Mikiko Tohyama: Influence Statistics

Mikiko Tohyama

Mikiko Tohyama

Department of Dermatology, Ehime University Graduate School of Medicine, Ehime, Japan | Department of Dermatology, National Hospital Organization Shikoku Cancer Center, ...

Mikiko Tohyama: Expert Impact

Concepts for which Mikiko Tohyama has direct influence: Human herpesvirus , Keratinocyte migration , Epidermal keratinocytes , Hypersensitivity syndrome , Involucrin expression , Fibroblast migration , Dihs dress .

Mikiko Tohyama: KOL impact

Concepts related to the work of other authors for which for which Mikiko Tohyama has influence: Systemic symptoms , Human herpesvirus , Drug reaction , Wound healing , Atopic dermatitis , Antimicrobial peptides , Hypersensitivity syndrome .

KOL Resume for Mikiko Tohyama

Year
2022

Department of Dermatology, Ehime University Graduate School of Medicine, Ehime, Japan

2021

Department of Dermatology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime, Japan; Department of Dermatology, Ehime University Graduate School of Medicine, Ehime, Japan. Electronic address:

2020

Department of Dermatology, National Hospital Organization Shikoku Cancer Center, Ehime, Japan.

2019

Department of Dermatology, National Hospital Organization Shikoku Cancer Center, Matsuyama‐city, Japan

2018

Department of Dermatology, Ehime University Graduate School of Medicine, 454 Shitsukawa, Toon-shi, Ehime 791-0295, Japan

2017

Department of Dermatology Ehime University Graduate School of Medicine Ehime Japan

2016

Department of Dermatology, Ehime University Graduate School of Medicine, Japan

2015

Department of Dermatology, Ehime University Graduate School of Medicine, Matsuyama, Japan

2014

Ehime University Graduate School of Medicine Department of Dermatology Matsuyama Japan

2013

Department of Dermatology, Ehime University School of Medicine, Ehime, Japan

2012

Dermatology (M.T., K.H.), Ehime University Graduate School of Medicine, To-on, Ehime, 791-0295 Japan

2011

Department of Dermatology, Ehime University Graduate School of Medicine, Shitsukawa, Toon City, Ehime 791-0295, Japan

2010

Department of Dermatology, Showa University School of Medicine, and, Department of Biochemical Toxicology, School of Pharmaceutical Sciences, Showa University, Tokyo, Department of Dermatology, Ehime University Graduate School of Medicine, Toon, Department of Occupational and Environmental Health, Nagoya City University Graduate School of Medical Sciences, and, Department of Occupational and Environmental Health, Nagoya University Graduate School of Medicine, Nagoya, Japan

2009

Department of Dermatology, Ehime University Graduate School of Medicine.

2008

Department of Dermatology, Ehime University Graduate School of Medicine, Toon-city, Ehime 791-0295, Japan

2007

Department of Dermatology, Ehime University Graduate School of Medicine.

2006

Department of Dermatology, Ehime University School of Medicine, Shitsukawa, Toon, Ehime, Japan

2005

Ehime University, School of Medicine Department of Dermatology Tou‐on Japan

2004

Department of Dermatology, Ehime University School of Medicine, Onsengun, Ehime 791-0295, Japan

2003

Department of Dermatology, Ehime University School of Medicine, Shitsukawa, Shigenobucho, Onsengun, Ehime, Japan

2001

Department of Dermatology, Ehime University School of Medicice.

1998

Department of Dermatology, Ehime University School of Medicine, Japan.

