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  • Larry J Seidman

    Prominent publications by Larry J Seidman

    KOL Index score: 16614

    We examined the status of the neural network mediating the default mode of brain function, which typically exhibits greater activation during rest than during task, in patients in the early phase of schizophrenia and in young first-degree relatives of persons with schizophrenia. During functional MRI, patients, relatives, and controls alternated between rest and performance of working memory (WM) tasks. As expected, controls exhibited task-related suppression of activation in the default ...

    Also Ranks for: Default Network |  patients relatives |  rest task |  wm performance |  mpfc dlpfc
    KOL Index score: 15837

    BACKGROUND: Neuroimaging studies have shown structural alterations in several brain regions in children and adults with attention deficit hyperactivity disorder (ADHD). Through the formation of the international ENIGMA ADHD Working Group, we aimed to address weaknesses of previous imaging studies and meta-analyses, namely inadequate sample size and methodological heterogeneity. We aimed to investigate whether there are structural differences in children and adults with ADHD compared with ...

    Also Ranks for: Brain Volume |  adults adhd |  attention deficit |  hyperactivity disorder |  subcortical structures
    KOL Index score: 14709

    IMPORTANCE: Severe neuropsychiatric conditions, such as schizophrenia, affect distributed neural computations. One candidate system profoundly altered in chronic schizophrenia involves the thalamocortical networks. It is widely acknowledged that schizophrenia is a neurodevelopmental disorder that likely affects the brain before onset of clinical symptoms. However, no investigation has tested whether thalamocortical connectivity is altered in individuals at risk for psychosis or whether ...

    Also Ranks for: Clinical Risk |  thalamic dysconnectivity |  schizophrenia individuals |  conversion psychosis |  fullblown illness
    KOL Index score: 14508

    Importance: Children at familial high risk of schizophrenia spectrum disorders (FHR-SZ) or bipolar disorder (FHR-BP) exhibit neurocognitive impairments. Large studies of neurocognition in young children at familial high risk at the same age are important to differentiate the pathophysiology and developmental trajectory of these 2 groups.

    Objective: To characterize neurocognitive functions in 7-year-old children with FHR-SZ or FHR-BP and a control population.

    Design, Setting, and ...

    Also Ranks for: Bipolar Disorder |  children fhrsz |  familial risk |  resilience study |  dementia tests
    KOL Index score: 14220

    OBJECTIVES: Impaired social, role, and neurocognitive functioning are preillness characteristics of people who later develop psychosis. In people with schizophrenia, neurocognition and negative symptoms are associated with functional impairment. We examined the relative contributions of neurocognition and symptoms to social and role functioning over time in clinically high-risk (CHR) individuals and determined if negative symptoms mediated the influence of cognition on ...

    Also Ranks for: Negative Symptoms |  social role |  relationship neurocognition |  baseline followup |  prodrome longitudinal
    KOL Index score: 13916

    OBJECTIVE: The association between deficits in executive functioning and functional outcomes was examined among adults with attention deficit hyperactivity disorder (ADHD).

    METHOD: Subjects were adults who did (N=213) and did not (N=145) meet DSM-IV criteria for ADHD. The authors defined having deficits in executive functioning as having at least two measures of executive functioning with scores 1.5 standard deviations below those of matched comparison subjects.

    RESULTS: Significantly ...

    Also Ranks for: Executive Functioning |  adhd deficits |  hyperactivity disorder |  attention deficit |  subjects adults
    KOL Index score: 13784

    OBJECTIVE: The effect of antipsychotic medication on neurocognitive function remains controversial, especially since most previous work has compared the effects of novel antipsychotic medications with those of high doses of conventional medications. This study compares the neurocognitive effects of olanzapine and low doses of haloperidol in patients with first-episode psychosis.

    METHOD: Patients with a first episode of schizophrenia, schizoaffective disorder, or schizophreniform disorder ...

    Also Ranks for: Episode Psychosis |  haloperidol patients |  effects treatment |  low doses |  neurocognitive function
    KOL Index score: 13489

    Social cognition, the mental operations that underlie social interactions, is a major construct to investigate in schizophrenia. Impairments in social cognition are present before the onset of psychosis, and even in unaffected first-degree relatives, suggesting that social cognition may be a trait marker of the illness. In a large cohort of individuals at clinical high risk for psychosis (CHR) and healthy controls, three domains of social cognition (theory of mind, facial emotion ...

    Also Ranks for: Social Perception |  emotion recognition |  theory mind |  chr psychosis |  clinical risk
    KOL Index score: 13415

    Importance: Neurophysiologic measures of early auditory information processing (EAP) are used as endophenotypes in genomic studies and biomarkers in clinical intervention studies. Research in schizophrenia has established correlations among measures of EAP, cognition, clinical symptoms, and functional outcome. Clarifying these associations by determining the pathways through which deficits in EAP affect functioning would suggest when and where to therapeutically intervene.

    Objectives: To ...

    Also Ranks for: Negative Symptoms |  functional outcome |  early auditory |  cognition schizophrenia |  deficits eap
    KOL Index score: 13201

    Importance: Neurocognition is a central characteristic of schizophrenia and other psychotic disorders. Identifying the pattern and severity of neurocognitive functioning during the "near-psychotic," clinical high-risk (CHR) state of psychosis is necessary to develop accurate risk factors for psychosis and more effective and potentially preventive treatments.

    Objectives: To identify core neurocognitive dysfunctions associated with the CHR phase, measure the ability of neurocognitive tests ...

