Static Encephalopathy

What is Static Encephalopathy?

Static encephalopathy could be defined as a type of chronic brain disorders that are non-progressive in nature.

In other words, it is a type of brain dysfunctioning that is relatively constant and does not change over a period of time.

Static Encephalopathy significantly affects the motor functions and mechanisms that impact postures. Mental alterations caused due to static encephalopathy might result in a number of issues related to cognitive development. Static encephalopathy could be prevented by early treatment with focus on the primary causes that triggered the condition.

Static Encephalopathy Symptoms

The following are the symptoms of static encephalopathy:

1. Loss of memory and deterred consciousness.

2. Speech impairment and change in personality.

3. Depression, anxiety and decline in activity.

4. Apart from the cognitive symptoms, other symptoms that might be caused due to a more complex encephalopathy include seizures, abnormal breathing, coma and involuntary movements.

Encephalopathy: Key Players in Social Media

The most prominent accounts for the topic of encephalopathy are: NFLCFacts (active voice for retired NFL players), PharmaFactz, Elliot Tapper and Mark Oldham.

Types of encephalopathy

There are a number of causes which results in the development of static encephalopathy. The causes can range from environmental to genetics [1], and depending on the type of factor that triggered the condition, the types of static encephalopathy can be classified inas follows:

Metabolic Encephalopathy

Metabolic encephalopathy is a change in brain consciousness as a result of diffusion or global dysfunction of the brain caused due to compromised cerebral metabolism. In other words, a broad category of encephalopathy that covers the effect of changes in the metabolic activities on the brain functions is known as metabolic encephalopathy.

Discrepancies in the levels of vitamins, water, electrolytes and other chemicals in the body which might be a result of disordered metabolic processes could have adverse effects on the functioning of the brain. Continuous supply of oxygen, glucose and other nutrients to neurons through circulation plays a significant role in the metabolic functions of the brain and therefore an imbalance in their concentration could affect the brain activity thereby causing encephalopathy.

Acute Metabolic Encephalopathy

Acute metabolic encephalopathy is a type of metabolic encephalopathy as mentioned above that develops acutely and causes drowsiness with agitation that alters arousal when a metabolic disturbance occurs. Acute metabolic abnormalities in the blood sugar levels, vitamin levels, unwanted concentration of liver and kidney wastes, thyroid issues could also have an indirect impact on the process of brain functioning. However, the occurrence of acute metabolic encephalopathy is dependent on a number of factors that are responsible for changing blood flow, failure of the metabolism process related to energy and depolarization at cell levels [2].

Acute metabolic encephalopathies have shown a reversible potential given the underlying metabolic disorder is managed. However, if the abnormalities caused due to acute metabolic encephalopathies are not treated within a certain period of time then it may cause secondary damage to the brain structure that may in turn result in chronic encephalopathies.

Toxic Encephalopathy

Toxic encephalopathy is a type of encephalopathy triggered by brain function damage due to exposure to toxic materials. Generally, there is a significant relationship between the type of toxic exposure and the onset of symptoms and therefore the symptoms are immediately visible after acute exposure whereas a little delay in onset is observed when there is a chronic exposure of toxic substances.

Neurotoxins like organic solvents, heavy metals and other chemicals have the potential to cause a decline in the brain reserves thereby creating more vulnerability in the brain cells with respect to aging.

Acute toxic encephalopathy may occur due to exposure to organic solvents that have the potential to penetrate into the cell membrane whereas exposure to certain gasses like cyanide, carbon monoxide, anesthetics and hydrogen sulfide can diffuse and affect functions of the brain, whereas chronic toxic encephalopathy is caused through long-term exposure of toxins that causes continuous diffusion injury to the brain.

Epileptic Encephalopathy

Epileptic Encephalopathy is marked by a A decline in the neurological function caused due to epileptic activities like severe seizures or interictal activity at sub continuous paroxysmal.

Seizures are caused due to a sudden electrical activity in the brain and can have a significant impact on the motility, behavior and consciousness of an individual. The prevalence of epileptic encephalopathy is mostly observed during the early childhood years and is dependent on the functional and structural growth of the brain. Since seizures do not follow a particular pattern and high level of randomness, the recognition as well as management of epileptic encephalopathy becomes quite significant. Cerebral malformation could also be an underlying reason for seizures that can in turn onset epileptic encephalopathy that could help in treating seizures through neurosurgery in certain cases.

Static Encephalopathy Diagnosis and Treatment

A general brain test and the observation of symptoms by a medical expert could be used to diagnose static encephalopathy. Imaging techniques like an MRI or CT scans could be used to find the location and magnitude of the brain issues. Electroencephalography (EEG) test could also be used to diagnose encephalopathy as it is responsible for measuring the brain’s electrical activity. Spinal fluids, blood or urine tests could also be used for diagnosis.

