Pavel Mares̆: Influence Statistics

Pavel Mares̆

Pavel Mares̆

Department of Developmental Epileptology, Institute of Physiology, Czech Academy of Sciences, 14220 Prague, Czech Republic;, Pavel.Mares@fgu.cas.cz, (P.M.);, ...

Pavel Mares̆: Expert Impact

Concepts for which Pavel Mares̆ has direct influence: Immature rats , Anticonvulsant action , Status epilepticus , Epileptic afterdischarges , Clonic seizures , Developing rats , Wistar receptors .

Pavel Mares̆: KOL impact

Concepts related to the work of other authors for which for which Pavel Mares̆ has influence: Status epilepticus , Immature rats , Kainic acid , Infantile spasms , Antiepileptic drugs , Absence epilepsy , Glutamate receptors .

KOL Resume for Pavel Mares̆

Year
2021

Department of Developmental Epileptology, Institute of Physiology, Czech Academy of Sciences, 14220 Prague, Czech Republic;, (P.M.);, (L.K.);, (A.M.)

Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 14220 Prague, Czech Republic;, (P.M.);, (K.V.);, (H.K.);, (K.V.)

2020

Institute of Physiology, Academy of Sciences of the Czech Republic, 14220 Prague, Czech Republic;,

2019

Department of Developmental Epileptology, Institute of Physiology, Czech Academy of Sciences, Prague, Czechia

2018

Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czechia

2016

Department of Developmental Epileptology, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic.

2015

Institute of Physiology, Academy of Sciences of the Czech Republic, Prague, Czech Republic

2014

Department of Developmental Epileptology, Institute of Physiology, Academy of Sciences, Czech Republic

2013

Department of Developmental Epileptology, Institute of Physiology ASCR, Videnska 1083, CZ-142 20 Prague 4, Czech Republic

2011

Department of Pathophysiology, 3rd Medical Faculty, Charles University, Prague, Czechoslovakia

Institute of Physiology, Czechoslovak Academy of Sciences

2010

Dept. Developmental Epileptology, Institute of Physiology, Academy of Sciences of the Czech Republic, Vídenská 1083, CZ-14220 Prague 4, Czech Republic

2009

Institute of Physiology ASCR, Prague, Czech Republic.

Charles University, Second Medical Faculty, Prague, Czech Republic

SUNY, Downstate Medical Center, Brooklyn, New York, U.S.A

2008

Department of Developmental Epileptology, Institute of Physiology, Academy of Sciences of the Czech Republic, Vídeňská 1083, CZ 142 20, Prague 4, Czech Republic

2007

Institute of Physiology, Academy of Sciences, Prague, Czech Republic

2006

Institute of Physiology, Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague 4, Czech Republic

University of Kuopio, Kuopio, Finland

Albert Einstein College of Medicine, Bronx, New York

2005

Institute of Physiology, Academy of Sciences of the Czech Republic, Department of Developmental Epileptology, Vídeňská 1083, CZ 142 20 Prague 4, Czech Republic

2004

Institute of Physiology, Academy of Sciences of the Czech Republic, Vı́deňská 1083, CZ 142 20 Prague 4, Czech Republic

2003

Institute of Physiology, Academy of Sciences of the Czech Republic, Vı́denská 1083, 142 20 Prague 4, Czech Republic

2002

Institute of Physiology, Academy of Sciences of the Czech Republic, Vı́denská 1083, CZ 142 20 Prague 4, Czech Republic

2001

Department of Neurophysiology of Memory, Institute of Physiology, Academy of Sciences of the Czech Republic, VÍdeňská 1083, 142 20 Prague, Czech Republic

2000

Institute of Physiology, Academy of Sciences of the Czech Republic, Vı́deňská 1083, 142 20, Prague 4, Czech Republic

1999

Institute of Physiology, Academy of Sciences of the Czech Republic

1998

Institute of Physiology, Academy of Sciences of the Czech Republic, Prague.

