Yoshi Nagahata

Yoshi Nagahata

First Department Of Surgery, Kobe University School Of Medicine, 7-5-2 Kusunoki-Cho, Chuo-Ku, 650, Kobe, Japan

Direct Impact

Concepts for which Yoshi Nagahata has direct influence:

ischemic colitis
stress ulcer
gastric mucosal blood flow
residual gastritis
hepatic regeneration
biliary drainage
helicobacter pylori

External impact

Concepts related to the work of other authors for which Yoshi Nagahata has influence:

gastric juice
ischemic colitis
stress ulcer
blood flow
hepatic regeneration
cirrhotic livers
simultaneous determination

Prominent publications by Yoshi Nagahata

KOL-Index: 37 We investigated the response of gastric vessels to prostaglandin (PG) E2 after intra-duodenal release of bile in rats with obstructive jaundice. The animals were divided into four groups according to duration of bile duct obstruction (BDO): control and 1 week (W), 2W, and 3W groups. Prolonged BDO decreased gastric mucosal blood flow (BF) significantly. The BF recovered after the release of ...
Known for
Bdo Decreased | Pge2 Content | Groups Response | Persistent Jaundice
KOL-Index: 34 PURPOSE: Ischemic colitis develops after a sudden decrease in colonic blood supply and has a variety of clinical manifestations. The aim of this study was to assess the role of platelet activating factor in the pathogenesis of ischemic colitis with use of the platelet activating factor antagonist TCV-309. METHODS: Rats were randomly divided into four groups. Rats in Group RV underwent ring ...
Known for
Platelet Activating Factor Antagonist | Severity Lesion | Colon Rats | Role Ischemic
KOL-Index: 32 We experimentally studied the influence of vagotomy on hepatic regeneration in rats after hepatectomy of cirrhotic livers. In animals that underwent hepatectomy plus vagotomy the reduction in gastric pH was suppressed, but gastric mucosal blood flow was less than that in control animals that received hepatectomy alone. The suppression of 3H-thymidine uptake percentage and thymidine kinase ...
Known for
Treated Hepatectomy | Livers Animals | Peak Level | Vagotomy Gastric
KOL-Index: 25 Patients with "reflux" gastritis after gastrectomy suffer from a variety of symptoms, and this type of gastritis may sometimes compromise the quality of life of these patients. Since Helicobacter pylori is considered to be one of the most important pathogenetic factors in gastritis, the association between H. pylori and reflux gastritis was investigated in this study. A total of 145 patients ...
Known for
Fifty-Two | Upper Gastrointestinal Endoscopy | Symptoms Gastritis | Pathogenetic
KOL-Index: 21 The inhibitory mechanism of dopamine (DA) on rat gastric motility was investigated in association with DA receptors. Gastric movement was assessed according to the method of Jacoby et al and was expressed with the system of Ludwick et al. (1968). DA inhibited gastric movement in both the corpus and antrum in a dose-dependent manner. Domperidone, a specific antagonist of DA2 receptor, ...
Known for
Receptor Da1 | Motility Da2 | Movement Dependent
KOL-Index: 16 In this report, we briefly present the case of a 67-year-old woman who developed recurrent glucagonoma with lymph node metastasis. An immunohistochemical study of the metastatic tumor revealed immunoreactivity of glucagon and protein kinase C (PKC)-α, -β, and -γ in the tumor cells, two types of which were seen by electron microscopy. One type had abundant secretory granules and mitochondria, ...
Known for
Metastatic Tumor | Cells Granules | Recurrent Glucagonoma | Pkc Subspecies
KOL-Index: 15 Protein kinase C [cPKC: α, β (βI βII), γ], a Ca2+- and phospholipid-dependent enzyme, has been thought to play a critical role in the synthesis and secretion of gut hormones in gastrointestinal mucosa. However, the localization of PKC has not yet been clarified at the cellular level in the gastrointestinal epithelium. The present study was made to identify cPKC-containing cells ...
Known for
Hormones Pkc | G- | Duodenal Epithelial Cells | Granulated
KOL-Index: 15 The effects of dopamine (DA) on the prostaglandin (PG) E2 content of rat gastric mucosa was investigated. There was a 17.5% increase in gastric mucosal blood flow (BF) after administration of DA (5 μ/kg/min iv). After pretreatment with fusaric acid (FA), an antagonist of dopamine ß hydroxylase, DA increased BF by 27.8%. The PGE2 content in DA and DA + FA groups increased at rates of 45.8% ...
Known for
Basso’s Method | Rat Gastric Mucosa | Prostaglandin Pg Content | Increased Pge2 Synthesis
KOL-Index: 14 The influence of 16,16-dimethyl prostaglandin E2 (16,16-dm PGE2; an agent used for the prevention of stress ulcer after hepatectomy of the cirrhotic liver) on liver regeneration after hepatectomy was studied in rats. The following results were obtained. Ulceration after the stress of 6 h of water immersion was markedly suppressed in rats treated with 30 r/kg of 16,16-dmPGE2 as compared with ...
Known for
Water Immersion | Animals Treated | Dmpge2 Prevention | Indomethacin-Induced
KOL-Index: 13 Upper gastrointestinal hemorrhage occurs occasionally in the time of surgery or biliary infection in patients with obstructive jaundice. In the present study, the influence of obstructive jaundice and biliary drainage on the rat gastric mucosa was examined. Serum t-Bil, GOT and Alp increased during obstructive jaundice, but decreased following biliary drainage. Hexose and fucose levels in ...
Known for
Hexose | 2-Week Jaundiced | Rat Gastric Mucosa | Isolated Gastric Vascular Perfusion

First Department of Surgery, Kobe University School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, 650, Kobe, Japan

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