Generalized Seizures

[Anny-Palencia-MD]

This article has been medically reviewed by Anny Palencia, MD — 2022-10-19

Who are the top experts researching treatments for generalized seizures?

The top experts researching generalized seizures are: Kenta Sumitomo, Pavel Mares̆ and Tao-Yun Ji.

What are the top concepts researched in studies about generalized seizures?

The most researched concepts in studies of generalized seizures are: Tonic Clonic, Seizure Frequency, Long Term, Status Epilepticus, Temporal Lobe Epilepsy and Antiepileptic Drugs.

What are some of the top places that specialize in generalized seizures?

Recommended institutions that specialize in generalized seizures:

Dr. Jayant N. Acharya, MD 30 Hope Dr #1300, Hershey, PA 17033 Phone: +17175313828

Dr. Mona Sazgar, MD UC Irvine Medical Center, 101 The City Dr S, Orange, CA 92868 Phone: +17144566203

Dr Eli Silber 27 Tooley St, London SE1 2PR, United Kingdom Phone: +442034119888

Tanaka Neurology Clinic 1329-15 Iijimacho, Sakae Ward, Kanagawa 244-0842, Japan Phone: +81458938012

Generalized Seizures

[Anny-Palencia-MD]

This article has been medically reviewed by Anny Palencia, MD — 2022-10-19

#1	Samuel Frank Berkovic
Epilepsy Research Centre, Department of Medicine, The University of Melbourne, Austin Health, Heidelberg, VIC 3084, Australia. | Department of Medicine, Epilepsy Research ... Febrile Seizures | Hippocampal Sclerosis | Generalized Epilepsy | Temporal Lobe | Dravet Syndrome

#2	Solomon L Moshe´
Departments of Neuroscience and Pediatrics, Albert Einstein College of Medicine, Bronx, New York, USA | Isabelle Rapin Division of Child Neurology Saul R. Korey Department of ... Status Epilepticus | Substantia Nigra | Infantile Spasms | Epilepsy Syndromes | Task Force

#3	Robert S Fisher
Department of Neurology, Stanford Neuroscience Health Center, Palo Alto, CA, USA | Department of Neurology and Neurological Sciences, Stanford University School of Medicine, ... Gastric Emptying | Colonic Transit | Botulinum Toxin | Gastroesophageal Junction | Menstrual Cycle

#4	Ingrid Eileen Scheffer
Florey Institute and Murdoch Children's Research Institute, Melbourne, Victoria, Australia | Royal Children's Hospital, University of Melbourne, Melbourne, Victoria, Australia ... Dravet Syndrome | Febrile Seizures | Intellectual Disability | Generalized Epilepsy | Epileptic Encephalopathies

#5	Judith Helen Cross
Developmental Neurosciences Programme, Great Ormond Street Institute of Child Health, University College London, London, UK; Department of Neurology, Great Ormond Street ... Epilepsy Surgery | Dravet Syndrome | Ketogenic Diet | Task Force | Focal Cortical Dysplasia

#6	Gary W Mathern
Department of Psychiatry and Biobehavioral Sciences, Intellectual and Developmental Disabilities Research Center, Semel Institute for Neuroscience and Human Behavior, David ... Cortical Dysplasia | Epilepsy Surgery | Cerebral Hemispherectomy | Cytomegalic Neurons | Rasmussen Encephalitis

#7	Susan Soloway Spencer
Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA | Department of Neurology, Yale School of Medicine, New Haven, CT. | Comprehensive ... Temporal Lobe | Epilepsy Surgery | Seizure Onset | Corpus Callosum | Ictal Spect

#8	Douglas R Nordli
University of Chicago Medicine, Chicago, IL. | Department of Pediatric Neurology, The University of Chicago, Chicago, IL, United States | The University of Chicago, The ... Ketogenic Diet | Febrile Status Epilepticus | Hippocampal Malrotation | Infantile Spasms | Febstat Study

#9	Frederick Andermann
Montreal Neurological Hospital & Institute, McGill University, Montreal, QC, Canada | Epilepsy Research Group, Montreal Neurological Hospital and Institute, Montreal, Quebec, ... Temporal Lobe | Partial Epilepsy | Magnetic Resonance | Surgical Treatment | Hypothalamic Hamartomas

