Larry J Seidman: Influence Statistics

Larry J Seidman

Larry J Seidman

Department of Psychiatry, Harvard Medical School, Boston, MA, USA | Harvard Medical School at Beth Israel Deaconess Medical Center and Massachusetts General Hospital | ...

Larry J Seidman: Expert Impact

Concepts for which Larry J Seidman has direct influence: Clinical risk , Bipolar disorder , Negative symptoms , Schizotypal personality disorder , Clinical risk psychosis , Affective psychoses , Magnetic resonance .

Larry J Seidman: KOL impact

Concepts related to the work of other authors for which for which Larry J Seidman has influence: Bipolar disorder , Cortical thickness , Patients schizophrenia , Negative symptoms , White matter , Magnetic resonance , Functional connectivity .

KOL Resume for Larry J Seidman

Year
2022

Department of Psychiatry, Harvard Medical School, Boston, MA, USA

Harvard Medical School at Beth Israel Deaconess Medical Center and Massachusetts General Hospital

2021

Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States

Massachusetts General Hospital, Boston

2020

Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center and Massachusetts General Hospital, Boston, Massachusetts, USA

Massachusetts Mental Health Center Public Psychiatry Devision of the Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

2019

From the Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston (Brady, Lee, Seidman, Keshavan); the Schizophrenia and Bipolar Disorders Program, McLean Hospital, Belmont, Mass. (Brady, Öngür); Harvard Medical School, Boston (Brady, Öngür); St. Elizabeth's Medical Center, Boston (Gonsalvez); the Department of Neurology, Ataxia Unit, Cognitive Behavioral Neurology Unit, and Laboratory for Neuroanatomy and Cerebellar Neurobiology, Massachusetts General Hospital and Harvard Medical School, Boston (Schmahmann); the Department of Psychiatry and the School of Social Work, University of Pittsburgh (Eack); and the Berenson-Allen Center for Noninvasive Brain Stimulation and Division for Cognitive Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston (Pascual-Leone, Halko).

Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center and Massachusetts General Hospita, l, Boston, MA, United States

Harvard Medical School (in memoriam)