Prominent publications by Mikiko Tohyama

KOL-Index: 18742 . The role of angiotensin II (Ang II) in the control of systemic blood pressure and volume homeostasis is well known and has been extensively studied. Recently, Ang II was suggested to also have a function in skin wound healing. In the present study, the in vivo function of Ang II in skin wound healing was investigated using Ang II type 1 receptor (AT1R) knock-out mice. Wound healing in ...
Known for Wound Healing | Growth Factor | Egf Receptor | Keratinocyte Migration
KOL-Index: 15051 . Toll-like receptor (TLR)3 is a receptor for virus-associated double-stranded RNA, and triggers antiviral immune responses during viral infection. Epidermal keratinocytes express TLR3 and provide an innate immune defense against viral infection. Since the intracellular regulatory mechanism is unknown, we hypothesized that the signal transducers and activators of transcription ...
Known for Human Keratinocytes | Innate Immune | Stat1 Activation | Tolllike Receptor
KOL-Index: 14871 . The closure of skin wounds is essential for resistance against microbial pathogens, and keratinocyte migration is an important step in skin wound healing. Cathelicidin hCAP18/LL-37 is an innate antimicrobial peptide that is expressed in the skin and acts to eliminate microbial pathogens. Because hCAP18/LL-37 is up-regulated at skin wound sites, we hypothesized that LL-37 induces ...
Known for Keratinocyte Migration | Antimicrobial Peptide | Growth Factor | Egfr Transactivation
KOL-Index: 14587 . Hepatocyte growth factor (HGF) is a potent mitogen for mature hepatocytes. Because HGF has strong effects on the motility of keratinocytes and is produced by fibroblasts, HGF is thought to regulate keratinocyte migration during wound healing. However, the intracellular signaling mechanism of HGF-induced keratinocyte migration is poorly understood. In this report, we clarify the roles of ...
Known for Keratinocyte Migration | Stat3 Phosphorylation | Socs3 Cis3 | Negative Regulation
KOL-Index: 12656 . BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disorder caused by multiple factors. Among them, house dust mite (HDM) allergens are important in the development of AD. In airway allergy, HDM allergens activate innate immunity. However, information regarding the activation of innate immunity by HDM allergens in the skin is limited. OBJECTIVES: The inflammasome is a key ...
Known for Danger Signal | Activation Nlrp3 Inflammasome | House Dust Mite | Innate Immunity
KOL-Index: 12225 . BACKGROUND: Drug-induced hypersensitivity syndrome (DIHS)/drug rash with eosinophilia and systemic symptoms (DRESS) is a serious acute drug reaction with fever, cutaneous eruption, lymphadenopathy, and several visceral dysfunctions. Eosinophilia is a common hematological abnormality in DIHS/DRESS suggesting that the Th2-type immune response is involved. Thymus and activation-regulated ...
Known for Patients Dihs | Systemic Symptoms | Serum Tarc Levels | Hypersensitivity Syndrome
KOL-Index: 12095 . Epidermal keratinocytes differentiate and form a multilayered epidermis, which is the primary barrier between the body and the outer environment. As the epidermis is constantly exposed to a variety of microbial pathogens, its function of resisting microbial pathogens is vital. This characteristic feature is formed during differentiation. Immunohistochemical analysis revealed that the upper ...
Known for Innate Immunity | Messenger Receptors | Epidermal Keratinocytes | Keratinocyte Differentiation
KOL-Index: 12046 . PURPOSE OF REVIEW: The similarity between viral skin eruption and drug-induced rash has inspired many researchers to seek an association between viral infection and drug allergy. Hypersensitivity syndrome (referred to in this review as drug-induced hypersensitivity syndrome) is one of the severe adverse reactions to drugs and was reported more than 50 years ago. However, the mechanism of ...
Known for Human Herpesvirus | Drug Allergy | Hypersensitivity Syndrome | 6 Reactivation
KOL-Index: 11639 . BACKGROUND: Drug-induced hypersensitivity syndrome (DIHS) is an adverse reaction with clinical signs of fever, rash and internal organ involvement. In the vast majority of patients in Japan, the causative drugs for DIHS are limited to the following eight: carbamazepine, phenytoin, phenobarbital, zonisamide, mexiletine, dapsone, salazosulfapyridine and allopurinol. The association of human ...
Known for Human Herpesvirus | Hhv6 Reactivation | Hypersensitivity Syndrome | Symptoms Fever
KOL-Index: 11382 . BACKGROUND: thymus and activation-regulated chemokine (TARC)/CCL17 is a CC chemokine that selectively attracts Th2-type lymphocytes. Immunohistochemical analyses have revealed that TARC is expressed in the epidermal keratinocytes of atopic dermatitis (AD), suggesting TARC involvement in the pathogenesis of the disease. However, keratinocyte TARC production has been described only in the ...
Known for Hacat Cells | Ccl17 Production | Tarc Protein | Ifngamma Tnfalpha
KOL-Index: 11152 . Transforming growth factor-beta-activated kinase 1 (TAK1) is a member of the mitogen-activated protein (MAP) kinase family and is an upstream signaling molecule of nuclear factor-kappaB (NF-kappaB). Given that NF-kappaB regulates keratinocyte differentiation and apoptosis, TAK1 may be essential for epidermal functions. To test this, we generated keratinocyte-specific TAK1-deficient mice ...
Known for Kinase 1 | Growth Factor | Differentiation Apoptosis | Deficient Mice
KOL-Index: 11024 . BACKGROUND: Bone morphogenetic protein-2 (BMP-2) and Wnt are involved in the normal development and tumorigenesis of several organs, and in the development of skin and skin appendages as a morphogen. However, the crosstalk between BMP-2 and the Wnt/beta-catenin signaling pathway is not clear. OBJECTIVE: We examined BMP-2-dependent expression of Wnt and its receptor frizzled in normal human ...
Known for Bone Morphogenetic | Wnt Signaling | Expression Bmp2 | Factor Beta
KOL-Index: 9669 . Platelet-derived growth factor (PDGF) is involved in wound healing, but PDGF-induced fibroblast migration and the intracellular signaling mechanisms of fibroblast migration are poorly understood. Signal transducer and activator of transcription 3 (STAT3) is involved in migration and is negatively regulated by the suppressor of cytokine signaling 3 (SOCS3). We studied the PDGF induction of ...
Known for Cytokine Signaling | Socs3 Pdgf | Wound Healing | Growth Factor
KOL-Index: 9608 . The recruitment of immature dendritic cells into the epidermis is a key step in the development of cutaneous immunity, although the mechanism remains to be clarified. Recently, it was reported that both macrophage inflammatory protein 3alpha (MIP-3alpha)/CCL20 produced by keratinocytes and TNF-alpha are important in recruiting Langerhans cells (LC) to the epidermis. In this study, we ...
Known for Macrophage Inflammatory | Messenger Receptors | Langerhans Cells | Potent Chemokine

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Department of Dermatology, Ehime University Graduate School of Medicine, Ehime, Japan | Department of Dermatology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Japan | Department of Dermatology, National Hospital Organization Shik