Paul James Brindley: Influence Statistics

Paul James Brindley

Paul James Brindley

Department of Microbiology, Immunology and Tropical Medicine, and Research Center for Neglected Diseases of Poverty, George Washington University, Washington, DC, United ...

Paul James Brindley: Expert Impact

Concepts for which Paul James Brindley has direct influence: Schistosoma mansoni , Schistosoma japonicum , Opisthorchis viverrini , Liver fluke , Schistosoma haematobium , Carcinogenic liver fluke , Nematospiroides dubius .

Paul James Brindley: KOL impact

Concepts related to the work of other authors for which for which Paul James Brindley has influence: Schistosoma mansoni , Opisthorchis viverrini , Clonorchis sinensis , Fasciola hepatica , Liver fluke , Helminth infections , Gene expression .

KOL Resume for Paul James Brindley

Year
2022

Department of Microbiology, Immunology and Tropical Medicine, and Research Center for Neglected Diseases of Poverty, George Washington University, Washington, DC, United States

2021

Department of Microbiology, Immunology & Tropical Medicine, and Research Center for Neglected Diseases of Poverty, School of Medicine and Health Sciences, The George Washington University, Washington, DC, United States

Research Center for Neglected Diseases of Poverty, School of Medicine & Health Sciences, George Washington University, Washington, DC 20037, USA

2020

Department of Microbiology, Immunology & Tropical Medicine, and Research Center for Neglected Diseases of Poverty, School of Medicine and Health Sciences, George Washington University, 20052, Washington, DC, USA

2019

Department of Microbiology, Immunology and Tropical Medicine, George Washington University, Washington, DC, United States of America

Research Center for Neglected Diseases of Poverty, School of Medicine Health Sciences, George Washington University, Washington DC, United States

2018

Department of Microbiology, Immunology & Tropical Medicine, and Research Center for Neglected Diseases of Poverty, School of Medicine & Health Sciences, George Washington University, 20037, Washington, DC, USA

Research Center for Neglected Diseases of Poverty, School of Medicine and Health Sciences, George Washington University, Washington DC, United States of America

2017

Department of Microbiology, Immunology, and Tropical Medicine, Research Center for Neglected Diseases of Poverty, School of Medicine & Health Sciences, The George Washington University, Washington, DC, USA

Research Center for Neglected Tropical Diseases of Poverty, School of Medicine & Health Sciences, The George Washington University, Washington DC, United States of America

2016

Research Center for Neglected Diseases of Poverty, Department of Microbiology, Immunology and Tropical Medicine, School of Medicine & Health Sciences, George Washington University, Washington, D.C., United States of America

2015

Department of Microbiology, Immunology & Tropical Medicine, and Research Center for the Neglected Diseases of Poverty, School of Medicine & Health Sciences, George Washington University, Washington, DC, United States of America

Research Center for Neglected Diseases of Poverty, School of Medicine and Health Sciences, George Washington University, Washington, DC 20037 USA

