Robert H. Purcell

Robert H. Purcell

Department Of Microbiology, Georgetown University, Rockville, Md 20852.

Direct Impact

Concepts for which Robert H Purcell has direct influence:

hepatitis virus
hepatocellular carcinoma
monoclonal antibodies
avian hev
rhesus monkeys
hcv infection
nucleotide sequence

External impact

Concepts related to the work of other authors for which Robert H Purcell has influence:

viral kinetics
hepatitis virus
hcv infection
hepatocellular carcinoma
virological tools
blood donors
electron microscopy

Prominent publications by Robert H. Purcell

KOL-Index: 165 The chimpanzee as a model for the study of NANBH in the pre-HCV eraPhysico-chemical properties of the NANB agentThe role of the animal model in the discovery of hepatitis C virusGenetic variabilityThe contribution of the animal model to the study of the natural history of HCV infectionMonoclonal HCV infection in chimpanzeesHCV and fulminant hepatitisInteractions among hepatitis viruses in ...
Known for
Model Natural | History Hcv
KOL-Index: 85 Historical perspectivesClinical features of hepatitis AOutcome of diseaseHepatitis A in pregnancyHepatitis A in pre-existing liver diseaseHepatitis A and autoimmune liver diseaseHepatitis A and extrahepatic diseaseHepatitis A and human immunodeficiency virus (HIV) infectionOther associated diseasesHistopathologyPathogenesisAnimal models of hepatitis A
Known for
Autoimmune Liver Diseasehepatitis | Historical Perspectivesclinical Features | Diseaseshistopathologypathogenesisanimal Models
KOL-Index: 62 Hepatitis C virus (HCV) infection is a leading cause of chronic liver diseases worldwide, but treatment options are limited. Basic HCV research required for vaccine and drug development has been hampered by inability to culture patient isolates, and to date only the JFH1 (genotype 2a) recombinant replicates spontaneously in hepatoma cells and releases infectious virus. A JFH1 chimera with ...
Known for
Full-Length J6 Propagation | 2a Strain | Hepatoma Cells | Virus Jfh1
KOL-Index: 45 Several useful animal models for both hepatitis A and E have been identified, characterized, and refined. At present, all of the best models utilize nonhuman primates: chimpanzees, tamarin species, and owl monkeys for hepatitis A; and macaque species, chimpanzees, and owl monkeys for hepatitis E. Pigs may prove useful for some studies of hepatitis E, and it is hoped that serological evidence ...
Known for
Rats Hepatitis | Chimpanzees Owl
KOL-Index: 45 BACKGROUND: Hepatitis E virus (HEV) is a common cause of acute viral hepatitis (AVH) in many developing countries. In Egypt, HEV seroprevalence is among the highest in the world; however, only a very limited number of Egyptian HEV sequences are currently available. OBJECTIVES: The objectives were to determine the HEV genotype(s) currently circulating in Egypt. STUDY DESIGN: AVH patients ...
Known for
North African Isolates | Serologic Acute | Egyptian Hev Sequences | Viremia
KOL-Index: 34 We analyzed the humoral immune response elicited by hepatitis C virus (HCV) E2 protein expressed in vivo after injection of plasmid DNA into mice and rhesus macaques. Three plasmids were used for immunization: a plasmid containing the entire sequence of the E2 and p7 genes (pE2); a plasmid encoding a truncated form of the E2 protein targeted to the cell surface (pE2surf); a control plasmid ...
Known for
Immunized Pe2 | Mice Macaques | Entire Sequence
KOL-Index: 33 Hepatitis E virus (HEV), a positive-strand RNA agent, has been associated with enterically transmitted non-A, non-B hepatitis in Asia, Africa, and Mexico. To evaluate the role of HEV in an outbreak of hepatitis in Pakistan, we used immune electron microscopy to detect 1) antibody to HEV, for evidence of infection, and 2) virus, to determine the pattern of HEV excretion. Paired sera from 2 ...
Known for
10 85 | Jaundice Feces | Positive-Strand Rna Agent | Acute Icteric Hepatitis
KOL-Index: 32 The recent development of safe and effective inactivated hepatitis A virus vaccines provides for the first time the opportunity to control hepatitis A. However, control will depend upon the intelligent use of the vaccines. How and when hepatitis A vaccines should be used will be determined from the results of studies of the levels and duration of protective antibody, determination of optimum ...
KOL-Index: 32 Most structural information about poliovirus interaction with neutralizing antibodies was obtained in the 1980s in studies of mouse monoclonal antibodies. Recently we have isolated a number of human/chimpanzee anti-poliovirus antibodies and demonstrated that one of them, MAb A12, could neutralize polioviruses of both serotypes 1 and 2. This communication presents data on isolation of an ...
Known for
Cryo-Em | Cellular Poliovirus Receptor Cd155 | Cross Neutralizing | Serotypes Poliovirus

Department of Microbiology, Georgetown University, Rockville, MD 20852.

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