in BMPR1A or SMAD4 are found in 50% of individuals. Hereditary hemorrhagic telangiectasia is a dominant disorder characterized by epistaxis, visceral arteriovenous malformations, and telangiectasias. Hereditary hemorrhagic telangiectasia is diagnosed when ≥ 3 criteria including clinical manifestations ...

Also Ranks for: Juvenile Polyposis |  hereditary hemorrhagic |  genetic testing |  protein telangiectasia |  smad4 mutation
KOL Index score: 11630

Hereditary hemorrhagic telangiectasia (HHT) is characterized by abnormal vascular structures that may present as epistaxis, telangiectasias, and/or arteriovenous malformations. The genes associated with HHT (ACVRL1, ENG, and SMAD4) are members of the TGFβ pathway. Other syndromes associated with abnormalities in TGFβ signaling include Marfan syndrome, Loeys-Dietz syndrome and related disorders. These disorders have aortic disease as a prominent finding. While there are case reports of ...

Also Ranks for: Hemorrhagic Telangiectasia |  patients smad4 |  acvrl1 eng |  juvenile polyposis |  aortic disease
KOL Index score: 11328

OBJECTIVE: Clarify the incidence of thyroid cancer in patients with Familial adenomatous polyposis (FAP) in a prospective study of thyroid neck US screening.

BACKGROUND: FAP is a hereditary disease predisposing to cancer in multiple organs, including the thyroid. However, routine thyroid screening for FAP patients is not generally practiced in the United States. Here, we report the initial results of a prospective thyroid cancer screening program in patients with FAP.

METHODS: At the ...

Also Ranks for: Thyroid Cancer |  familial adenomatous polyposis |  patients fap |  coli adolescent |  nodule ultrasonography
KOL Index score: 9456

BACKGROUND AND AIMS: The greatest known risk factor for duodenal cancer in familial adenomatous polyposis (FAP) is Spigelman stage (SS) IV duodenal polyposis. Endoscopic surveillance is recommended in FAP patients with SS 0 to IV, and prophylactic duodenectomy should be considered in SS IV. Cancer occurs in patients without SS IV polyposis. We assessed the relationship of SS and other factors with duodenal cancer in FAP.

METHODS: We performed a case-control study on 18 FAP patients with ...

Also Ranks for: Duodenal Cancer |  familial adenomatous polyposis |  spigelman stage |  fap patients |  endoscopic surveillance
KOL Index score: 9231

BACKGROUND: Germline mutations in SMAD4 and BMPR1A disrupt the transforming growth factor β signal transduction pathway, and are associated with juvenile polyposis syndrome. The effect of genotype on the pattern of disease in this syndrome is unknown. This study evaluated the differential impact of SMAD4 and BMPR1A gene mutations on cancer risk and oncological phenotype in patients with juvenile polyposis syndrome.

METHODS: Patients with juvenile polyposis syndrome and germline SMAD4 or ...

Also Ranks for: Juvenile Polyposis Syndrome |  cancer risk |  smad4 mutation |  intestinal polyposis |  type child
KOL Index score: 8117

BACKGROUND: Hyperplastic polyposis syndrome is a rare syndrome of colorectal cancer predisposition. Patterns of inheritance of hyperplastic polyposis syndrome are not obvious and the clinical definition is relatively arbitrary. We hypothesize that there are multiple phenotypes included in what is currently called hyperplastic polyposis syndrome. We performed this review of a large series of patients who presented with multiple serrated polyps to look for clinical patterns that may ...

Also Ranks for: Hyperplastic Polyposis Syndrome |  cancer risk |  colorectal polyps |  aged neoplasms |  10 mm
KOL Index score: 8042

OBJECTIVE: The primary aim of this study was to determine the prevalence of occult gynecologic malignancy at the time of risk reducing surgery in patients with Lynch Syndrome. A secondary aim was to determine the prevalence of occult gynecologic malignancy at the time of surgery for non-prophylactic indications in patients with Lynch Syndrome.

METHODS: A retrospective review of an Inherited Colorectal Cancer Registry found 76 patients with Lynch syndrome (defined by a germline mutation ...

Also Ranks for: Lynch Syndrome |  prophylactic surgery |  risk reducing |  disease genital neoplasms |  occult malignancy
KOL Index score: 7863

BACKGROUND AND AIMS: Gastric cancer (GC) is a newly described cancer risk in Western patients with familial adenomatous polyposis (FAP). Little is known about clinical, endoscopic, and pathologic features associated with FAP-related GC. We compared these features in FAP patients with and without GC.

METHODS: FAP patients were identified through the David G. Jagelman Inherited Colorectal Cancer Registries Cologene database. FAP patients with GC and randomly selected FAP patients without ...

Also Ranks for: Gastric Cancer |  fap patients |  adenomatous polyposis |  endoscopic features |  gc cases
KOL Index score: 6825

BACKGROUND: Desmoid disease can be a serious, life-threatening complication of familial adenomatous polyposis. The ability to predict patients at increased desmoid risk is important, but a convincing genotype-phenotype correlation for desmoid formation has not yet been described.