    Also Ranks for: Transition Psychosis |  psychotic disorders |  prodrome longitudinal |  chr participants |  neurocognitive tests
    KOL Index score: 13165

    OBJECTIVE: The lack of an accepted standard for measuring cognitive change in schizophrenia has been a major obstacle to regulatory approval of cognition-enhancing treatments. A primary mandate of the National Institute of Mental Health's Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative was to develop a consensus cognitive battery for clinical trials of cognition-enhancing treatments for schizophrenia through a broadly based scientific ...

    Also Ranks for: Cognitive Battery |  matrics consensus |  mental health |  national institute |  test selection
    KOL Index score: 12981

    BACKGROUND: Although attention deficit hyperactivity disorder (ADHD) and bipolar disorder (BPD) co-occur frequently and represent a particularly morbid clinical form of both disorders, neuroimaging research addressing this co-morbidity is scarce. Our aim was to evaluate the morphometric magnetic resonance imaging (MRI) underpinnings of the co-morbidity of ADHD with BPD, testing the hypothesis that subjects with this co-morbidity would have neuroanatomical correlates of both ...

    Also Ranks for: Adhd Bpd |  bipolar disorder |  attention deficit |  mri study |  neuroanatomical correlates
    KOL Index score: 12930

    OBJECTIVE: Studies examining the relationship between maternal smoking during pregnancy and the development of Attention Deficit Hyperactivity Disorder (ADHD) among offspring have yielded mixed results, with some studies suggesting a strong association and others finding no association. These studies have varied in quality of design and measures. The purpose of this study was to evaluate the association between maternal smoking during pregnancy and offspring ADHD, using detailed ...

    Also Ranks for: Maternal Smoking |  pregnancy adhd |  attention deficit |  hyperactivity disorder |  follow studies
    KOL Index score: 12711

    ADHD is known to have neuropsychological correlates, characterized mainly by executive function (EF) deficits. However, most available data are based on studies of boys through age 12. Our goal was to assess whether girls with ADHD express neuropsychological features similar to those found in boys, and whether these impairments are found in both preteen and teen samples. Participants were 101 girls and 103 boys with DSM-III-R ADHD, and 109 comparison girls and 70 boys without ADHD, ages ...

    Also Ranks for: Boys Adhd |  executive functioning |  hyperactivity disorder |  attention deficit |  gender age
    KOL Index score: 12705

    BACKGROUND: First-degree relatives of persons with schizophrenia carry elevated genetic risk for the illness and show deficits on high-load information processing tasks. We used functional magnetic resonance imaging (fMRI) to test whether nonpsychotic relatives show altered functional activation in the prefrontal cortex (PFC), thalamus, hippocampus, and anterior cingulate during a working memory task requiring interference resolution.

    METHODS: Twelve nonpsychotic relatives of persons ...

    Also Ranks for: Nonpsychotic Relatives |  magnetic resonance |  persons schizophrenia |  anterior cingulate |  auditory verbal


    Larry J Seidman: Influence Statistics

    Sample of concepts for which Larry J Seidman is among the top experts in the world.
    Concept World rank
    multi‐atlas brain segmentation #1
    independent apartments homes #1
    childhood premorbid indicators #1
    deficits developmental trajectory #1
    cohort antipsychotic #1
    study referential processing #1
    damcc adhd #1
    female humans mccb #1
    brain activity symptoms #1
    dimensions deficit #1
    mofc anterior posterior #1
    affective psychoses schizophrenia #1
    motorsalience #1
    schools aim #1
    potential biomarkers development #1
    insight firstepisode schizophrenia #1
    feasibility fca #1
    data rci #1
    spd uf #1
    abnormal rsfc dn #1
    psychosis chrs #1
    baseline functioning phase #1
    presence chr #1
    spd subjects cb #1
    risk psychosis study #1
    chr converters #1
    pilot study glucose #1
    attention cohen #1
    damcc activation msit #1
    years prs #1
    spd subjects head #1
    schizophrenia behavior problems #1
    csp female subjects #1
    pcc fhr #1
    psychotic level #1
    families cogs #1
    100 chr subjects #1
    dsrels #1
    performance degree #1
    mind aps #1
    clinical risk syndrome #1
    perseverations independent apartments #1
    dlpfc activity symptoms #1
    language connections #1
    caregivers n14 #1
    chr converters hc #1
    memory enhancement schizophrenia #1
    sample chr #1
    rci regression approaches #1
    spd subjects slices #1

    Key People For Clinical Risk

    Top KOLs in the world
    Thomas >H McGlashan
    personality disorders clinical risk early detection
    Scott >W Woods
    panic disorder clinical risk social cognition
    Tyrone D Cannon
    bipolar disorder clinical risk social cognition
    Diana O Perkins
    clinical risk social cognition negative symptoms
    Larry J Seidman
    clinical risk bipolar disorder negative symptoms
    Alison Ruth Yung
    young people psychotic disorders transition psychosis

    Larry J Seidman:Expert Impact

    Concepts for whichLarry J Seidmanhas direct influence:Clinical risk,  Bipolar disorder,  Negative symptoms,  Schizotypal personality disorder,  Clinical risk psychosis,  Affective psychoses,  Magnetic resonance,  Psychotic disorders.

    Larry J Seidman:KOL impact

    Concepts related to the work of other authors for whichfor which Larry J Seidman has influence:Bipolar disorder,  Cortical thickness,  Patients schizophrenia,  Negative symptoms,  White matter,  Magnetic resonance,  Functional connectivity.



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    Department of Psychiatry, Harvard Medical School, Boston, MA, USA | Harvard Medical School at Beth Israel Deaconess Medical Center and Massachusetts General Hospital | Massachusetts Mental Health Center Public Psychiatry Division of the Beth Israel D