Chikako Nishigori: Influence Statistics

Chikako Nishigori

Chikako Nishigori

Division of Research on Intractable Dermatological Disease, Department of iPS cell Applications, Kobe University Graduate School of Medicine, Kobe, Japan | Division of ...

Chikako Nishigori: Expert Impact

Concepts for which Chikako Nishigori has direct influence: Xeroderma pigmentosum , Cholinergic urticaria , P53 gene , Autologous sweat , Skin cancer , Melanoma cells , Japanese patients .

Chikako Nishigori: KOL impact

Concepts related to the work of other authors for which for which Chikako Nishigori has influence: Xeroderma pigmentosum , Dna damage , Oxidative stress , Skin cancer , Blau syndrome , Ultraviolet radiation , Melanoma cells .

KOL Resume for Chikako Nishigori

Year
2022

Division of Research on Intractable Dermatological Disease, Department of iPS cell Applications, Kobe University Graduate School of Medicine, Kobe, Japan

2021

Kobe University Graduate School of Medicine

2020

Graduate School of Medicine, Kobe University, Kobe, Hyogo, Japan

2019

Division of Dermatology, Department of Internal related, Kobe University Graduate School of Medicine, Kobe, Japan

2018

Department of Dermatology, Graduate School of Medicine, Kobe University, Kobe, Japan

2017

Division of Dermatology, Department of Internal Related Kobe University Graduate School of Medicine KobeJapan

Department of Dermatology, the Graduate School of Medicine, Kobe University, Kobe, Japan

2016

Division of Dermatology Department of Internal Related Medicine, Faculty of Medicine Kobe University Graduate School of Medicine Kobe Japan

2015

Kobe University Graduate School of Medicine Division of Dermatology Department of Internal Related Kobe Japan

2014

Division of Dermatology, Kobe University Hospital, 7-5-2 Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Japan

2013

Kobe University Graduate School of Medicine Division of Dermatology, Department of Internal Related, Kobe Japan

2012

Division of DermatologyDepartment of Internal RelatedGraduate School of MedicineKobe UniversityKobeJapan

From the Department of Dermatology, Kobe University Graduate School of Medicine, Kobe, Japan

2011

Division of Dermatology, School of Medicine, Kobe University, Kobe 657-8501, Japan

2010

Division of Dermatology, Department of Internal Related (Drs Sakaguchi, Nagai, and Nishigori), and Division of Clinical Pathology and Immunology, Department of Internal Medicine (Drs Tsuji, Morinobu, and Kumagai), Kobe University Graduate School of Medicine, Kobe, Japan.

2009

Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe 650-0017

Department of Dermatology, Kobe University, Kobe, Japan

2008

Division of Dermatology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.

2007

Division of Dermatology, Clinical Molecular Medicine, Faculty of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan

