Hao Sun: Influence Statistics

Hao Sun

Hao Sun

Department of Chemical Pathology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong 999077, China. | Department of Chemical Pathology, ...

Hao Sun: Expert Impact

Concepts for which Hao Sun has direct influence: Maternal plasma , Plasma dna , Muscle regeneration , Maternal plasma dna , Massively parallel sequencing , Skeletal myogenesis , Transcription factors .

Hao Sun: KOL impact

Concepts related to the work of other authors for which for which Hao Sun has influence: Gene expression , Skeletal muscle , Maternal plasma , Liquid biopsy , Tumor dna , Prenatal diagnosis , Transcription factors .

KOL Resume for Hao Sun

Year
2022

Department of Chemical Pathology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong 999077, China.

2021

Department of Chemical Pathology, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, Hong Kong SAR, China

2020

Department of Chemical Pathology, Li Ka Shing Institute of Health Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China

2019

Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong, China

2018

Department of Chemical Pathology, Li Ka Shing Institute of Health Sciences, the Chinese University of Hong Kong, 999077, Hong Kong, China

Li Ka Shing Institute of Health Sciences The Chinese University of Hong Kong Shatin Hong Kong

2017

Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China

2016

Department of Chemical Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China

2015

Department of Chemical Pathology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China

2014

Department of Chemical Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, NT, Hong Kong SAR, China;

Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China

Li Ka Shing Institute of Health Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong Special Administrative Region

2013

Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, and

Departments of Chemical Pathology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, China

2012

Prince of Wales Hospital, Hong Kong, China

Li Ka Shing Institute of Health Sciences and

Departments of Chemical Pathology,

2011

Department of Chemical Pathology, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China

Centre for Research into Circulating Fetal Nucleic Acids Li Ka Shing Institute of Health Sciences

2010

Centre for Research into Circulating Fetal Nucleic Acids, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong SAR, China.

Center for Systems and Computational Biology, Molecular and Cellular Oncogenesis Program, The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104 and, Human Cancer Genetics, Comprehensive Cancer Center, Dept. of Mol. Virology, Immunology & Med. Genetics, Ohio State University, 460 W 12th Avenue, BRT, Columbus, OH 43210, USA

2009

The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA

2008

Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA

2007

Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics

2006

Human Cancer Genetics Program, Comprehensive Cancer Center, Department of Molecular Virology, Immunology and Medical Genetics (S.K.P., H.S., R.V.D.), Department of Plant Cellular and Molecular Biology (S.J., R.S.L., E.G.), and Plant Biotechnology Center (S.J.), The Ohio State University, Columbus, Ohio 43210

2005

Department of Molecular Virology, Immunology and Medical Genetics, Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio Stage University, 420 W 12th Avenue, TMRF 524, Columbus, OH 43210, USA

2004

2003

Human Cancer Genetics Program, Comprehensive Cancer Center, Dept. of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA

1999

State Key Laboratory of Pollution Control and Resource Reuse, Department of Environmental Science and Engineering, Nanjing University, Nanjing 210093, P. R. China