PURPOSE: The aim of this study is to assess the relationship between desmoid disease and genotype in patients with familial adenomatous polyposis.

DESIGN: This is a cohort study.

PATIENTS: All patients with ...

Also Ranks for: Familial Adenomatous Polyposis |  patients desmoid |  apc mutation |  fibromatosis aggressive |  coli adult
KOL Index score: 6712

The highest cancer risks in familial adenomatous polyposis (FAP) include colorectal, duodenal, and thyroid for which surveillance is recommended. Nearly all patients with FAP have gastric fundic gland polyposis (FGP), but gastric cancers are rarely reported with a similar incidence as the general population. We describe a recent, sudden increase in the incidence of gastric cancer in FAP. Seven of the ten cases were diagnosed in the last 20 months. Comparing our population to the SEER ...

Also Ranks for: Gastric Cancer |  patients fap |  familial adenomatous polyposis |  stomach neoplasms |  coli adult
KOL Index score: 5375

BACKGROUND AND AIMS: Proctocolectomy prevents colorectal cancer in familial adenomatous polyposis (FAP). Colorectal polyp progression is one of the indications for surgery. No data exist regarding the natural history of colorectal polyposis in young patients with FAP. This study examined the rate of polyposis progression and factors associated with it.

METHODS: Patients with FAP <30 years old who had undergone ≥2 colonoscopies since 2000 were identified. Rate of polyposis progression was ...

Also Ranks for: Young Patients |  adenomatous polyposis |  colorectal cancer |  polyp progression |  median rate
KOL Index score: 5134

BACKGROUND: Elective proctocolectomy has been recommended for patients at high risk of desmoids based on the possibility that cancer in a retained rectum may be unresectable because of desmoid disease. There are no data to support the reality of this concern.

OBJECTIVE: The aim of this study was to see how often proctectomy was prevented by desmoids.

DESIGN: This retrospective, descriptive, database study was augmented by chart review.

SETTING: This study was conducted at a hereditary ...

Also Ranks for: Ileorectal Anastomosis |  familial adenomatous polyposis |  desmoid tumors |  pouch anal |  aggressive humans
KOL Index score: 5013

BACKGROUND: Familial adenomatous polyposis (FAP) is a hereditary colon cancer syndrome that involves multiple extracolonic organs, including the thyroid. Several studies have estimated the rate of thyroid cancer in FAP to occur at five times the rate of the general population, but no current consensus defines screening for thyroid cancer in this cohort. This study seeks to define the features of benign and malignant thyroid disease in FAP patients, to compare thyroid cancer cases found ...

Also Ranks for: Adenomatous Polyposis |  fap patients |  thyroid cancer |  nodule ultrasonography |  fine needle
KOL Index score: 4753

BACKGROUND & AIMS: Ampullary and duodenal cancer are the leading causes of death in patients with familial adenomatous polyposis (FAP) after colectomy has been performed. Risk of duodenal cancer is determined based on Spigelman stage (SS) of duodenal polyposis. Guidelines recommend endoscopic surveillance of the duodenum and visualization of the papilla to stage duodenal polyposis. There is no consensus on whether biopsies should be routinely collected from duodenal papilla and findings ...

Also Ranks for: Familial Adenomatous Polyposis |  patients fap |  endoscopic surveillance |  spigelman stage |  duodenal neoplasms

Key People For Familial Adenomatous Polyposis

Top KOLs in the world
Robin * * ********
familial adenomatous polyposis anal fistula capsule endoscopy
Stanley * *********
colorectal cancer familial adenomatous polyposis microsatellite instability
Francis * **********
colorectal cancer familial adenomatous polyposis collagenous colitis
Steffen *****
familial adenomatous polyposis rectal cancer vitro tetraploidy
Randall * ****
colorectal cancer genetic testing lynch syndrome
Heikki ****** ********
colorectal cancer ulcerative colitis lynch syndrome

Margaret M O'Malley:Expert Impact

Concepts for whichMargaret M O'Malleyhas direct influence:Familial adenomatous polyposis,  Lynch syndrome,  Fap patients,  Duodenal cancer,  Juvenile polyposis,  Patients fap,  Adenomatous polyposis,  Juvenile polyposis syndrome.

Margaret M O'Malley:KOL impact

Concepts related to the work of other authors for whichfor which Margaret M O'Malley has influence:Familial adenomatous polyposis,  Colorectal cancer,  Serrated polyps,  Lynch syndrome,  Patients fap,  Desmoid tumors,  Genetic testing.



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Department of Colorectal Surgery, Cleveland Clinic, Cleveland, OH 44195, United States | Sanford R. Weiss, M.D. Center for Hereditary Colorectal Neoplasia, Digestive Disease and Surgical Institute, Cleveland Clinic, Cleveland, OH | Colorectal Surgery