Dagny Holle

Dagny Holle

Department of Neurology, West German Headache Center, University hospital Essen, Essen, Germany | Department of Neurology and Centre for Translational Neuro‐ and Behavioural ...

KOL Resume for Dagny Holle  (headache, cluster headache syndrome, cluster, syndrome, cluster syndrome)


Department of Neurology, West German Headache Center, University hospital Essen, Essen, Germany


Department of Neurology, West German Headache Center, University Hospital Essen, Essen, Germany


Department of Neurology, University Hospital Essen, Germany.


Department of Neurology, University Hospital Essen, Essen, Germany.


Department of Neurology and Westgerman Headache Center, University of Duisburg-Essen, Essen, Germany.


Universitätsklinik für Neurologie, Kopfschmerz- und Schwindelzentrum Essen


Department of Neurology and West-German Headache Center, University of Duisburg-Essen, Essen, Germany


University of Duisburg-Essen, Department of Neurology, Hufelandstr. 55, 45122 Essen, Germany +49 201 723 84385; +49 201 723 5542;


Department of Neurology and Headache Center, University Hospital Essen, Germany


Department of Neurology, University Hospital Essen, Hufelandstraße 55, 45122, Essen, Germany

Universitätsklinik für Neurologie, Westdeutsches Kopfschmerzzentrum, Universitätsklinikum Essen, Hufelandstr. 55, 45147, Essen, Deutschland


From the Department of Neurology (D.H., C.G., S.Z., S.N., S.K., H.-C.D., Z.K., M.O.), University of Duisburg-Essen, Essen; and Interdisciplinary Pain Center (H.K.), University of Freiburg, Freiburg, Germany.

University Hospital Essen, Germany


Department of Neurology, University of Duisburg-Essen, Hufelandstrasse 55, 45122, Essen, Germany

Westdeutsches Kopfschmerzzentrum, Klinik für Neurologie, Universität Duisburg-Essen, Hufelandstr. 26, Duisburg-Essen, Deutschland


Westdeutsches Kopfschmerzzentrum, Neurologische Klinik, Universitätsklinikum Essen, Hufelandstraße 26, 45147, Essen, Deutschland

Department of Neurology and Headache Centre, University Duisburg-Essen, 45147, Essen, Germany


From the Departments of Neurology (M.O., K.N., C.S., D.H., M.M., H.-C.D., Z.K.) and Neuroradiology (E.R.G.), University of Duisburg-Essen; Department of Neurology and Neurophysiology (M.M.), Bruederkrankenhaus Trier, Germany; and Department of Neurology (P.J.G.), University of California, San Francisco.

Departments of Neurology, University of Duisburg-Essen, Essen, Bürgerhospital Stuttgart, Stuttgart, University of Greifswald, Greifswald, Krankenhaus München-Harlaching, München, and, University of Magdeburg, Magdeburg, Germany


Dept. of Neurology, University Hospital Essen, Hufelandstr. 55, 45122, Essen, Germany


Prominent publications by Dagny Holle

KOL Index score: 10161

BACKGROUND: Transcatheter aortic valve implantation (TAVI) is associated with a higher risk of neurological events for both the transfemoral and transapical approach than surgical valve replacement. Cerebral magnetic resonance imaging has revealed more new, albeit clinically silent lesions from procedural embolization, yet the main source and predominant procedural step of emboli remain unclear.

METHODS AND RESULTS: Eighty-three patients underwent transfemoral (Medtronic CoreValve ...

Known for Valve Implantation |  Cerebral Embolization |  Procedural Hits |  Transfemoral Tavi |  Transcatheter Aortic
KOL Index score: 9689

BackgroundCalcitonin gene related peptide (CGRP) monoclonal antibodies (mAB) are the first specific migraine prophylactic medication. Erenumab is the only CGRP mAB targeting the CGRP receptor. Clinical data regarding efficacy and tolerability of erenumab in highly therapy-refractory patients are not available, yet, although many patients treated with CGRP mAB under real world conditions can be considered as highly therapy-refractory.MethodsClinical routine data of highly ...

Known for Migraine Patients |  3 Months |  Gene Peptide |  Monoclonal Antibodies |  Cgrp Receptor
KOL Index score: 9316

BACKGROUND: Transcranial direct current stimulation (tDCS) of the primary motor cortex has been shown to modulate pain and trigeminal nociceptive processing.

METHODS: Ten patients with classical trigeminal neuralgia (TN) were stimulated daily for 20 minutes over two weeks using anodal (1 mA) or sham tDCS over the primary motor cortex (M1) in a randomized double-blind cross-over design. Primary outcome variable was pain intensity on a verbal rating scale (VRS 0-10). VRS and attack ...

