Publicaciones recientes sobre Tumor Dipg

Palliative Re-Irradiation For Progressive Diffuse Intrinsic Pontine Glioma (Dipg)...

[ CLINICAL_TRIAL ] ... to tumor bed. Radiation will be done in standard accelerators and according to standard guidelines used in treatment for all brain tumor patients.. Although DIPG is not curab
Known for
Diffuse Intrinsic | Pontine Glioma | Irradiation Progressive | Dipg Curable

Ezh2i Epz-6438 And Hdaci Vorinostat Synergize With Onc201/tic10 To Activate...

[ PUBLICATION ] ... demonstrated tumor regressions and disease stability in patients with histone H3K27M-mutated midline-glioma. H3K27M-mutation prevents H3K27-methylation on the mutated allele. EZH2 ...
Known for
H3k27 Methylation | Integrated Stress Response | Ezh2i Epz-6438 | Hdaci Vorinostat

Dipg In Children – What Can We Learn From The Past?

[ PUBLICATION ] ... (DIPG) is the most common brainstem tumor of childhood. DIPG is almost uniformly fatal and is the leading cause of brain tumor-related death in children. To date, radiation therapy (RT) is ...
Known for
Targeted Therapies | Tumor Dipg | Pediatric Hgg | Adjuvant Chemotherapy

Repurposing Vandetanib Plus Everolimus For The Treatment Of Acvr1-Mutant Diffuse...

[ PUBLICATION ] ... (DIPG), but there are no ACVR1 inhibitors licensed for the disease. Using an artificial intelligence-based platform to search for approved compounds for ACVR1-mutant DIPG, the combination ...
Known for
Repurposing Vandetanib | Diffuse Intrinsic Pontine Glioma | Dipg Acvr1 | Artificial Intelligence

Correlation Of 18f-Fdg Pet And Mri Apparent Diffusion Coefficient Histogram...

[ PUBLICATION ] ... (DIPG) and to correlate these metrics with baseline MRI apparent diffusion coefficient (ADC) histogram metrics, progression-free survival (PFS), and overall survival. Methods: Baseline ...
Known for
18f-Fdg Pet | Histogram Metrics | Hazard Ratio | Favorable Pfs

Therapeutic Reversal Of Prenatal Pontine Id1 Signaling In Dipg

[ PUBLICATION ] ... (DIPG) is a highly aggressive brain tumor with rare survival beyond two years. This poor prognosis is largely due to the tumor’s highly infiltrative and invasive nature. Previous reports ...
Known for
Tumor Cells | Prenatal Pontine Id1 | Therapeutic Reversal | Transcription Factor

Senescence Induced By Bmi1 Inhibition Is A Therapeutic Vulnerability In...

[ PUBLICATION ] ... (DIPG) is an incurable brain tumor of childhood characterized by histone mutations at lysine 27, which results in epigenomic dysregulation. There has been a failure to develop effective ...
Known for
Bmi1 Inhibition | H3k27m-Mutant Dipg | Therapeutic Vulnerability | Epigenomic Regulators

A Pilot Radiogenomic Study Of Dipg Reveals Distinct Subgroups With Unique...

[ PUBLICATION ] ... (DIPG) is essential, especially in the absence of universal biopsy, to further characterize the molecular heterogeneity of this disease and determine which patients are most likely to ...
Known for
Therapeutic Targets | Distinct Subgroups | Unique Trajectories | Response Dipg

Increased 5-Hydroxymethylcytosine And Decreased 5-Methylcytosine Are Indicators...

[ PUBLICATION ] ... (DIPG) is a malignant pediatric brain tumor associated with dismal outcome. Recent high-throughput molecular studies have shown a high frequency of mutations in histone-encoding genes ...
Known for
Epigenetic Dysregulation | Pediatric Gbm | Normal Brain | Intrinsic Pontine Glioma

Ctim-08. Safety, Efficacy, And Survival Results From A Phase 1 Study Of The...

[ PUBLICATION ] ... (DIPG) is the most lethal pediatric brain tumor. Median overall survival (OS) with standard of care radiation therapy (RT) is approximately 8-10 months and 2-year survival is < 10%. A ...
Known for
Oncolytic Adenovirus | Commonly Reported | Intratumoral Injection | Drug Relationship

 

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