Young Whan Kim

BACKGROUND: A hallmark of idiopathic pulmonary fibrosis is the excess accumulation of extracellular matrix in the lungs. Degradation of extracellular matrix generates free-circulating protein fragments called neoepitopes. The aim of the INMARK trial was to investigate changes in neoepitopes as predictors of disease progression in patients with idiopathic pulmonary fibrosis and the effect of nintedanib on these biomarkers.

METHODS: In this randomised, double-blind, placebo-controlled ...

Background: It has been suggested that a high-flow nasal cannula (HFNC) could help to remove carbon dioxide (CO2) from anatomical dead spaces, but evidence to support that is lacking. The objective of this study was to elucidate whether use of an HFNC could reduce the arterial partial pressure of CO2 (PaCO2) in patients with acute hypercapnic respiratory failure who are receiving conventional oxygen (O2) therapy.

Methods: A propensity score-matched observational study was conducted to ...

Diffuse panbronchiolitis (DPB), which is prevalent in Japan, is known to be rare outside Japan. Although a case of diffuse panbronchiolitis in a second generation Korean was reported in Japan in 1986, no case has been reported in Korea. Recently we found 5 cases of diffuse panbronchiolitis in Korea, two histologically proven and three clinically and radiologically suspected. All 5 cases had the typical respiratory symptoms and signs and a history of chronic sinusitis. In three clinically ...

Rationale: In recent decades, diagnosis and treatment recommendations for idiopathic pulmonary fibrosis (IPF) have changed. In Korea, the average life expectancy has increased, unmet healthcare needs have been reduced, and the number of computed tomographic examinations performed has nearly doubled. The Korean Interstitial Lung Disease Study Group conducted a nationwide cohort study for idiopathic interstitial pneumonia, including IPF, and established a registry for IPF.Objectives: Using ...

Indoor VOC and aldehydes may increase oxidative stress for home dwellers. Our study aim was to determine the correlations between oxidative stress markers in subjects and exposure to VOC and aldehydes in homes. Among ninety five control subjects in Ansan and Incheon (South Korea), blood samples were collected for evaluation of total antioxidant capacity, malondialdehyde (MDA) in plasma, protein carbonyl, and DNA damage of lymphocytes. Indoor VOC and aldehydes were measured in the homes ...

This paper discusses a knowledge based information retrieval model with hierarchical thesaurus. The model computes the conceptual distance between a query and an object and both are indexed with weighted terms from a hierarchical thesaurus. The hierarchical thesaurus is represented by a hierarchical‐concept graph (HCG) in which nodes represent concepts and directed edges represent generalisation relationships. Rada et al . have developed a similar model. However, their model considered ...

BACKGROUND: Smoking has been considered an important risk factor for idiopathic pulmonary fibrosis (IPF) incidence. However, there are no population-based large-scale studies demonstrating the effects of smoking on the development of IPF. We aimed to evaluate the effect of smoking on IPF development using a nationwide population-based cohort.

METHODS: Using the Korean National Health Information Database, we enrolled individuals who had participated in the health check-up service between ...

Survival times of 219 patients diagnosed with multidrug-resistant tuberculosis were calculated and treatment outcomes compared. Mean survival of 20 patients who failed to be cured was 109.8 months (95% confidence interval [CI], 87.4-132.1), shorter than that of 150 patients who were cured (140.4 months; 95% CI, 136.1-144.7; P < .01) and that of 28 patients classified as treatment completed (138.5 months; 95% CI, 131.0-146.1; P = .02). The results demonstrate that patients with ...

BACKGROUND: Low-dose tacrolimus-based immunosuppression is a standard therapy in kidney and liver transplantation; however, the optimal therapeutic level of tacrolimus has not been established in lung transplantation. We aimed to identify the tacrolimus level associated with better outcomes in lung transplant patients.

METHODS: This retrospective study included patients who underwent lung transplantation at Seoul National University Hospital between 2006 and 2016. Kaplan-Meier survival ...

BACKGROUND: Desaturation is a common complication of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA). Dexmedetomidine (DEX), a commonly used sedative in intensive care, is associated with less respiratory depression compared with other sedatives.

OBJECTIVE: We compared DEX with midazolam (MDZ) when used as a sedative during EBUS-TBNA.

DESIGN: A randomised, parallel, double-blinded trial.

SETTING: A university-affiliated teaching hospital between June 2014 and ...