Kunshen Liu

Kunshen Liu

Department Of Cardiology, The First Affiliated Hospital Of Hebei Medical University, Shijiazhuang, Hebei 050031, P.r. China

Direct Impact

Concepts for which Kunshen Liu has direct influence:

endothelin receptor antagonists
pulmonary arterial hypertension
diuretic resistance
renal artery stenosis
inflammatory cardiomyopathy
dehydration-induced water
symptomatic heart

External impact

Concepts related to the work of other authors for which Kunshen Liu has influence:

congestive heart
exercise capacity
renal function
pulmonary arterial hypertension
oral treprostinil
serum uric acid
fontan operation

Prominent publications by Kunshen Liu

KOL-Index: 90 BACKGROUND: Pulmonary arterial hypertension is a devastating disease that leads to right heart failure and premature death. Endothelin receptor antagonists have shown efficacy in the treatment of pulmonary arterial hypertension. OBJECTIVES: To evaluate the efficacy of endothelin receptor antagonists (ERAs) in pulmonary arterial hypertension. SEARCH METHODS: We searched the Cochrane Central ...
Known for
Selective Non-Selective | Hypertension Functional | Antagonists Pulmonary | Moderate Certainty
KOL-Index: 40 Background Arginine vasopressin dependent antidiuresis plays a key role in water-sodium retention in heart failure. In recent years, the role of glucocorticoids in the control of body fluid homeostasis has been extensively investigated. Glucocorticoid deficiency can activate V2R (vasopressin receptor 2), increase aquaporins expression, and result in hyponatremia, all of which can be reversed ...
Known for
32 Rats | Glucocorticoid Receptor Inhibitor Ru486 | Expressions V2r | Furosemide-Sensitive Na-K-2cl Cotransporter
KOL-Index: 30 INTRODUCTION: Newly emerging evidence showed that glucocorticoids could potentiate natriuretic peptides' action by increasing the density of natriuretic peptide receptor A, leading to a potent diuresis and a renal function improvement in patients with acute decompensated heart failure (ADHF). Therefore, glucocorticoid therapy may be used in patients with ADHF. METHODS: One hundred two ...
Known for
Limited Cardiovascular | Glucocorticoids Acute | Scr Baseline
KOL-Index: 26 BACKGROUND: Recent evidence indicates that prednisone can potentiate renal responsiveness to diuretics in heart failure (HF). However, the optimal dose of prednisone is not known. METHOD: Thirty-eight patients with symptomatic HF were randomized to receive standard HF care alone (n = 10) or with low-dose (15 mg/d, n = 8), medium-dose (30 mg/d, n = 10), or high-dose prednisone (60 mg/d, n = ...
Known for
Induced Potent | High-Sensitive C-Reactive Protein | 24-Hour Urinary Output | Thirty-Eight
KOL-Index: 22 In heart failure, the renal responsiveness to exogenous and endogenous atrial natriuretic peptide (ANP) is blunted. The mechanisms of renal hyporesponsiveness to ANP are complex, but one potential mechanism is decreased expression of natriuretic peptide receptor-A (NPR-A) in inner medullary collecting duct (IMCD) cells. Newly emerging evidence shows that glucocorticoids could produce potent ...
Known for
Npr Imcd | Heart Renal | Anp Generation | Newly Emerging
KOL-Index: 20 BACKGROUND: Pulmonary arterial hypertension is a devastating disease, which leads to right heart failure and premature death. Recent evidence suggests that endothelin receptor antagonists may be promising drugs in the treatment of pulmonary arterial hypertension. OBJECTIVES: To evaluate the efficacy of endothelin receptor antagonists in pulmonary arterial hypertension. SEARCH STRATEGY: We ...
Known for
6 Minute Walk Test | Functional Class Deterioration | Antagonists Improve | Cardiopulmonary Haemodynamic Variables
KOL-Index: 17 BACKGROUND: Pulmonary arterial hypertension is a devastating disease, which leads to right heart failure and premature death. Recent evidence suggests that endothelin receptor antagonists may be promising drugs in the treatment of pulmonary arterial hypertension. OBJECTIVES: To evaluate the efficacy of endothelin receptor antagonists in pulmonary arterial hypertension. SEARCH METHODS: We ...
Known for
Idiopathic Pulmonary Hypertension | Functional Class Deterioration | Six-Minute Walk Test | Treated Endothelin
KOL-Index: 15 OBJECTIVE: To determine the safety and efficacy of prednisone in patients with symptomatic heart failure (HF) and hyperuricemia. METHODS: Prednisone therapy was administered for a short time to 191 symptomatic HF patients with hyperuricemia (serum uric acid > 7 mg/dl). RESULTS: Prednisone significantly reduced serum uric acid by 2.99 mg/dl (p < 0.01) and serum creatinine by 0.17 mg/dl (p < ...
Known for
Symptomatic Hf | Acid Serum | Favorable Effects | Prednisone Uric
KOL-Index: 15 Diuretic resistance in heart failure is defined as a state in which diuretic response is diminished or lost before the therapeutic goal of relief from congestion has been reached. Diuretic resistance is very common and is associated with poor outcomes. Over the past decade, several new drugs and devices targeting decongestion and improvement in renal function in patients with heart failure ...
Known for
Glucocorticoid Therapy | Resistance Loop

Department of Cardiology, The First Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei 050031, P.R. China

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