Margaret M O'Malley: Influence Statistics

Margaret M O'Malley

Margaret M O'Malley

Department of Colorectal Surgery, Cleveland Clinic, Cleveland, OH 44195, United States | Sanford R. Weiss, M.D. Center for Hereditary Colorectal Neoplasia, Digestive Disease ...

Margaret M O'Malley: Expert Impact

Concepts for which Margaret M O'Malley has direct influence: Familial adenomatous polyposis , Lynch syndrome , Fap patients , Duodenal cancer , Juvenile polyposis , Patients fap , Adenomatous polyposis .

Margaret M O'Malley: KOL impact

Concepts related to the work of other authors for which for which Margaret M O'Malley has influence: Familial adenomatous polyposis , Colorectal cancer , Serrated polyps , Lynch syndrome , Patients fap , Desmoid tumors , Genetic testing .

KOL Resume for Margaret M O'Malley

Year
2022

Department of Colorectal Surgery, Cleveland Clinic, Cleveland, OH 44195, United States

2021

Sanford R. Weiss, M.D. Center for Hereditary Colorectal Neoplasia, Digestive Disease and Surgical Institute, Cleveland Clinic, Cleveland, OH

Colorectal Surgery

2020

Sanford R. Weiss MD Center for Hereditary Colorectal Neoplasia, Cleveland Clinic, Lakewood, Ohio.

2019

Sanford R. Weiss MD Center for Hereditary Colorectal Neoplasia, Cleveland Clinic, Cleveland, Ohio, USA;

Department of Colorectal Surgery, Cleveland Clinic, Ohio.

2018

Sanford R. Weiss, MD, Center for Hereditary Colorectal Neoplasia, Cleveland Clinic, Cleveland, Ohio, USA.

Department of Colorectal Surgery, Cleveland Clinic, Cleveland, OH, USA

2017

Sandford R. Weiss MD, Center for Hereditary Colorectal Cancer, Department of Colorectal Surgery, Cleveland Clinic Foundation, Cleveland, Ohio, USA

2016

Sanford R Weiss Center for Hereditary Colorectal Cancer Neoplasia and Digestive Disease Institute, Cleveland Clinic, Cleveland, OH 44195, USA

2015

Cleveland Clinic Digestive Disease Institute Cleveland Ohio

2014

Sanford R Weiss, MD, Center for Hereditary Colorectal Neoplasia, Cleveland Clinic Foundation, Cleveland, Ohio, Digestive Disease Institute, Cleveland Clinic Foundation, Cleveland, Ohio

2013

Cleveland Clinic, Cleveland, OH, USA

Sanford R. Weiss, MD, Center for Hereditary Colorectal Neoplasia

2012

Sanford R. Weiss MD Center for Hereditary Colorectal Neoplasia in the Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio

2011

Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio, Sanford R. Weiss, MD Center for Hereditary Colorectal Neoplasia, Digestive Disease Institute, Cleveland Clinic, Cleveland, Ohio

The Sanford R. Weiss, M.D, Center for Hereditary Colorectal Neoplasia, Digestive Diseases Institute, Desk A30, 9500 Euclid Ave., Cleveland Clinic, Cleveland, OH 44195, USA

2010

Sanford R. Weiss, M.D. Center for Hereditary Colorectal Neoplasia, Department of Colorectal Surgery, Cleveland Clinic, Cleveland, Ohio 44195, USA