1997

Department of Pathological Physiology, Third Medical School, Charles University, Prague, Czech Republic

1996

Department of Pathophysiology of the 3rd Medical Faculty, Charles University, Prague, Czech Republic

1995

Institute of Physiology, Czechoslovak Academy of Sciences Prague, Czech Republic

1994

Department of Pathophysiology, 3rd Medical Faculty, Charles University, Prague, Czech Republic Czech Republic

1993

Departments of Pharmacology, Pathophysiology, 3rd Medical Faculty, Charles University, Prague, Czech Republic

Institute of Physiology, Czechoslovak Academy of Sciences, Prague, Czechoslovakia

Prominent publications by Pavel Mares̆

KOL-Index: 11573 . An antagonist of type I metabotropic glutamate receptors MPEP was found to exhibit anticonvulsant action in adult rodents. Present experiments were focused on action of this drug against pentetrazol-induced motor seizures in immature rats 12-, 18- and 25-days old. Dose of pentetrazol (100 mg/kg s.c.) was chosen to elicit minimal clonic seizures and (after a longer latency) generalized ...
Known for Immature Rats | Anticonvulsant Action | Glutamate Receptors | Drug Epilepsy
KOL-Index: 11553 . Previous studies demonstrated that selected agonists for metabotropic glutamate group II and group III receptors can provide protection against seizures in adult animals. The present study has examined the potential effect of some of these compounds on seizures induced in immature rats by intracerebroventricular infusion of DL-homocysteic acid (DL-HCA, 600 nmol/side). Rat pups were ...
Known for Metabotropic Glutamate | Immature Rats | Homocysteic Acid | Wistar Receptors
KOL-Index: 11289 . The present study has examined the anticonvulsant and neuroprotective effect of group II metabotropic glutamate receptor (mGluR) agonist (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylate (2R,4R-APDC) in the model of seizures induced in immature 12-day-old rats by bilateral intracerebroventricular infusion of dl-homocysteic acid (DL-HCA, 600 nmol/side). For biochemical analyses, rat pups were ...
Known for Immature Rats | Homocysteic Acid | Metabotropic Glutamate | 2r4r Apdc
KOL-Index: 11158 . The present study has examined the effect of free radical spin trap N-tert-butyl-alpha-phenylnitrone (PBN) in the model of seizures induced in immature 12-day-old rats by bilateral intracerebroventricular infusion of dl-homocysteic acid (dl-HCA, 600 nmol/side). PBN was given i.p. in two doses (100 mg/kg each), 30 min prior and 30 min after dl-HCA infusion. PBN did not significantly ...
Known for Immature Rats | Homocysteic Acid | Seizures Induced | Free Radical
KOL-Index: 10028 . PURPOSE: Antagonists of group I metabotropic glutamate receptors (mGluRs) are known to exhibit anticonvulsant action without serious side effects. Recently we found anticonvulsant effects of specific antagonists of mGluR subtypes 1 and 5 (AIDA and MTEP) against pentetrazol-induced convulsions in developing rats. In order to determine if the effects of these two antagonists are not ...
Known for Glutamate Receptors | Immature Rats | Wistar Receptor | Aida Doses
KOL-Index: 9935 . Antagonists of type I of metabotropic glutamate receptors exhibit anticonvulsant action in adult as well as immature rodents. To know the anticonvulsant profile of a specific mGluR5 antagonist MPEP in developing rats, two models of epileptic seizures were used. MPEP (10, 20 or 40 mg/kg i.p.) suppressed in a dose-dependent manner epileptic afterdischarges induced by electrical stimulation ...
Known for Anticonvulsant Action | Metabotropic Glutamate | Immature Rats | Animal Doseresponse Relationship
KOL-Index: 9814 . The potential anticonvulsant effect of group III metabotropic glutamate receptor (mGluR) agonist (R,S)-4-phosphonophenylglycine ((R,S)-PPG) against seizures induced in immature 12-day-old rats by bilateral intracerebroventricular (icv) infusion of DL-homocysteic acid (DL-HCA, 600 nmol/side) was examined in the present study. Rat pups were sacrificed during generalized clonic-tonic ...
Known for Immature Rats | Homocysteic Acid | Metabotropic Glutamate | Wistar Receptors