Prominent publications by Chikako Nishigori

KOL-Index: 15125 . The transcription factor signal transducer and activator of transcription 3 (STAT3) has two important phosphorylation sites, Tyr705 and Ser727, for its activation. Ser727 phosphorylation has been considered to be a secondary event after Tyr705 phosphorylation. In this study, the role and regulation of Ser727 phosphorylation in STAT3 in melanocytic cells were examined. STAT3 was ...
Known for Melanoma Cells | Stat3 Phosphorylation | Nuclear Translocation | Cell Survival
KOL-Index: 13078 . Hand-foot skin reaction is a most common multi-kinase inhibitor-related adverse event. This study aimed to examine whether the toxicity of sorafenib and sunitinib for human keratinocytes was associated with inhibiting signal transduction and activator of transcription 3 (STAT3). We studied whether STAT3 activity affects sorafenib- and sunitinib-induced cell growth inhibition in HaCaT cells ...
Known for Sorafenib Sunitinib | Signal Transduction | Hacat Cells | Transcription 3
KOL-Index: 12344 . BACKGROUND: Current treatment with biologics has produced dramatic therapeutic effects in patients with psoriasis, although these agents occasionally decrease in efficacy. One of the main factors responsible for this attenuation is attributed to the development of antidrug antibodies (ADAs). OBJECTIVES: To analyse the relationship between serum drug concentrations, the presence of ADAs and ...
Known for Adalimumab Infliximab | Monoclonal Antibodies | Treatment Psoriasis | Patients Adas
KOL-Index: 12315 . CD4(+)CD25(+) T cells are an important population that plays a crucial role in the maintenance of peripheral self-tolerance. Recently, it was shown that the elimination of these cells by in vivo administration of anti-CD25 monoclonal antibody (mAb) caused the regression of highly immunogenic tumors in syngeneic mice. In this study, we examined whether B16F10 melanoma cells regressed with ...
Known for Tumor Cells | B16f10 Melanoma | Cell Depletion | Skin Neoplasms
KOL-Index: 11743 . Src homology 2 domain-containing protein tyrosine phosphatase substrate 1 (SHPS-1) is a member of the signal regulatory protein family in which the extracellular region interacts with its ligand, CD47. Recent studies have demonstrated that SHPS-1 plays an important role in cell migration and cell adhesion. We demonstrate in this study, using immunohistochemical and flow cytometric ...
Known for Langerhans Cells | Lymph Nodes | Monoclonal Antigens | Tyrosine Phosphatase
KOL-Index: 11172 . BACKGROUND: It has been reported that patients with cholinergic urticaria have a type 1 allergy to autologous sweat; however, the pathogenesis of that disorder has not been fully elucidated. OBJECTIVE: We investigated the responsiveness to autologous sweat and serum in patients with cholinergic urticaria in relation to their clinical characteristics. We further classified the clinical ...
Known for Autologous Sweat | Cholinergic Urticaria | Serum Patients | Positive Reactions
KOL-Index: 10522 . Xeroderma pigmentosum (XP) patients in Tunisia who belong to the genetic complementation group A (XPA) have milder skin symptoms than do Japanese XPA patients. Such difference in the clinical features might be caused by the difference in the site of mutation in the XP A-complementing (XPAC) gene. The purpose of this study is to identify the genetic alterations in the XPAC gene in the ...
Known for Point Mutation | Xeroderma Pigmentosum | Xpa Patients | Exon 6
KOL-Index: 10317 . The hepatocyte growth factor (HGF) signaling pathway was examined in human normal melanocytes and three malignant melanoma cell lines. HGF-induced activation of c-Met, its receptor-tyrosine kinase, was observed in both melanocytes and melanoma cells, whereas phosphatidylinositol 3-kinase (PI3K), a downstream target of c-Met, was not activated in the melanocytes but enhanced in the melanoma ...
Known for Melanoma Cells | Protein Kinase | Hepatocyte Growth | Phosphatidylinositol 3
KOL-Index: 9916 . UV exposure induces skin cancer, in part, by inducing immune suppression. Repairing DNA damage, neutralizing the activity of cis-urocanic acid, and reversing oxidative stress abrogate UV-induced immune suppression and skin cancer induction, suggesting that DNA, UCA, and lipid photo-oxidation serve as UV photoreceptors. What is not clear is whether signaling through each of these different ...
Known for Dna Repair | Immune Suppression | Oxidative Stress | Skin Cancer
KOL-Index: 9757 . We identified seven novel germline mutations of the PTCH gene in eight unrelated Japanese patients with nevoid basal cell carcinoma syndrome (NBCCS). In order to ensure genetic diagnosis, all 23 coding exons of the PTCH gene were amplified from genomic DNA by polymerase chain reaction (PCR) and sequenced. Mutations were found in all eight patients with NBCCS. The mutations detected in this ...
Known for Ptch Gene | Germline Mutations | Cell Carcinoma | Nevoid Basal
KOL-Index: 9601 . UV irradiation interferes with the induction of T cell-mediated immune responses, in part by causing cells in the skin to produce immunoregulatory cytokines. Recent evidence implicates UV-induced DNA damage as a trigger for the cascade of events leading to systemic immune suppression in vivo. However, to date, there has been no direct evidence linking DNA damage and cytokine production in ...
Known for Dna Damage | Inbred Balb Mice | Murine Keratinocytes | Cells Skin
KOL-Index: 9334 . BackgroundSignal transducer and activator of transcription (STAT)3 is a reported mediator of molecular-targeted drug-induced keratinocyte toxicity.AimOur purpose was to assess the association of single nucleotide polymorphisms (SNPs) in STAT3 with hand-foot skin reactions (HFSR) in patients with metastatic renal cell carcinoma (mRCC) treated with multiple tyrosine kinase inhibitors ...
Known for Cell Carcinoma | Single Nucleotide Polymorphisms | Retrospective Analysis | Kinase Inhibitors
KOL-Index: 9144 . Keratinocytes are the major target of sunlight, and they produce prostaglandin (PG) E2 upon ultraviolet (UV) exposure. Although indomethacin, one of cyclooxygenase inhibitors, is known to suppress UV-induced acute skin inflammation, it remains uncertain whether endogenous PGE2 is responsible for UV-induced skin inflammation, and which subtype of PGE2 receptors mediates this process. ...
Known for Induced Skin | Ep4 Receptors | Blood Flow | Uv Exposure
KOL-Index: 8838 . Phototherapy with narrow-band UVB (NB-UVB), with a peak exclusively at 311 nm wavelength, has been found to be more effective in treating a variety of skin diseases than conventional broad-band UVB (BB-UVB). To assess the difference in carcinogenic activity between NB-UVB and BB-UVB, we investigated skin tumor formation by irradiating albino hairless, Ogg1 knockout mice and C57BL/6J wild ...
Known for Cyclobutane Pyrimidine Dimer | Nb Uvb | Cpd Formation | Skin Tumor

Key People For Xeroderma Pigmentosum

Top KOLs in the world
#1
Kenneth H Kraemer
xeroderma pigmentosum dna repair skin cancer
#2
Alan Robert LEHMANN
xeroderma pigmentosum dna repair cockayne syndrome
#3
James E Cleaver
xeroderma pigmentosum dna repair ultraviolet light
#4
Dirk Bootsma
xeroderma pigmentosum dna repair human chromosome
#5
Jay H Robbins
xeroderma pigmentosum dna repair cockayne syndrome
#6
Jan H J Hoeijmakers
dna repair xeroderma pigmentosum cockayne syndrome

Division of Research on Intractable Dermatological Disease, Department of iPS cell Applications, Kobe University Graduate School of Medicine, Kobe, Japan | Division of Dermatology, Kobe University Graduate School of Medicine, Kobe, Japan | Division o