Yoshinori Aragane: Influence Statistics

Yoshinori Aragane

Yoshinori Aragane

Tougenkai Dermatology, Osaka-city, 540-8511 Osaka, Japan. | Tougenkai Dermatology, Osaka, Japan | Department of Pharmacology, Kinki University School of Medicine, Osakasayama, ...

Yoshinori Aragane: Expert Impact

Concepts for which Yoshinori Aragane has direct influence: Solar lentigines , Uv light , Mast cells , Sunburn cells , Contact hypersensitivity , Pyoderma gangrenosum , Melanoma cells .

Yoshinori Aragane: KOL impact

Concepts related to the work of other authors for which for which Yoshinori Aragane has influence: Dna damage , Extracorporeal photopheresis , Cell death , Blue light , Human keratinocytes , Contact hypersensitivity , Ultraviolet radiation .

KOL Resume for Yoshinori Aragane

Year
2022

Tougenkai Dermatology, Osaka-city, 540-8511 Osaka, Japan.

2018

Tougenkai Dermatology, Osaka, Japan

2007

Department of Pharmacology, Kinki University School of Medicine, Osakasayama, Hirakata Ryoikuen, Hirakata, and, International Tougenkai Institute for Phototherapy and Immunotherapy of the Skin, Osaka, Japan

2006

Dermatology Section, International Tougenkai Institute for Immunotherapy and Phototherapy of the Skin, 1-7-18 Itachibori, Nishi-ku, 550-0012, Osaka, Japan

2005

Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University Münster, Münster, Germany; †Department of Dermatology, Kinki University School of Medicine, Osakasayama-City, Osaka, Japan; ‡Therakos, Exton, PA 19341; and §Department of Dermatology, University Kiel, Kiel, Germany

2004

Department of Dermatology, Kinki University School of Medicine, Osakasayama-City, Osaka, Japan

2003

Department of Dermatology, Kinki University School of Medicine, 377–2 Ohnohigashi, Osakasayama‐shi, Osaka 589–8511, Japan

2002

Department of Dermatology, Kinki University School of Medicine, Ohno-Higashi 377-2, Osaka-Sayama city, Osaka 589-8511, Japan

2001

Department of Dermatology, Kinki University School of Medicine, 377-2 Ohnohigashi, Osakasayama-shi, 589-8511, Osaka, Japan

2000

Department of Dermatology,
Kinki University School of Medicine,
Ohno‐Higashi 377–2,
Osaka‐Sayama‐si,
Osaka 589–8511,
Japan

1999

Department of Dermatology, Kinki University School of Medicine, Ohnohigashi, Osaka-sayama, Osaka, Japan

1998

Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University of Münster, D-48149 Münster, Germany

Department of Dermatology, Kinki University School of Medicine, 377‐2 Ohnohigashi, Osakasayama‐shi, Osaka 589, Japan

1997

Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, Department of Dermatology, University Münster, Münster, Germany

1996

Ludwig Boltzmann Institute for Cell Biology and Immunobiology, Department of Dermatology, University Münster, Münster, Germany

1994

DNAX Research Institute of Molecular and Cellular Biology, Inc., Palo Alto, California, U.S.A.

Ludwig Boltzmann Institute of Cellbiology and Immunobiology, Department of Dermatology, University of Muenster, Muenster, Germany

1993

Department of Dermatology and Ludwig Boltzmann Institute for Cell Biology and Immunobiology of the Skin, University Münster, Münster, Germany