Prominent publications by Hao Sun

KOL-Index: 14459 . BACKGROUND: The gene regulatory information is hardwired in the promoter regions formed by cis-regulatory elements that bind specific transcription factors (TFs). Hence, establishing the architecture of plant promoters is fundamental to understanding gene expression. The determination of the regulatory circuits controlled by each TF and the identification of the cis-regulatory sequences ...
Known for Transcription Factors | Gene Regulatory | Promoter Regions | Agris Databases
KOL-Index: 13087 . Massively parallel sequencing of DNA molecules in the plasma of pregnant women has been shown to allow accurate and noninvasive prenatal detection of fetal trisomy 21. However, whether the sequencing approach is as accurate for the noninvasive prenatal diagnosis of trisomy 13 and 18 is unclear due to the lack of data from a large sample set. We studied 392 pregnancies, among which 25 ...
Known for Trisomy 18 | Noninvasive Prenatal Diagnosis | Dna Sequencing | Pregnant Women
KOL-Index: 11534 . OBJECTIVES: To validate the clinical efficacy and practical feasibility of massively parallel maternal plasma DNA sequencing to screen for fetal trisomy 21 among high risk pregnancies clinically indicated for amniocentesis or chorionic villus sampling. DESIGN: Diagnostic accuracy validated against full karyotyping, using prospectively collected or archived maternal plasma samples. SETTING: ...
Known for Trisomy 21 | Dna Sequencing | Maternal Plasma | Positive Predictive
KOL-Index: 11443 . Noninvasive prenatal testing using fetal DNA in maternal plasma is an actively researched area. The current generation of tests using massively parallel sequencing is based on counting plasma DNA sequences originating from different genomic regions. In this study, we explored a different approach that is based on the use of DNA fragment size as a diagnostic parameter. This approach is ...
Known for Plasma Dna | Noninvasive Prenatal | Sensitivity Specificity | Molecular Diagnostics
KOL-Index: 11401 . BACKGROUND: Noninvasive prenatal diagnosis of trisomy 21 (T21) has recently been shown to be achievable by massively parallel sequencing of maternal plasma on a sequencing-by-synthesis platform. The quantification of several other human chromosomes, including chromosomes 18 and 13, has been shown to be less precise, however, with quantitative biases related to the chromosomal GC ...
Known for Noninvasive Prenatal Diagnosis | Massively Parallel Sequencing | Maternal Plasma Dna | Trisomy 21
KOL-Index: 11315 . BACKGROUND: Plasma DNA obtained from a pregnant woman contains a mixture of maternal and fetal DNA. The fetal DNA proportion in maternal plasma is relatively consistent as determined using polymorphic genetic markers across different chromosomes in euploid pregnancies. For aneuploid pregnancies, the observed fetal DNA proportion measured using polymorphic genetic markers for the aneuploid ...
Known for Plasma Dna | Fetal Trisomy | Parallel Sequencing | Allelic Ratio Analysis
KOL-Index: 11066 . We performed a high-resolution analysis of the biological characteristics of plasma DNA in systemic lupus erythematosus (SLE) patients using massively parallel genomic and methylomic sequencing. A number of plasma DNA abnormalities were found. First, aberrations in measured genomic representations (MGRs) were identified in the plasma DNA of SLE patients. The extent of the aberrations in ...
Known for Plasma Dna | Sle Patients | Lupus Erythematosus | Methylation Epigenesis
KOL-Index: 11033 . Gene regulatory pathways converge at the level of transcription, where interactions among regulatory genes and between regulators and target genes result in the establishment of spatiotemporal patterns of gene expression. The growing identification of direct target genes for key transcription factors (TFs) through traditional and high-throughput experimental approaches has facilitated the ...
Known for Regulatory Networks | Transcription Factors | Target Genes | Arabidopsis Thaliana
KOL-Index: 10687 . We explored the detection of genome-wide hypomethylation in plasma using shotgun massively parallel bisulfite sequencing as a marker for cancer. Tumor-associated copy number aberrations (CNAs) could also be observed from the bisulfite DNA sequencing data. Hypomethylation and CNAs were detected in the plasma DNA of patients with hepatocellular carcinoma, breast cancer, lung cancer, ...
Known for Plasma Dna | Cancer Detection | Sensitivity Specificity | Bisulfite Sequencing
KOL-Index: 10578 . Skeletal muscle cell differentiation (myogenesis) is a process orchestrated by a complex network involving transcription factors, epigenetic regulators, and microRNAs. Previous studies identified miR-29 as a pro-myogenic factor that interacts with components of Polycomb repressive complex, YY1 and Ezh2. In a genome-wide survey of miR-29-mediated transcriptome changes in C2C12 myoblasts, ...
Known for Skeletal Myogenesis | Zeste Homolog | Binding Protein | Transcription Factors
KOL-Index: 9968 . MOTIVATION: The fractional fetal DNA concentration is one of the critical parameters for non-invasive prenatal diagnosis based on the analysis of DNA in maternal plasma. Massively parallel sequencing (MPS) of DNA in maternal plasma has been demonstrated to be a powerful tool for the non-invasive prenatal diagnosis of fetal chromosomal aneuploidies. With the rapid advance of MPS ...
Known for Maternal Plasma | Fetal Dna | Targeted Mps | Parallel Sequencing
KOL-Index: 9850 . BACKGROUND: Fetal DNA in maternal urine, if present, would be a valuable source of fetal genetic material for noninvasive prenatal diagnosis. However, the existence of fetal DNA in maternal urine has remained controversial. The issue is due to the lack of appropriate technology to robustly detect the potentially highly degraded fetal DNA in maternal urine. METHODOLOGY: We have used ...
Known for Fetal Dna | Pregnant Women | Massively Parallel | Nucleotide Sequencing
KOL-Index: 9607 . BACKGROUND: Analysis of circulating RNA in the plasma of pregnant women has the potential to serve as a powerful tool for noninvasive prenatal testing and research. However, detection of circulating RNA in the plasma in an unbiased and high-throughput manner has been technically challenging. Therefore, only a limited number of circulating RNA species in maternal plasma have been validated ...
Known for Maternal Plasma | Rna Sequencing | Pregnancy Trimester | Pregnant Women
KOL-Index: 9507 . BACKGROUND: Epigenetic mechanisms play an important role in prenatal development, but fetal tissues are not readily accessible. Fetal DNA molecules are present in maternal plasma and can be analyzed noninvasively. METHODS: We applied genomewide bisulfite sequencing via 2 approaches to analyze the methylation profile of maternal plasma DNA at single-nucleotide resolution. The first approach ...
Known for Maternal Plasma | Bisulfite Sequencing | Fetal Dna | Noninvasive Prenatal
KOL-Index: 9430 . Cell-free DNA (cfDNA) in human plasma is a class of biomarkers with many current and potential future diagnostic applications. Recent studies have shown that cfDNA molecules are not randomly fragmented and possess information related to their tissues of origin. Pathologies causing death of cells from particular tissues result in perturbations in the relative distribution of DNA from the ...
Known for Chromatin Regions | Dna Fragmentation | Plasma Cell | Tissues Origin

Key People For Maternal Plasma

Top KOLs in the world
#1
Y M Dennis Lo
maternal plasma fetal dna nasopharyngeal carcinoma
#2
Tze Kin Lau
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#3
Tse Ngong Leung
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Christopher W G Redman
normal pregnancy acute atherosis united kingdom
#5
Ian Leonard Sargent
normal pregnancy flow cytometry extracellular vesicles
#6
James S Wainscoat
myelodysplastic syndromes 5q syndrome refractory anemia

Department of Chemical Pathology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong 999077, China. | Department of Chemical Pathology, Li Ka Shing Institute of Health Sciences, Chinese University of Hong Kong, H