2018

Department of Psychiatry, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts

Beth Israel Deaconess Medical Center, Harvard Medical School

BIDMC

Harvard, Boston, MA, United States

Prominent publications by Larry J Seidman

KOL-Index: 16614 . We examined the status of the neural network mediating the default mode of brain function, which typically exhibits greater activation during rest than during task, in patients in the early phase of schizophrenia and in young first-degree relatives of persons with schizophrenia. During functional MRI, patients, relatives, and controls alternated between rest and performance of working ...
Known for Default Network | Patients Relatives | Rest Task | Wm Performance
KOL-Index: 15837 . BACKGROUND: Neuroimaging studies have shown structural alterations in several brain regions in children and adults with attention deficit hyperactivity disorder (ADHD). Through the formation of the international ENIGMA ADHD Working Group, we aimed to address weaknesses of previous imaging studies and meta-analyses, namely inadequate sample size and methodological heterogeneity. We aimed to ...
Known for Brain Volume | Adults Adhd | Attention Deficit | Hyperactivity Disorder
KOL-Index: 14709 . IMPORTANCE: Severe neuropsychiatric conditions, such as schizophrenia, affect distributed neural computations. One candidate system profoundly altered in chronic schizophrenia involves the thalamocortical networks. It is widely acknowledged that schizophrenia is a neurodevelopmental disorder that likely affects the brain before onset of clinical symptoms. However, no investigation has ...
Known for Clinical Risk | Thalamic Dysconnectivity | Schizophrenia Individuals | Conversion Psychosis
KOL-Index: 14508 . Importance: Children at familial high risk of schizophrenia spectrum disorders (FHR-SZ) or bipolar disorder (FHR-BP) exhibit neurocognitive impairments. Large studies of neurocognition in young children at familial high risk at the same age are important to differentiate the pathophysiology and developmental trajectory of these 2 groups. Objective: To characterize neurocognitive functions ...
Known for Bipolar Disorder | Children Fhrsz | Familial Risk | Resilience Study
KOL-Index: 14220 . OBJECTIVES: Impaired social, role, and neurocognitive functioning are preillness characteristics of people who later develop psychosis. In people with schizophrenia, neurocognition and negative symptoms are associated with functional impairment. We examined the relative contributions of neurocognition and symptoms to social and role functioning over time in clinically high-risk (CHR) ...
Known for Negative Symptoms | Social Role | Relationship Neurocognition | Baseline Followup
KOL-Index: 13916 . OBJECTIVE: The association between deficits in executive functioning and functional outcomes was examined among adults with attention deficit hyperactivity disorder (ADHD). METHOD: Subjects were adults who did (N=213) and did not (N=145) meet DSM-IV criteria for ADHD. The authors defined having deficits in executive functioning as having at least two measures of executive functioning with ...
Known for Executive Functioning | Adhd Deficits | Hyperactivity Disorder | Attention Deficit
KOL-Index: 13784 . OBJECTIVE: The effect of antipsychotic medication on neurocognitive function remains controversial, especially since most previous work has compared the effects of novel antipsychotic medications with those of high doses of conventional medications. This study compares the neurocognitive effects of olanzapine and low doses of haloperidol in patients with first-episode psychosis. METHOD: ...
Known for Episode Psychosis | Haloperidol Patients | Effects Treatment | Low Doses
KOL-Index: 13489 . Social cognition, the mental operations that underlie social interactions, is a major construct to investigate in schizophrenia. Impairments in social cognition are present before the onset of psychosis, and even in unaffected first-degree relatives, suggesting that social cognition may be a trait marker of the illness. In a large cohort of individuals at clinical high risk for psychosis ...
Known for Social Perception | Emotion Recognition | Theory Mind | Chr Psychosis
KOL-Index: 13415 . Importance: Neurophysiologic measures of early auditory information processing (EAP) are used as endophenotypes in genomic studies and biomarkers in clinical intervention studies. Research in schizophrenia has established correlations among measures of EAP, cognition, clinical symptoms, and functional outcome. Clarifying these associations by determining the pathways through which deficits ...
Known for Negative Symptoms | Functional Outcome | Early Auditory | Cognition Schizophrenia
KOL-Index: 13201 . Importance: Neurocognition is a central characteristic of schizophrenia and other psychotic disorders. Identifying the pattern and severity of neurocognitive functioning during the "near-psychotic," clinical high-risk (CHR) state of psychosis is necessary to develop accurate risk factors for psychosis and more effective and potentially preventive treatments. Objectives: To identify core ...
Known for Transition Psychosis | Psychotic Disorders | Prodrome Longitudinal | Chr Participants
KOL-Index: 13165 . OBJECTIVE: The lack of an accepted standard for measuring cognitive change in schizophrenia has been a major obstacle to regulatory approval of cognition-enhancing treatments. A primary mandate of the National Institute of Mental Health's Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative was to develop a consensus cognitive battery for clinical ...
Known for Cognitive Battery | Matrics Consensus | Mental Health | National Institute
KOL-Index: 12981 . BACKGROUND: Although attention deficit hyperactivity disorder (ADHD) and bipolar disorder (BPD) co-occur frequently and represent a particularly morbid clinical form of both disorders, neuroimaging research addressing this co-morbidity is scarce. Our aim was to evaluate the morphometric magnetic resonance imaging (MRI) underpinnings of the co-morbidity of ADHD with BPD, testing the ...
Known for Adhd Bpd | Bipolar Disorder | Attention Deficit | Mri Study
KOL-Index: 12930 . OBJECTIVE: Studies examining the relationship between maternal smoking during pregnancy and the development of Attention Deficit Hyperactivity Disorder (ADHD) among offspring have yielded mixed results, with some studies suggesting a strong association and others finding no association. These studies have varied in quality of design and measures. The purpose of this study was to evaluate ...
Known for Maternal Smoking | Pregnancy Adhd | Attention Deficit | Hyperactivity Disorder
KOL-Index: 12711 . ADHD is known to have neuropsychological correlates, characterized mainly by executive function (EF) deficits. However, most available data are based on studies of boys through age 12. Our goal was to assess whether girls with ADHD express neuropsychological features similar to those found in boys, and whether these impairments are found in both preteen and teen samples. Participants were ...
Known for Boys Adhd | Executive Functioning | Hyperactivity Disorder | Attention Deficit
KOL-Index: 12705 . BACKGROUND: First-degree relatives of persons with schizophrenia carry elevated genetic risk for the illness and show deficits on high-load information processing tasks. We used functional magnetic resonance imaging (fMRI) to test whether nonpsychotic relatives show altered functional activation in the prefrontal cortex (PFC), thalamus, hippocampus, and anterior cingulate during a working ...
Known for Nonpsychotic Relatives | Magnetic Resonance | Persons Schizophrenia | Anterior Cingulate

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Department of Psychiatry, Harvard Medical School, Boston, MA, USA | Harvard Medical School at Beth Israel Deaconess Medical Center and Massachusetts General Hospital | Massachusetts Mental Health Center Public Psychiatry Division of the Beth Israel D