• Disease
  • Solar
  • Solar Lentigines
  • Yoshinori Aragane

    Prominent publications by Yoshinori Aragane

    KOL Index score: 16022

    Irradiation with ultraviolet (UV) B radiation results in the formation of apoptotic keratinocytes called sunburn cells. Recently, it was demonstrated that keratinocytes can release tumor necrosis factor-alpha (TNF-alpha), which is known to cause apoptosis in particular cells. In addition, it has been shown that UVB light induces the release of TNF-alpha by keratinocytes and that keratinocytes express the 55-kD receptor for TNF-alpha. Therefore, we investigated whether TNF-alpha is ...

    Also Ranks for: Sunburn Cells |  induced apoptosis |  tumor necrosis |  tnfalpha keratinocytes |  alpha tnf
    KOL Index score: 14461

    Induction of apoptosis in keratinocytes by UV light is a critical event in photocarcinogenesis. Although p53 is of importance in this process, evidence exists that other pathways play a role as well. Therefore, we studied whether the apoptosis-related surface molecule CD95 (Fas/APO-1) is involved. The human keratinocyte cell line HaCaT expresses CD95 and undergoes apoptosis after treatment with UV light or with the ligand of CD95 (CD95L). Incubation with a neutralizing CD95 antibody ...

    Also Ranks for: Uv Light |  direct activation |  ligand cd95 |  induces apoptosis |  recruitment fadd
    KOL Index score: 11610

    Epicutaneous application of haptens to UV-exposed skin induces hapten-specific tolerance. This is mediated via regulatory T cells (Tr), as i.v. injection of T cells from UV-tolerized mice into naive animals renders the recipients unresponsive to the respective hapten. However, when UV-induced Tr are injected i.v. into sensitized mice, contact hypersensitivity (CHS) is not suppressed, suggesting that Tr inhibit the induction, but not the elicitation, of CHS and are inferior to T effector ...

    Also Ranks for: Contact Hypersensitivity |  effector phase |  elicitation chs |  sensitized mice |  induced regulatory
    KOL Index score: 10499

    Interleukin (IL) 10 is a recently discovered cytokine, originally isolated from T-helper 2 (Th2) cells, which inhibits cytokine production of T-helper 1 (Th1) cells. Because Th1 cells appear to be of importance during the contact hypersensitivity reaction (CHS) we hypothesized that IL-10 might modulate the outcome of CHS in vivo. Intraperitoneal injection of murine recombinant IL-10 (1000 ng) into naive mice 24, 72, or 120 h before sensitization by epicutaneous application of ...

    Also Ranks for: Contact Hypersensitivity |  vivo effects |  effector phase |  inbred balb mice |  intraperitoneal injection
    KOL Index score: 9761

    Interaction of CD95 ligand with its cognate receptor CD95 induces apoptotic cell death. Alterations in this pathway within tumor cells can result in escape from apoptosis and from immune surveillance. Melanoma cells recently were found to escape an immune attack via high expression of CD95 ligand, thereby inducing apoptosis of activated T lymphocytes. When screening four human melanoma cell lines for expression of CD95 and CD95 ligand, respectively, an inverse correlation was found, ...

    Also Ranks for: Melanoma Cells |  cd95 ligand |  apoptotic cell death |  immune attack |  receptor apoptosis
    KOL Index score: 9518

    The basis of extracorporeal photopheresis is the reinfusion of leukocytes previously exposed to 8-methoxypsoralen (8-MOP) and UVA radiation. It has been approved for the palliative treatment of cutaneous T cell lymphoma and has reported benefits in autoimmune diseases, transplant rejection, and graft-vs-host disease. However, the underlying mechanism of photopheresis remains unresolved. Because UVB radiation can cause immune tolerance via induction of regulatory T cells, we studied ...

    Also Ranks for: Cells Mice |  specific regulatory |  8mop uva |  immune tolerance |  transplant rejection
    KOL Index score: 9516

    Ultraviolet (UV) light abrogates contact hypersensitivity (CHS) responses and induces hapten-specific tolerance. Because Th-1 cells are critically involved in CHS and are induced to develop by the cytokine interleukin (IL)-12, we asked whether IL-12 might overcome UV-induced local immunosuppression. C3H/HeN mice exposed to low doses of UV light over 4 d and hapten sensitized through the irradiated skin area with dinitrofluorobenzene showed profound inhibition of the CHS response, which ...

    Also Ranks for: Induced Tolerance |  chs response |  mice mice |  il12 uv |  adoptive transfer
    KOL Index score: 9081

    STAT1 is a cytoplasmic transcription factor that is phosphorylated by Janus kinases (Jak) in response to interferon-gamma (IFNgamma). Phosphorylated STAT1 translocates to the nucleus, where it turns on specific sets of IFNgamma-inducible genes. Here, we show that UV light interferes with tyrosine phosphorylation of STAT1, thereby hindering IFNgamma from exerting its biological effects. This effect is not due to a down-regulation of the IFNgamma receptor because phosphorylation of ...