Known for Trigeminal Neuralgia |  Current Stimulation |  Transcranial Direct |  Primary Motor Cortex |  Pain Intensity
KOL Index score: 8870

Trigeminal neuralgia (TN) is supposedly caused by an ectatic blood vessel affecting the trigeminal nerve at the root entry zone of the brain stem. Recent evidence suggests an additional central component within trigeminal pain-processing in the pathophysiology of TN. Therefore, we aimed to identify specific brain regions possibly associated with the development or maintenance of TN using magnetic resonance imaging (MRI) voxel-based morphometry (VBM). Sixty patients with classical TN were ...

Known for Chronic Pain |  Trigeminal Neuralgia |  Gray Matter |  Volume Reduction |  Patients Healthy Controls
KOL Index score: 8509

BACKGROUND: Right-to-left cardiac shunt (RLS) is considered a risk factor for stroke, especially in patients aged <55 years. We aimed to investigate the current management and prognosis in consecutive patients with RLS and otherwise cryptogenic cerebrovascular events.

METHODS: In total, 1,126 patients with cryptogenic stroke or TIA were included from 17 German neurology departments. During a mean follow-up of 28.4 months, we assessed current antithrombotic medication, percutaneous device ...

Known for Recurrent Stroke |  Cardiac Catheterization |  Cerebrovascular Events |  Secondary Prevention |  Patients Cryptogenic
KOL Index score: 8248

INTRODUCTION: Data on clinical differences between episodic (eCH) and chronic cluster headache (cCH) and accompanying migraine features are limited.

METHODS: History and clinical features of 209 consecutive cluster headache patients (144 eCH, 65 cCH; male:female ratio 3.4 : 1) were obtained in a tertiary headache centre by face-to-face interviews. Relationship between occurrence of accompanying symptoms, pain intensity, comorbid migraine, and circannual and circadian rhythmicity was ...

Known for Cluster Headache |  Comorbid Migraine |  Clinical Characteristics |  Pain Intensity |  Attacks Patients
KOL Index score: 7973

BACKGROUND: Episodic cluster headache (ECH) is a primary headache disorder that severely impairs patient's quality of life. First-line therapy in the initiation of a prophylactic treatment is verapamil. Due to its delayed onset of efficacy and the necessary slow titration of dosage for tolerability reasons prednisone is frequently added by clinicians to the initial prophylactic treatment of a cluster episode. This treatment strategy is thought to effectively reduce the number and ...

Known for Cluster Headache |  Oral Prednisone |  Prophylactic Treatment |  Efficacy Safety |  Controlled Trial
KOL Index score: 7968

Migraine is a common neurological disorder, characterised by severe headaches. Epidemiological studies in the USA and Europe have identified a subgroup of migraine patients with chronic migraine. Chronic migraine is defined as ≥15 headache days per month for ≥3 months, in which ≥8 days of the month meet criteria for migraine with or without aura, or respond to treatment specifically for migraine. Chronic migraine is associated with a higher burden of disease, more severe psychiatric ...

Known for Chronic Migraine |  Primary Physicians |  15 Headache |  Global Health |  Cost Illness
KOL Index score: 7806

BACKGROUND: Although up to 15% of patients with whiplash injury develop chronic headache, the basis and mechanisms of this posttraumatic headache are not well understood.

METHODS: Thirty-two patients with posttraumatic headache following whiplash injury were investigated within 14 days after the accident and again after 3 months using magnetic resonance-based voxel-based morphometry. Twelve patients developed chronic headache lasting longer than 3 months and were studied a third time ...

Known for Gray Matter |  Posttraumatic Headache |  3 Months |  Whiplash Injury |  Patients Chronic
KOL Index score: 7530

We aimed to investigate the prevalence of cardiac right left shunts (RLS) in population-based samples of subjects with migraine with aura (n = 42), migraine without aura (n = 44) and controls without headache (n = 41). Cardiac RLS was assessed with transcranial Doppler sonography with intravenous injection of saline. Prevalence of RLS was highest in migraineurs with aura (45.2%) compared to migraineurs without aura (34.1%) and controls (41.5%). Permanent as opposed to latent RLS was more ...

Known for Migraine Aura |  Prevalence Rls |  Patent Humans |  Case Control |  Foramen Ovale
KOL Index score: 7372

Brain derived neurotrophic factor (BDNF) is associated with pain modulation and central sensitization. Recently, a role of BDNF in migraine and cluster headache pathophysiology has been suspected due to its known interaction with calcitonin gene-related peptide. Bi-center prospective study was done enrolling four diagnostic groups: episodic migraine with and without aura, episodic cluster headache, frequent episodic tension-type headache, and healthy individuals. In migraineurs, venous ...

Known for Primary Headaches |  Neurotrophic Factor |  Migraine Attacks |  Cluster Headache |  Brain Derived
KOL Index score: 6241

BACKGROUND: Prednisone is commonly used for initial short-term therapy of episodic cluster headaches before preventive medication such as verapamil becomes effective, but this strategy has not been tested in large randomised trials. We aimed to access the safety and efficacy of this treatment approach.