Prominent publications by Paul James Brindley

KOL-Index: 14739 . BACKGROUND: Of the major families of long terminal repeat (LTR) retrotransposons, the Pao/BEL family is probably the least well studied. It is becoming apparent that numerous LTR retrotransposons and other mobile genetic elements have colonized the genome of the human blood fluke, Schistosoma mansoni. RESULTS: A proviral form of Sinbad, a new LTR retrotransposon, was identified in the ...
Known for Schistosoma Mansoni | Human Blood Fluke | Pao Elements | Amino Acid
KOL-Index: 13211 . The recent release of draft genome sequences of two of the major human schistosomes has underscored the pressing need to develop functional genomics approaches for these significant pathogens. The sequence information also makes feasible genome-scale investigation of transgene integration into schistosome chromosomes. Retrovirus-mediated transduction offers a means to establish transgenic ...
Known for Schistosoma Mansoni | Reporter Transgenes | Schistosome Chromosomes | Leukemia Virus
KOL-Index: 12778 . BACKGROUND: Schistosomes are trematode parasites of the phylum Platyhelminthes. They are considered the most important of the human helminth parasites in terms of morbidity and mortality. Draft genome sequences are now available for Schistosoma mansoni and Schistosoma japonicum. Non-coding RNA (ncRNA) plays a crucial role in gene expression regulation, cellular function and defense, ...
Known for Schistosoma Japonicum | Helminth Rna | Mansoni Genome | Nucleic Acid
KOL-Index: 11977 . Cysteine proteinases expressed by schistosomes appear to play key roles in the digestion of host hemoglobin, the principal source of amino acid nutrients utilized by these parasites. We have shown previously that the predominant cysteine proteinase activity in soluble extracts and excretory/secretory (ES) products of adults of Schistosoma mansoni and S. japonicum is cathepsin L-like in its ...
Known for Host Hemoglobin | Mansoni Cathepsin | Recombinant Smcl1 | Substrate Specificity
KOL-Index: 11852 . BACKGROUND: The liver fluke Opisthorchis viverrini infects several million people in Southeast Asia. Adult flukes live in the bile ducts of humans, where they cause hepatobiliary pathology, including cholangiocarcinoma. Here, we investigated the potential of extracellular vesicles (EVs) secreted by the fluke and defined recombinant proteins derived from EVs to generate protective immunity ...
Known for Challenge Infection | Extracellular Vesicles | Opisthorchis Viverrini | Adult Flukes
KOL-Index: 11771 . This report presents the deduced amino acid sequence of a novel cathepsin L proteinase from Schistosoma mansoni, and describes cathepsin L-like activity in extracts of adult schistosomes. Using consensus primers specific for cysteine proteinases, gene fragments were amplified from adult S. mansoni cDNA by PCR and cloned. One of these fragments showed marked identity to Sm31, the cathepsin ...
Known for Schistosoma Mansoni | Sequence Cathepsin | Cysteine Proteinases | Proteinase Activity
KOL-Index: 11690 . The genome of Schistosoma mansoni contains a proviral form of a retrovirus-like long terminal repeat (LTR) retrotransposon, designated BOUDICCA: Sequence and structural characterization of the new mobile genetic element, which was found in bacterial artificial chromosomes prepared from S. mansoni genomic DNA, revealed the presence of three putative open reading frames (ORFs) bounded by ...
Known for Schistosoma Mansoni | Sequence Analysis | Terminal Repeat | Boudicca Artificial
KOL-Index: 11594 . BACKGROUND: The liver fluke Opisthorchis viverrini is classified as a class I carcinogen due to the association between cholangiocarcinoma and chronic O. viverrini infection. During its feeding activity within the bile duct, the parasite secretes several cathepsin F cysteine proteases that may induce or contribute to the pathologies associated with hepatobiliary ...
Known for Liver Fluke | Opisthorchis Viverrini | Cysteine Protease | Ov Cf1
KOL-Index: 11296 . More than 750 million people are at risk of infection with foodborne liver flukes. Opisthorchis viverrini is considered among the most important of these parasites, due to its strong association with cholangiocarcinoma (CCA). O. viverrini infection results in a chronic inflammatory challenge to the host, which can lead to advanced, pathogen-specific disease sequelae including obstructive ...
Known for Advanced Periductal Fibrosis | Opisthorchis Viverrini | Elevated Levels | Risk Infection
KOL-Index: 11188 . BACKGROUND: It is becoming apparent that perhaps as much as half of the genome of the human blood fluke Schistosoma mansoni is constituted of mobile genetic element-related sequences. Non-long terminal repeat (LTR) retrotransposons, related to the LINE elements of mammals, comprise much of this repetitive component of the schistosome genome. Of more than 12 recognized clades of non-LTR ...
Known for Schistosoma Mansoni | Rte Clade | Human Blood Fluke | Ltr Retrotransposons
KOL-Index: 11030 . BACKGROUND: Nasopharyngeal carcinoma (NPC) is a solid tumor of the head and neck. Multimodal therapy is highly effective when NPC is detected early. However, due to the location of the tumor and the absence of clinical signs, early detection is difficult, making a biomarker for the early detection of NPC a priority. The dysregulation of small non-coding RNAs (miRNAs) during carcinogenesis ...
Known for Nasopharyngeal Carcinoma Npc | Mirna Profiles | Early Detection | Tumor Carcinoma
KOL-Index: 10639 . The human liver fluke, Opisthorchis viverrini, induces inflammation of the hepatobiliary system. Despite being constantly exposed to inimical oxygen radicals released from inflammatory cells, the parasite survives for many years. The mechanisms by which it avoids oxidative damage are unknown. In this study, thioredoxin peroxidase (TPx), a member of the peroxiredoxin superfamily, was cloned ...
Known for Thioredoxin Peroxidase | Opisthorchis Viverrini | Liver Fluke | Antioxidant Enzyme
KOL-Index: 10547 . The liver fluke Opisthorchis felineus is a member of the triad of epidemiologically relevant species of the trematode family Opisthorchiidae, and the causative agent of opisthorchiasis felinea over an extensive range that spans regions of Eurasia. The International Agency for Research on Cancer classifies the infection with the liver flukes Opisthorchis viverrini and Clonorchis sinensis as ...
Known for Opisthorchis Felineus | Biliary Tract | Liver Fluke | Intraepithelial Neoplasia
KOL-Index: 10484 . We characterized the consensus sequence and structure of a long terminal repeat (LTR) retrotransposon from the genome of the human blood fluke, Schistosoma japonicum, and have named this element, Gulliver. The full length, consensus Gulliver LTR retrotransposon was 4788 bp, and it was flanked at its 5'- and 3'-ends by LTRs of 259 bp. Each LTR included RNA polymerase II promoter sequences, ...
Known for Schistosoma Japonicum | Ltr Retrotransposon | Sequence Analysis | Terminal Repeat
KOL-Index: 10423 . The human liver fluke, Opisthorchis viverrini, infects millions of people throughout south-east Asia and is a major cause of cholangiocarcinoma, or cancer of the bile ducts. The mechanisms by which chronic infection with O. viverrini results in cholangiocarcinogenesis are multi-factorial, but one such mechanism is the secretion of parasite proteins with mitogenic properties into the bile ...
Known for Host Cells | Growth Factor | Ov Grn1 | Carcinogenic Liver Fluke

Key People For Schistosoma Mansoni

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S RONALD Smithers
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Daniel G Colley
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Department of Microbiology, Immunology and Tropical Medicine, and Research Center for Neglected Diseases of Poverty, George Washington University, Washington, DC, United States | Department of Microbiology, Immunology and Tropical Medicine, School of