    Also Ranks for: Uv Light |  janus kinase |  stat1 phosphorylation |  gene activation |  biological effects
    KOL Index score: 7711

    It has been shown previously that ultraviolet (UV) light (290-320 nm) activates keratinocytes to release proinflammatory cytokines including interleukin (IL)-6. Because the 5' flanking region of the IL-6 gene contains a consensus NF kappa B binding sequence, the effect of UVB light on an NF kappa B-like binding activity was investigated in a human epidermoid carcinoma cell line (A431). Nuclear factor kappa B (NF kappa B) activation in the cytoplasm is known to be due to the dissociation ...

    Also Ranks for: Dna Damage |  nf kappa |  nuclear factor |  tumor cells |  uv light
    KOL Index score: 7522

    BACKGROUND: Despite the increasing incidence of basal cell carcinoma (BCC), its pathogenesis has remained largely unknown. Recently, it was reported that genes involved in tissue morphogenesis, such as sonic hedgehog or patched, were found to be mutated in BCC, suggesting the involvement of those molecules in the pathogenesis of this tumour. Furthermore, there is evidence that the Wnt-mediated signalling pathway may be one of the downstream targets of sonic hedgehog-mediated signalling, ...

    Also Ranks for: Basal Cell |  wnt pathway |  beta catenin |  bcc pathogenesis |  sonic hedgehog
    KOL Index score: 7422

    CD95 ligand (CD95L) potently induces apoptosis by activating CD95 on target cells. It has recently been reported that melanoma cells in vivo express a significant amount of CD95L, thereby being immediately able to kill CD95-bearing immunocompetent cells specific for cancer antigens, which infiltrate the lesions. In this study, we employed immunohistochemistry using an antibody directed against CD95L to investigate at which stage the melanoma CD95L expression is turned on. Skin biopsies ...

    Also Ranks for: Cd95 Ligand |  melanoma cells |  nevus skin |  membrane glycoproteins |  neoplasms receptor
    KOL Index score: 7384

    background. A noncoherent, broadband, intense pulsed light (IPL) source has been used for the symptoms of photoaging skin as a nonablative method. objective. To investigate the efficacy and tolerability of IPL in solar lentigines and ephelides on the face. methods. An open study was performed in patients with solar lentigines and ephelides who received three to five treatments of IPL. results. Forty-eight percent of patients had more than 50% improvement and 20% had more than 75% ...

    Also Ranks for: Solar Lentigines |  50 improvement |  intense pulsed |  light source |  received treatments


    Yoshinori Aragane: Influence Statistics

    Sample of concepts for which Yoshinori Aragane is among the top experts in the world.
    Concept World rank
    bikunin keratinocytes #1
    rolipram rtpcr #1
    derfinduced il5 mrna #1
    rolipraminduced inhibition #1
    oil benzalkonium #1
    specific bikunin #1
    bikunin human epidermis #1
    bikunin hacat cells #1
    epidermis bikunin #1
    rolipram il4 #1
    itz sensitization #1
    antagonism phosphodiesterase4 inhibitor #1
    ifngamma itz #1
    anti bikunin #1
    immunocompetent cells rolipram #1
    bikunin serine #1
    nuclear translocation rolipram #1
    rolipram mrna #1
    cells derf #1
    granularhorny cell layers #1
    itz chs #1
    antibody bikunin #1
    itraconazole suppresses #1
    performed primers #1
    stimulation derf #1
    bikunin inhibitor #1
    itz elicitation phase #1
    itz contact hypersensitivity #1
    il4induced nuclear translocation #1
    pde4 breakdown #1
    pka inhibitors rolipram #1
    antibikunin antibody #1
    dotted reaction products #1
    bikunin expressed #1
    itz irritant dermatitis #1
    bikunin antibody #1
    chs itz #1
    phospholylated erk1 2 #1
    rolipram human cells #1
    rolipram interference #1
    mrna expression interferongamma #2
    antisepor antibody #2

    Key People For Solar Lentigines

    Top KOLs in the world
    Jean Paul Ortonne
    epidermolysis bullosa atopic dermatitis melanoma cells
    Bert Jan Vermeer
    skin cancer renal transplant recipients solar lentigines
    R Rox Anderson
    photodynamic therapy laser treatment human skin
    Rudi Gerardus Johannes WESTENDORP
    subclinical hypothyroidism cognitive function older people
    Jan Nico Bouwes Bavinck
    skin cancer organ transplant recipients cutaneous warts
    Amit G Pandya
    ruxolitinib cream pemphigus vulgaris treatment melasma

    Yoshinori Aragane:Expert Impact

    Concepts for whichYoshinori Araganehas direct influence:Solar lentigines,  Uv light,  Mast cells,  Sunburn cells,  Contact hypersensitivity,  Pyoderma gangrenosum,  Melanoma cells,  Basal cell.

    Yoshinori Aragane:KOL impact

    Concepts related to the work of other authors for whichfor which Yoshinori Aragane has influence:Dna damage,  Extracorporeal photopheresis,  Cell death,  Blue light,  Human keratinocytes,  Contact hypersensitivity,  Ultraviolet radiation.



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    Tougenkai Dermatology, Osaka-city, 540-8511 Osaka, Japan. | Tougenkai Dermatology, Osaka, Japan | Department of Pharmacology, Kinki University School of Medicine, Osakasayama, Hirakata Ryoikuen, Hirakata, and, International Tougenkai Institute for Ph