METHODS: This study was a multicentre, randomised, double-blind, placebo-controlled trial done in ten specialised headache centres in Germany. Patients with episodic cluster headaches who ...

Known for Cluster Headache |  Drug Therapy |  Patients Episodic |  Calcium Channel
KOL Index score: 5969

OBJECTIVE: The study was conducted to investigate the after-effect of transcranial direct current stimulation (tDCS) applied over the human primary motor cortex (M1) on trigeminal and extracranial nociceptive processing.

BASIC PROCEDURES: Nineteen healthy volunteers were stimulated using cathodal, anodal (both 1 mA) or sham tDCS for 20 minutes. Pain processing was assessed by recording trigeminal and extracranial pain-related evoked potentials (PREPs) following electrical stimulation of ...

Known for Motor Cortex |  Current Stimulation |  Transcranial Direct |  Cathodal Anodal |  Nociceptive Processing

Vestibular migraine

KOL Index score: 5944

BACKGROUND: The combination of vertigo, dizziness and balance disturbance with migraine is called vestibular migraine. Although it is estimated that up to 1% of the population suffers from this disease, it is still widely unknown and often underdiagnosed. Recently, the International Headache Society and the Báràny Society published the first joint document with mutually accepted diagnostic criteria for vestibular migraine.

METHOD: This review summarizes current knowledge on vestibular ...

Known for Vestibular Migraine |  Differential Diagnosis |  Clinical Presentation |  Vertigo Dizziness |  Therapeutic Recommendations
KOL Index score: 5922

BACKGROUND: The connection of cluster headache (CH) attacks with rapid eye movement (REM) sleep has been suggested by various studies, while other authors challenge this assumption. We performed serial polysomnography to determine the association of nocturnal CH attacks and sleep.

METHODS: Five patients diagnosed with CH (two with the episodic and three with the chronic subtype) were included and studied over four consecutive nights to evaluate connections between attacks onset and sleep ...

Known for Cluster Headache |  Attacks Sleep |  Rapid Eye Movement |  Aged Polysomnography |  Disordered Breathing


Dagny Holle: Influence Statistics

Sample of concepts for which Dagny Holle is among the top experts in the world.
Concept World rank
headache attacks patients #1
hypothalamus neuroimaging #1
strong coffee #2
16 erenumab #2
migraine attacks pregnancy #2
vm patients hc #2
treatment pathway monoclonal #2
break cgrp #2
association hypothalamic dysfunction #2
strictly sleep #2
causal relationship epiphenomenon #2
studies hypothalamic involvement #2
mmd monthly #2
age 174 cases #2
9 fremanezumab #2
accompanying migraine #2
hypothalamus causal relationship #2
therapeutic response caffeine #2
treatment treatment break #2
sickness vm #2
sensitized rotatory #2
principal question alterations #2
association hypnic headache #2
circadian circannual rhythmicity #2
months cgrp #2
instant chronification method #2
pain headache disorders #2
14 mmds #2
electrophysiology studies effectiveness #2
7 galcanezumab #2
46 migraine patients #2
headache rare #2
headache entity time #2
invasive treatment methods #2
erenumab highly #2
symptomatic headache types #2
drug resistant migraine #2
sickness rating scale #2
mandatory break pathway #2
treatment cgrp monoclonal #2
14 episodic migraine #2
prophylactic agent review #2
mandatory treatment break #2
data cerebral imaging #2
cup strong #2

Key People For Cluster Headache

Top KOLs in the world
Peter James Goadsby
cluster headache chronic migraine acute treatment
Arne May
cluster headache migraine patients chronic pain
Gennaro Bussone
cluster headache chronic migraine medication overuse
Anish Bahra
cluster headache brain cancer hemicrania continua
Karl Ekbom
cluster headache basilar artery lifetime prevalence
Gian Camillo Manzoni
cluster headache chronic migraine psychiatric comorbidity

Dagny Holle:Expert Impact

Concepts for whichDagny Hollehas direct influence:Cluster headache,  Hypnic headache,  Chronic migraine,  Vestibular migraine,  Trigeminal neuralgia,  Episodic cluster headache,  Headache disorders,  Recurrent stroke.

Dagny Holle:KOL impact

Concepts related to the work of other authors for whichfor which Dagny Holle has influence:Cluster headache,  Chronic migraine,  Aortic valve,  Trigeminal neuralgia,  Neuropathic pain,  Medication overuse,  Patent foramen.



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Department of Neurology, West German Headache Center, University hospital Essen, Essen, Germany | Department of Neurology and Centre for Translational Neuro‐ and Behavioural Sciences (C‐TNBS), West German Headache Center, University Hospital Essen, U

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