Prominent publications by Yoshinori Aragane

KOL-Index: 16022 . Irradiation with ultraviolet (UV) B radiation results in the formation of apoptotic keratinocytes called sunburn cells. Recently, it was demonstrated that keratinocytes can release tumor necrosis factor-alpha (TNF-alpha), which is known to cause apoptosis in particular cells. In addition, it has been shown that UVB light induces the release of TNF-alpha by keratinocytes and that ...
Known for Sunburn Cells | Induced Apoptosis | Tumor Necrosis | Tnfalpha Keratinocytes
KOL-Index: 14461 . Induction of apoptosis in keratinocytes by UV light is a critical event in photocarcinogenesis. Although p53 is of importance in this process, evidence exists that other pathways play a role as well. Therefore, we studied whether the apoptosis-related surface molecule CD95 (Fas/APO-1) is involved. The human keratinocyte cell line HaCaT expresses CD95 and undergoes apoptosis after treatment ...
Known for Uv Light | Direct Activation | Ligand Cd95 | Induces Apoptosis
KOL-Index: 11610 . Epicutaneous application of haptens to UV-exposed skin induces hapten-specific tolerance. This is mediated via regulatory T cells (Tr), as i.v. injection of T cells from UV-tolerized mice into naive animals renders the recipients unresponsive to the respective hapten. However, when UV-induced Tr are injected i.v. into sensitized mice, contact hypersensitivity (CHS) is not suppressed, ...
Known for Contact Hypersensitivity | Effector Phase | Elicitation Chs | Sensitized Mice
KOL-Index: 10499 . Interleukin (IL) 10 is a recently discovered cytokine, originally isolated from T-helper 2 (Th2) cells, which inhibits cytokine production of T-helper 1 (Th1) cells. Because Th1 cells appear to be of importance during the contact hypersensitivity reaction (CHS) we hypothesized that IL-10 might modulate the outcome of CHS in vivo. Intraperitoneal injection of murine recombinant IL-10 (1000 ...
Known for Contact Hypersensitivity | Vivo Effects | Effector Phase | Inbred Balb Mice
KOL-Index: 9761 . Interaction of CD95 ligand with its cognate receptor CD95 induces apoptotic cell death. Alterations in this pathway within tumor cells can result in escape from apoptosis and from immune surveillance. Melanoma cells recently were found to escape an immune attack via high expression of CD95 ligand, thereby inducing apoptosis of activated T lymphocytes. When screening four human melanoma ...
Known for Melanoma Cells | Cd95 Ligand | Apoptotic Cell Death | Immune Attack
KOL-Index: 9518 . The basis of extracorporeal photopheresis is the reinfusion of leukocytes previously exposed to 8-methoxypsoralen (8-MOP) and UVA radiation. It has been approved for the palliative treatment of cutaneous T cell lymphoma and has reported benefits in autoimmune diseases, transplant rejection, and graft-vs-host disease. However, the underlying mechanism of photopheresis remains unresolved. ...
Known for Cells Mice | Specific Regulatory | 8mop Uva | Immune Tolerance
KOL-Index: 9516 . Ultraviolet (UV) light abrogates contact hypersensitivity (CHS) responses and induces hapten-specific tolerance. Because Th-1 cells are critically involved in CHS and are induced to develop by the cytokine interleukin (IL)-12, we asked whether IL-12 might overcome UV-induced local immunosuppression. C3H/HeN mice exposed to low doses of UV light over 4 d and hapten sensitized through the ...
Known for Induced Tolerance | Chs Response | Mice Mice | Il12 Uv
KOL-Index: 9081 . STAT1 is a cytoplasmic transcription factor that is phosphorylated by Janus kinases (Jak) in response to interferon-gamma (IFNgamma). Phosphorylated STAT1 translocates to the nucleus, where it turns on specific sets of IFNgamma-inducible genes. Here, we show that UV light interferes with tyrosine phosphorylation of STAT1, thereby hindering IFNgamma from exerting its biological effects. ...
Known for Uv Light | Janus Kinase | Stat1 Phosphorylation | Gene Activation
KOL-Index: 7711 . It has been shown previously that ultraviolet (UV) light (290-320 nm) activates keratinocytes to release proinflammatory cytokines including interleukin (IL)-6. Because the 5' flanking region of the IL-6 gene contains a consensus NF kappa B binding sequence, the effect of UVB light on an NF kappa B-like binding activity was investigated in a human epidermoid carcinoma cell line (A431). ...
Known for Dna Damage | Nf Kappa | Nuclear Factor | Tumor Cells
KOL-Index: 7522 . BACKGROUND: Despite the increasing incidence of basal cell carcinoma (BCC), its pathogenesis has remained largely unknown. Recently, it was reported that genes involved in tissue morphogenesis, such as sonic hedgehog or patched, were found to be mutated in BCC, suggesting the involvement of those molecules in the pathogenesis of this tumour. Furthermore, there is evidence that the ...
Known for Basal Cell | Wnt Pathway | Beta Catenin | Bcc Pathogenesis
KOL-Index: 7422 . CD95 ligand (CD95L) potently induces apoptosis by activating CD95 on target cells. It has recently been reported that melanoma cells in vivo express a significant amount of CD95L, thereby being immediately able to kill CD95-bearing immunocompetent cells specific for cancer antigens, which infiltrate the lesions. In this study, we employed immunohistochemistry using an antibody directed ...
Known for Cd95 Ligand | Melanoma Cells | Nevus Skin | Membrane Glycoproteins
KOL-Index: 7384 . background. A noncoherent, broadband, intense pulsed light (IPL) source has been used for the symptoms of photoaging skin as a nonablative method. objective. To investigate the efficacy and tolerability of IPL in solar lentigines and ephelides on the face. methods. An open study was performed in patients with solar lentigines and ephelides who received three to five treatments of IPL. ...
Known for Solar Lentigines | 50 Improvement | Intense Pulsed | Light Source

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Tougenkai Dermatology, Osaka-city, 540-8511 Osaka, Japan. | Tougenkai Dermatology, Osaka, Japan | Department of Pharmacology, Kinki University School of Medicine, Osakasayama, Hirakata Ryoikuen, Hirakata, and, International Tougenkai Institute for Ph