Lawrence Joseph Wheat

Lawrence Joseph Wheat

Department Of Medicine And Pathology, Indiana University Medical Center, Wishard Memorial Hospital, Usa Veterans Administration Hospital, Indianapolis, Indiana Usa

Direct Impact

Concepts for which Lawrence Joseph Wheat has direct influence:

disseminated histoplasmosis
histoplasma capsulatum
liposomal amphotericin
cerebrospinal fluid
enzyme immunoassay
fungal infections
acquired immunodeficiency syndrome

External impact

Concepts related to the work of other authors for which Lawrence Joseph Wheat has influence:

disseminated histoplasmosis
histoplasma capsulatum
liposomal amphotericin
diagnostic accuracy
cerebrospinal fluid
acquired immunodeficiency syndrome
prospective multicenter

Prominent publications by Lawrence Joseph Wheat

KOL-Index: 69 We reviewed the clinical, microbiologic, and outcome characteristics of 72 patients with human immunodeficiency virus (HIV)-associated histoplasmosis (4 newly described) reported in Europe over 20 years (1984-2004). Seven cases (9.7%) were acquired in Europe (autochthonous), whereas the majority involved a history of travel or arrival from endemic areas. The diagnosis of progressive ...
KOL-Index: 61 Background: Accurate and timely methods for the diagnosis of histoplasmosis in resource-limited countries are lacking. Histoplasma antigen detection by enzyme immunoassay (EIA) is widely used in the United States (US) but not in resource-limited countries, leading to missed or delayed diagnoses and poor outcomes. Lateral flow assays (LFAs) can be used in this setting. Methods: Frozen urine ...
Known for
Resource Limited | Mvista | Proven Disseminated | 3 Centers
KOL-Index: 48 To evaluate the efficacy of paromomycin for the treatment of symptomatic cryptosporidial enteritis in human immunodeficiency virus-infected adults, we conducted a prospective, randomized, double-blind, placebo-controlled trial before the widespread introduction of highly active antiretroviral therapy (HAART). Seven units under the auspices of the AIDS Clinical Trials Group enrolled 35 adults ...
Known for
Cryptosporidial Enteritis | Paromomycin Therapy | Arm Cryptosporidiosis | Effective Symptomatic
KOL-Index: 47 In the USA, histoplasmosis is generally thought to occur mainly in the Ohio and Mississippi river valleys, and the classic map of histoplasmosis distribution reflecting this is second nature to many US physicians. With the advent of the HIV pandemic, reports of patients with progressive disseminated histoplasmosis and AIDS came from regions of known endemicity, as well as from regions not ...
Known for
Progressive Disseminated Histoplasmosis | Geographic Location | Immune Suppression | Constellations
KOL-Index: 46 Histoplasmosis is an endemic mycosis caused by Histoplasma capsulatum. Infection develops by inhalation of microconidia from environmental sites inhabited by birds and bats. Disseminated disease is the usual presentation due to impaired cellular immunity. Common clinical manifestations include fever, fatigue, malaise, anorexia, weight loss, and respiratory symptoms. Histoplasma antigen ...
KOL-Index: 43 Histoplasmosis is a global disease endemic to regions of all six inhabited continents. The areas of highest endemicity lie within the Mississippi and Ohio River Valleys of North America and parts of Central and South America. As a result of climate change and anthropogenic land utilization, the conditions suitable for Histoplasma capsulatum are changing, leading to a corresponding change in ...
Known for
Management Histoplasmosis
KOL-Index: 41 During a Histoplasma outbreak in a colony of fruit bats at a southern United States zoo, it was observed that although Histoplasma was recovered in culture from multiple sites at necropsy, none of the samples collected from those bats tested positive for Histoplasma antigen (HAg). Five of the Histoplasma isolates from the bats were subsequently identified as Latin American (LA) clade A, ...
Known for
Isolates Recovered | Bat Host | Hag Infected | Histoplasma Rflp
KOL-Index: 39 Evidence-based guidelines for the management of patients with histoplasmosis were prepared by an Expert Panel of the Infectious Diseases Society of America. These updated guidelines replace the previous treatment guidelines published in 2000 (Clin Infect Dis 2000; 30:688-95). The guidelines are intended for use by health care providers who care for patients who either have these infections ...
Known for
Antifungal Agents | Inflammatory Disorders | Evidence-Based Guidelines | Infectious America
KOL-Index: 36 Infective endocarditis is an uncommon manifestation of infection with Histoplasma capsulatum. The diagnosis is frequently missed, and outcomes historically have been poor. We present 14 cases of Histoplasma endocarditis seen in the last decade at medical centers throughout the United States. All patients were men, and 10 of the 14 had an infected prosthetic aortic valve. One patient had an ...
Known for
Clue | 11 Months | Lifelong | Oral Itraconazole Therapy
KOL-Index: 36 Understanding the uses and limitations of a battery of laboratory methods is essential to diagnose histoplasmosis. Antigen detection and serology are valuable adjuncts to histopathology and culture. Improvements incorporated into the second-generation Histoplasma antigen assay have increased its sensitivity and specificity for diagnosis of histoplasmosis. More recently, the antigen assay has ...
Known for
Understanding Limitations | Methods Histoplasmosis | Histopathology Culture | Improvements Diagnosis

Department of Medicine and Pathology, Indiana University Medical Center, Wishard Memorial Hospital, USA Veterans Administration Hospital, Indianapolis, Indiana USA

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