Vivette Denise D'Agati

Vivette Denise D'Agati

Department Of Pathology, College Of Physicians And Surgeons, Columbia University, 701 W. 168th Street, 10032, New York, New York, Usa

Direct Impact

Concepts for which Vivette Denise D'Agati has direct influence:

lupus nephritis
nephrotic syndrome
focal segmental glomerulosclerosis
hiv-associated nephropathy
renal ischemia
reperfusion injury
polycystic kidney

External impact

Concepts related to the work of other authors for which Vivette Denise D'Agati has influence:

nephrotic syndrome
acute kidney injury
focal segmental glomerulosclerosis
iga nephropathy
lupus nephritis
renal biopsy
mesangial cells

Prominent publications by Vivette Denise D'Agati

KOL-Index: 260
KOL-Index: 79 Focal segmental glomerulosclerosis (FSGS) is a leading cause of nephrotic syndrome and end-stage renal disease worldwide. Although the mechanisms underlying this important disease are poorly understood, the glomerular podocyte clearly plays a central role in disease pathogenesis. In the current work, we demonstrate that the homophilic adhesion molecule sidekick-1 (sdk-1) is up-regulated in ...
Known for
Direct Interaction | Beta-Catenin | Focal Segmental Glomerulosclerosis | Nephrotic Syndrome End-Stage Renal
KOL-Index: 73
Known for
Familial Iga Nephropathy
KOL-Index: 72 HIV-positive individuals are at increased risk for kidney disease, including HIV-associated nephropathy, noncollapsing focal segmental glomerulosclerosis, immune-complex kidney disease, and comorbid kidney disease, as well as kidney injury resulting from prolonged exposure to antiretroviral therapy or from opportunistic infections. Clinical guidelines for kidney disease prevention and ...
Known for
Therapy Hiv | Prevention Define
KOL-Index: 71 Recent years have brought notable progress in the field of IgA nephropathy. Here, we highlight important new directions and latest developments, including successful discovery of several genetic susceptibility loci, formulation of the multihit pathogenesis model, introduction of the Oxford pathology scoring system, and formalization of the Kidney Disease Improving Global Outcomes (KDIGO) ...
Known for
Formalization | Latest Developments | Interpopulation Allelic Differentiation | Intestinal Immune Network
KOL-Index: 67 BACKGROUND: To gain insight into the pathogenesis of collapsing glomerulopathy, a rare form of FSGS that often arises in the setting of viral infections, we performed a genome-wide association study (GWAS) among inbred mouse strains using a murine model of HIV-1 associated nephropathy (HIVAN). METHODS: We first generated F1 hybrids between HIV-1 transgenic mice on the FVB/NJ background and ...
Known for
Model Hiv-1 | Strains Performed | Lmx1b Transcriptional | Gene Ssbp2
KOL-Index: 66 Key PointsThe incidence of obesity-related glomerulopathy (ORG) is increasing in parallel with the worldwide obesity epidemicPathologic features of ORG include glomerulomegaly and focal segmental glomerulosclerosis (FSGS), particularly the perihilar variant; the degree of foot process effacement in ORG is usually less than in primary FSGSSubnephrotic proteinuria is the most common clinical ...
Known for
Responses Renal | Glomerulopathy Org | Proteinuria Fsgs
KOL-Index: 66 The acute loss of kidney function has been diagnosed for many decades using the serum concentration of creatinine — a muscle metabolite that is an insensitive and non-specific marker of kidney function, but is now used for the very definition of acute kidney injury (AKI). Fortunately, myriad new tools have now been developed to better understand the relationship between acute tubular injury ...
Known for
Insensitive Non-Specific Marker | Phenotyping | Kidney-Derived Molecules | Gene Transcripts
KOL-Index: 62 RATIONALE & OBJECTIVES: Glomerular diseases, including minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and immunoglobulin A (IgA) nephropathy, share clinical presentations, yet result from multiple biological mechanisms. Challenges to identifying underlying mechanisms, biomarkers, and new therapies include the ...
Known for
Curegn Rationale

Department of Pathology, College of Physicians and Surgeons, Columbia University, 701 W. 168th Street, 10032, New York, New York, USA

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