Chris Dupont: Influence Statistics

Chris Dupont

Chris Dupont

Wright State University, Department of Neuroscience, Cell Biology, and Physiology, Dayton, United States | Department of Neuroscience, Cell Biology and Physiology, Wright ...

Chris Dupont: Expert Impact

Concepts for which Chris Dupont has direct influence: Myotonia congenita , Transient weakness , Mechanically induced myotonia , Subthreshold currents , Plateau potentials , Underlying transient weakness , Induced myotonia .

Chris Dupont: KOL impact

Concepts related to the work of other authors for which for which Chris Dupont has influence: Electrical myotonia , Transient weakness , Mitochondrial potassium channels , Skeletal muscle fibers , Subthreshold currents , Myotonic dystrophy type , Carbonic anhydrase inhibitors .

KOL Resume for Chris Dupont

Year
2022

Wright State University, Department of Neuroscience, Cell Biology, and Physiology, Dayton, United States

2021

Department of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, United States

2020

Department of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, OH, 45435

2019

Department of Neuroscience, Cell Biology, and Physiology, Wright State University, Dayton, OH

Prominent publications by Chris Dupont

KOL-Index: 7353 . Patients with myotonia congenita suffer from muscle stiffness caused by muscle hyperexcitability. Although loss-of-function mutations in the ClC-1 muscle chloride channel have been known for 25 years to cause myotonia congenita, this discovery has led to little progress on development of therapy. Currently, treatment is primarily focused on reducing hyperexcitability by blocking Na+ ...
Known for Myotonia Congenita | Action Potentials | Muscle Excitability | Potassium Channels
KOL-Index: 3124 . OBJECTIVE: Myotonia is caused by involuntary firing of skeletal muscle action potentials and causes debilitating stiffness. Current treatments are insufficiently efficacious and associated with side effects. Myotonia can be triggered by voluntary movement (electrically induced myotonia) or percussion (mechanically induced myotonia). Whether distinct molecular mechanisms underlie these ...
Known for Myotonia Congenita | Ion Channels | Skeletal Muscle | Genetic Pharmacologic
KOL-Index: 1777 . It is generally thought that muscle excitability is almost exclusively controlled by currents responsible for generation of action potentials. We propose that smaller ion channel currents that contribute to setting the resting potential and to subthreshold fluctuations in membrane potential can also modulate excitability in important ways. These channels open at voltages more negative than ...
Known for Action Potential | Neuromuscular Junction | Ion Channels | Muscle Excitability
KOL-Index: 1620 . Excitation-contraction coupling (ECC) is the process by which electrical excitation of muscle is converted into force generation. Depolarization of skeletal muscle resting potential contributes to failure of ECC in diseases such as periodic paralysis, intensive care unit acquired weakness and possibly fatigue of muscle during vigorous exercise. When extracellular K+ is raised to depolarize ...
Known for Action Potential | Muscle Skeletal | Extracellular Raised
KOL-Index: 277 . In addition to the hallmark muscle stiffness, patients with recessive myotonia congenita (Becker disease) experience debilitating bouts of transient weakness that remain poorly understood despite years of study. We performed intracellular recordings from muscle of both genetic and pharmacologic mouse models of Becker disease to identify the mechanism underlying transient weakness. Our ...

Key People For Myotonia Congenita

Top KOLs in the world
#1
Frank Lehmann‐Horn
malignant hyperthermia skeletal muscle paramyotonia congenita
#2
Kenneth W Ricker
paramyotonia congenita myotonic dystrophy type myasthenia gravis
#3
Alfred L George
sodium channel paramyotonia congenita skeletal muscle
#4
Manuela C Koch
myotonic dystrophy myotonia congenita genetic counseling
#5
Thomas J Jentsch
chloride channels potassium channel xenopus oocytes
#6
Klaus Steinmeyer
chloride channel xenopus oocytes cell cycle

Wright State University, Department of Neuroscience, Cell Biology, and Physiology, Dayton, United States | Department of Neuroscience, Cell Biology and Physiology, Wright State University, Dayton, United States | Department of Neuroscience, Cell Biol