KOL-Index: 9761 . Glutamate is the main excitatory neurotransmitter in the brain and ionotropic glutamate receptors mediate the majority of excitatory neurotransmission (Dingeldine et al. 1999). The high level of glutamatergic excitation allows the neonatal brain (the 2(nd) postnatal week in rat) to develop quickly but it also makes it highly prone to age-specific seizures that can cause lifelong ...
Known for Ampa Receptors | Status Epilepticus | Subunit Composition | Immature Rats
KOL-Index: 9685 . Bilateral intracerebroventricular infusion of dl-homocysteic acid (DL-HCA) (600 nmol on each side) to immature 12-day-old rats induced generalized clonic-tonic seizures, recurring frequently for at least 90 min, with a high rate of survival. Electrographic recordings from sensorimotor cortex, hippocampus, and striatum demonstrated isolated spikes in the hippocampus and/or striatum as the ...
Known for Immature Rats | Homocysteic Acid | Wistar Receptors | Seizures Induced
KOL-Index: 9290 . PURPOSE: To study the possible relation between spontaneous recurrent seizures (SRS) and the derangement of cognitive memory. METHODS: Status epilepticus (SE) was induced in adult Long-Evans rats by pilocarpine (320 mg/kg, i.p.) and interrupted after 2 h by clonazepam (CZPs mg/kg, i.p.). In addition to the animals that were given pilocarpine and CZP (group P), two groups received ketamine ...
Known for Status Epilepticus | Cognitive Functions | Spontaneous Recurrent Seizures | Animals Pilocarpine
KOL-Index: 8615 . GYKI 52466 (1-(4-aminophenyl)-4-methyl-7,8-methylendioxy-5H-2,3-benzo-diaz epi ne), a non-competitive non-NMDA receptor antagonist, was tested against epileptic afterdischarges elicited by cortical stimulation in 12-, 18- and 25-day-old rats with implanted electrodes. Shortening of afterdischarges and a decrease in intensity of clonic movements accompanying both stimulation and ...
Known for Gyki 52466 | Cortical Afterdischarges | Immature Rats | Wistar Receptors
KOL-Index: 8188 . GABA(B) receptors mediate inhibition at early stages of development but mixed anti-and proconvulsant action of their agonists affecting all receptors was found in immature rats. Positive allosteric modulators of GABA(B) receptors potentiate only already active GABA(B) receptors and therefore more specific action is expected. Possible anticonvulsant action of CGP7930 was studied in a model ...
Known for Anticonvulsant Action | Gabab Receptor | Immature Rats | Tonic Phase
KOL-Index: 8177 . The direct injection of endothelin-1 (ET-1) into brain parenchyma was recently suggested as a suitable model of stroke. The present study was designed to assess whether intrahippocampal injection of ET-1 in immature rats causes neurodegeneration and immediate seizures, and results in impairment of motor development, cognitive decline, epilepsy and chronic hippocampal lesion. ET-1 was ...
Known for Immature Rats | Intrahippocampal Injection | P12 P25 | Development Epilepsy
KOL-Index: 8145 . Electrical stimulation of sensorimotor cortex was used to study early and late effects of administration of kainic acid in a dose (6 mg/kg i.p.) eliciting only nonconvulsive seizures in rats. Thresholds for elicitation of four phenomena--movements directly related to stimulation; epileptic afterdischarges (ADs) of the spike-and-wave type; clonic seizures accompanying these ADs; and mixed ...
Known for Kainic Acid | Sensorimotor Cortex | Electrical Stimulation | Thresholds Phenomena

Key People For Immature Rats

Top KOLs in the world
#1
Pavel Mares̆
immature rats anticonvulsant action status epilepticus
#2
Hana Kubová
immature rats status epilepticus anticonvulsant action
#3
Solomon L Moshe´
status epilepticus substantia nigra infantile spasms
#4
Yehezkel Ben‐Ari
kainic acid wistar receptors mossy fibers
#5
Gregory L Holmes
status epilepticus neonatal seizures kainic acid
#6
A LEWIS FARR
quantitative histochemistry glucuronidase hydrolysis brain iii

Department of Developmental Epileptology, Institute of Physiology, Czech Academy of Sciences, 14220 Prague, Czech Republic;, Pavel.Mares@fgu.cas.cz, (P.M.);, luciee.kozlova@gmail.com, (L.K.);, anna.mikulecka@fgu.cas.cz, (A.M.) | Department of Develop