Prominent publications by Margaret M O'Malley

KOL-Index: 15493 . BACKGROUND: Juvenile polyposis syndrome is a dominant GI polyposis syndrome defined by ≥ 5 GI juvenile polyps or ≥ 1 juvenile polyps with a family history of juvenile polyposis. Mutations in BMPR1A or SMAD4 are found in 50% of individuals. Hereditary hemorrhagic telangiectasia is a dominant disorder characterized by epistaxis, visceral arteriovenous malformations, and telangiectasias. ...
Known for Juvenile Polyposis | Hereditary Hemorrhagic | Genetic Testing | Protein Telangiectasia
KOL-Index: 11630 . Hereditary hemorrhagic telangiectasia (HHT) is characterized by abnormal vascular structures that may present as epistaxis, telangiectasias, and/or arteriovenous malformations. The genes associated with HHT (ACVRL1, ENG, and SMAD4) are members of the TGFβ pathway. Other syndromes associated with abnormalities in TGFβ signaling include Marfan syndrome, Loeys-Dietz syndrome and related ...
Known for Hemorrhagic Telangiectasia | Patients Smad4 | Acvrl1 Eng | Juvenile Polyposis
KOL-Index: 11328 . OBJECTIVE: Clarify the incidence of thyroid cancer in patients with Familial adenomatous polyposis (FAP) in a prospective study of thyroid neck US screening. BACKGROUND: FAP is a hereditary disease predisposing to cancer in multiple organs, including the thyroid. However, routine thyroid screening for FAP patients is not generally practiced in the United States. Here, we report the initial ...
Known for Thyroid Cancer | Familial Adenomatous Polyposis | Patients Fap | Coli Adolescent
KOL-Index: 9456 . BACKGROUND AND AIMS: The greatest known risk factor for duodenal cancer in familial adenomatous polyposis (FAP) is Spigelman stage (SS) IV duodenal polyposis. Endoscopic surveillance is recommended in FAP patients with SS 0 to IV, and prophylactic duodenectomy should be considered in SS IV. Cancer occurs in patients without SS IV polyposis. We assessed the relationship of SS and other ...
Known for Duodenal Cancer | Familial Adenomatous Polyposis | Spigelman Stage | Fap Patients
KOL-Index: 9231 . BACKGROUND: Germline mutations in SMAD4 and BMPR1A disrupt the transforming growth factor β signal transduction pathway, and are associated with juvenile polyposis syndrome. The effect of genotype on the pattern of disease in this syndrome is unknown. This study evaluated the differential impact of SMAD4 and BMPR1A gene mutations on cancer risk and oncological phenotype in patients with ...
Known for Juvenile Polyposis Syndrome | Cancer Risk | Smad4 Mutation | Intestinal Polyposis
KOL-Index: 8117 . BACKGROUND: Hyperplastic polyposis syndrome is a rare syndrome of colorectal cancer predisposition. Patterns of inheritance of hyperplastic polyposis syndrome are not obvious and the clinical definition is relatively arbitrary. We hypothesize that there are multiple phenotypes included in what is currently called hyperplastic polyposis syndrome. We performed this review of a large series ...
Known for Hyperplastic Polyposis Syndrome | Cancer Risk | Colorectal Polyps | Aged Neoplasms
KOL-Index: 8042 . OBJECTIVE: The primary aim of this study was to determine the prevalence of occult gynecologic malignancy at the time of risk reducing surgery in patients with Lynch Syndrome. A secondary aim was to determine the prevalence of occult gynecologic malignancy at the time of surgery for non-prophylactic indications in patients with Lynch Syndrome. METHODS: A retrospective review of an ...
Known for Lynch Syndrome | Prophylactic Surgery | Risk Reducing | Disease Genital Neoplasms
KOL-Index: 7863 . BACKGROUND AND AIMS: Gastric cancer (GC) is a newly described cancer risk in Western patients with familial adenomatous polyposis (FAP). Little is known about clinical, endoscopic, and pathologic features associated with FAP-related GC. We compared these features in FAP patients with and without GC. METHODS: FAP patients were identified through the David G. Jagelman Inherited Colorectal ...
Known for Gastric Cancer | Fap Patients | Adenomatous Polyposis | Endoscopic Features
KOL-Index: 6825 . BACKGROUND: Desmoid disease can be a serious, life-threatening complication of familial adenomatous polyposis. The ability to predict patients at increased desmoid risk is important, but a convincing genotype-phenotype correlation for desmoid formation has not yet been described. PURPOSE: The aim of this study is to assess the relationship between desmoid disease and genotype in patients ...
Known for Familial Adenomatous Polyposis | Patients Desmoid | Apc Mutation | Fibromatosis Aggressive
KOL-Index: 6712 . The highest cancer risks in familial adenomatous polyposis (FAP) include colorectal, duodenal, and thyroid for which surveillance is recommended. Nearly all patients with FAP have gastric fundic gland polyposis (FGP), but gastric cancers are rarely reported with a similar incidence as the general population. We describe a recent, sudden increase in the incidence of gastric cancer in FAP. ...
Known for Gastric Cancer | Patients Fap | Familial Adenomatous Polyposis | Stomach Neoplasms
KOL-Index: 5375 . BACKGROUND AND AIMS: Proctocolectomy prevents colorectal cancer in familial adenomatous polyposis (FAP). Colorectal polyp progression is one of the indications for surgery. No data exist regarding the natural history of colorectal polyposis in young patients with FAP. This study examined the rate of polyposis progression and factors associated with it. METHODS: Patients with FAP <30 years ...
Known for Young Patients | Adenomatous Polyposis | Colorectal Cancer | Polyp Progression
KOL-Index: 5134 . BACKGROUND: Elective proctocolectomy has been recommended for patients at high risk of desmoids based on the possibility that cancer in a retained rectum may be unresectable because of desmoid disease. There are no data to support the reality of this concern. OBJECTIVE: The aim of this study was to see how often proctectomy was prevented by desmoids. DESIGN: This retrospective, ...
Known for Ileorectal Anastomosis | Familial Adenomatous Polyposis | Desmoid Tumors | Pouch Anal
KOL-Index: 5013 . BACKGROUND: Familial adenomatous polyposis (FAP) is a hereditary colon cancer syndrome that involves multiple extracolonic organs, including the thyroid. Several studies have estimated the rate of thyroid cancer in FAP to occur at five times the rate of the general population, but no current consensus defines screening for thyroid cancer in this cohort. This study seeks to define the ...
Known for Adenomatous Polyposis | Fap Patients | Thyroid Cancer | Nodule Ultrasonography
KOL-Index: 4753 . BACKGROUND & AIMS: Ampullary and duodenal cancer are the leading causes of death in patients with familial adenomatous polyposis (FAP) after colectomy has been performed. Risk of duodenal cancer is determined based on Spigelman stage (SS) of duodenal polyposis. Guidelines recommend endoscopic surveillance of the duodenum and visualization of the papilla to stage duodenal polyposis. There ...
Known for Familial Adenomatous Polyposis | Patients Fap | Endoscopic Surveillance | Spigelman Stage

Key People For Familial Adenomatous Polyposis

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Randall W Burt
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Department of Colorectal Surgery, Cleveland Clinic, Cleveland, OH 44195, United States | Sanford R. Weiss, M.D. Center for Hereditary Colorectal Neoplasia, Digestive Disease and Surgical Institute, Cleveland Clinic, Cleveland, OH | Colorectal Surgery