Medications to stop seizures could be used to treat epileptic encephalopathy whereas dialysis could be used to treat metabolic encephalopathy. Improving the quality of life through consuming nutritional supplements and exercising on a regular basis could also be used to manage metabolic and toxic encephalopathy.


Facet Arthropathy - References

  1. ^ Noboru N Mizushima, et. al. (2013). De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood. Retrieved 29 Oct 2022.
  2. ^ Jain P., et. al. (2013). Diagnosis and Management of Epileptic Encephalopathies in Children. Epilepsy Research and Treatment, 501981. https://doi.org/10.1155%2F2013%2F501981. Retrieved 29 Oct 2022.
  3. ^ Surtis R. and Leonard J. (1989). Acute metabolic encephalopathy: a review of causes, mechanisms and treatment. Journal of Inherited Metabolic Disease, 1:42-54. https://doi.org/10.1007/bf01799285 . Retrieved 30 Oct 2022.

Recent articles about Static Encephalopathy

Mri, Mr Spectroscopy, And Diffusion Tensor Imaging Findings In Patient With...

[ PUBLICATION ] . Static encephalopathy of childhood with neurodegeneration in adulthood (SENDA) is a recently established disorder that is a subtype of neurodegeneration with brain iron accumulation (NBIA). We ...
Known for Static Encephalopathy | Diffusion Tensor | Childhood Neurodegeneration | Imaging Findings

De Novo Mutations In The Autophagy Gene Wdr45 Cause Static Encephalopathy Of...

[ PUBLICATION ] ... cause static encephalopathy of childhood with neurodegeneration in adulthood. WDR45 encodes a homolog of the yeast autophagy protein Atg18.
Known for Novo Mutations | Static Encephalopathy | Autophagy Gene | Wdr45 Encodes

Delayed-Onset Dystonia In Patients With "static" Encephalopathy.

[ PUBLICATION ] . Eight cases of persistent dystonia appearing one to 14 years after non-progressive cerebral insults are described. Five were due to perinatal anoxia, one to trauma, and two to cerebral ...
Known for Static Encephalopathy | Onset Dystonia | Cerebral Infarction | Brain Injuries

First Video Report Of Static Encephalopathy Of Childhood With Neurodegeneration...

[ PUBLICATION ]
Known for Static Encephalopathy | Video Report | Childhood Neurodegeneration | Neurodegenerative Diseases

Course Of Schizophrenia: Neuropsychological Evidence For A Static Encephalopathy.

[ PUBLICATION ] ... a static encephalopathy. Review of longitudinal and cross-sectional studies strongly supports the latter interpretation. In particular, we present data from a recent cross-sectional study ...
Known for Neuropsychological Evidence | Static Encephalopathy | Cognitive Function | Tests Schizophrenia

Memory And Intellectual Deficits Do Not Decline With Age In Schizophrenia

[ PUBLICATION ] ... a static encephalopathy than a dementing disorder. This study investigates memory and intellectual decline in 62 chronic schizophrenic subjects using the Wechsler Adult Intelligence ...
Known for Intellectual Deficits | Age Schizophrenia | Static Encephalopathy | Memory Disorders

Management Of Status Dystonicus: Our Experience And Review Of The Literature

[ PUBLICATION ] ... with static encephalopathy, and the other one in a patient with pantothenate kinase-associated neurodegeneration. Both patients were admitted to an intensive care unit and treated with ...
Known for Status Dystonicus | Intensive Unit | Acute Worsening | Static Encephalopathy

Age And Neuropsychologic Function In Schizophrenia: A Decline In Executive...

[ PUBLICATION ] ... a static encephalopathy or a deterioration of brain function, or periods of each condition. Assessments of cognitive function, as measured by neuropsychologic assessment, can provide ...
Known for Patients Schizophrenia | Executive Functions | Cognitive Function | Age Effects

Analysis Of The C19orf12 And Wdr45 Genes In Patients With Neurodegeneration With...

[ PUBLICATION ] ... named static encephalopathy in childhood with neurodegeneration in adulthood (also called BPAN); however, analysis of this gene in a broader spectrum of NBIA has not been reported yet.
Known for Brain Iron Accumulation | Wdr45 Gene | Heterozygote Humans | Mutations C19orf12

3-Methyl Glutaconic Aciduria In Iraqi Jewish Children May Be Misdiagnosed As...

[ PUBLICATION ] ... a static encephalopathy causing a non-progressive disorder of posture and/or movement. We describe 7 patients from 5 families who were initially diagnosed with cerebral palsy. Eventually, ...
Known for Cerebral Palsy | Static Encephalopathy | Nonprogressive Disorder | Inborn Errors

Recently Asked Questions

Static Encephalopathy Static encephalopathy is a type of brain damage that results in a loss of neurological function. This can be caused by a variety of factors, including...