#10	Wolfgang Löscher
Department of Pharmacology, Toxicology and Pharmacy, University of Veterinary Medicine, Hannover, Germany | Center for Systems Neuroscience, Hannover, Germany | Department of ... Kindled Rats | Status Epilepticus | Animal Models | Piriform Cortex | Antiepileptic Drugs

#11	Dan C McIntyre
Department of Neuroscience, Carleton University, Ottawa, Ontario, Canada K1S 5B6 | Institute of Neuroscience, Life Sciences Research Center, Carleton University, Ottawa, ... Amygdala Kindling | Fast Rats | Perirhinal Cortex | Status Epilepticus | Rat Strains

#12	Dennis D Spencer†
From the Comprehensive Epilepsy Center (A.S., L.H., N.G., P.F., H.B.), Department of Neurology, Yale University School of Medicine, New Haven, CT; Service de Neurologie ... Temporal Lobe | Magnetic Resonance | Hippocampal Sclerosis | Epilepsy Surgery | Surgical Outcome

#13	P Gloor
Department of Neurology and Neurosurgery, McGill University and the Montreal Neurological Hospital and Institute, 3801 University Street, H3A 2B4, Montreal, Quebec, Canada | ... Delta Waves | Generalized Penicillin Epilepsy | Temporal Lobe | Epileptic Bursts | Subcortical Structures

#14	Tracy A Glauser
Division of Neurology, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA | Division of Pediatric Neurology, Cincinnati Children's ... Status Epilepticus | Valproic Acid | Initial Monotherapy | Centrotemporal Spikes | Infantile Spasms

#15	Orlando Carter Carter Snead
From the Program in Neuroscience and Mental Health (O.N.A., D.J.M., J.M.Y., S.M.W., M.L.S., G.M.I.), Hospital for Sick Children Research Institute; Institute of Medical ... Infantile Spasms | Absence Seizures | Epilepsy Surgery | Status Epilepticus | Cortical Dysplasia

#16	Michael R Sperling
Department of Neurology and Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, USA | Thomas Jefferson University, Philadelphia, Pennsylvania, USA | Department ... Epilepsy Surgery | Temporal Lobe | Diazepam Nasal Spray | Seizure Outcome | Status Epilepticus

#17	Jeffrey R Buchhalter
University of Calgary, AB, Canada. | Department of Pediatrics, University of Calgary, Calgary, AB, Canada | Alberta Children’s Hospital Research Institute, University of ... Ketogenic Diet | Intravenous Immunoglobulin | Epilepsy Surgery | Sudden Unexpected Death | Ischemic Encephalopathy

#18	Walter van Emde Boas
Department of Clinical Neurophysiology, Stichting Epilepsie Instellingen Nederland (SEIN), The Netherlands | Department of Clinical Neurophysiology, SEIN — Epilepsy Institute ... Presurgical Evaluation | Epileptic Seizures | International Bureau | Temporal Lobe Epilepsy | Sleep Eeg

#19	Christian Marescaux†
EA3072, Université de Strasbourg, Fédération de Médecine Translationnelle de Strasbourg, Unité Neuro-Vasculaire, Service de Neurologie, Service de Neuroradiologie ... Absence Epilepsy | Audiogenic Seizures | Wistar Rats | Neuronal Damage | Sodium Valproate

#20	Perrine Plouin
Department of Clinical Neurophysiology, Hospital Necker Enfant Malades, Paris, France | Clinical Neurophysiology, Necker Hospital, Paris, France. | Clinical Neurophysiology ... Infantile Spasms | West Syndrome | Neonatal Seizures | Cdkl5 Mutations | Respiratory Pauses

[Anny-Palencia-MD]

This article has been medically reviewed by Anny Palencia, MD — 2022-10-19

Selective Frontal, Parietal, And Temporal Networks In Generalized Seizures

.. of generalized seizures widespread regions of the nervous system engage in abnormally synchronous and high-frequency neuronal firing. However, emerging evidence suggests that all neurons ...

Generalized Seizures | Tonic Clonic | Brain Regions | Specific Networks | Focal Onset

Callosotomy For Severe Epilepsies With Generalized Seizures: Outcome And...

.. on generalized seizures, to check the effect on other seizure types and to search for possible prognostic factors.Twenty patients with a minimum follow-up of one year (mean 3.5 years) were ...

Generalized Seizures | Seizure Types | 15 Patients | Corpus Callosum | Minimum Followup

Focal Network Involvement In Generalized Seizures: New Insights From...

Generalized seizures are commonly thought to involve the entire brain homogeneously. However, recent evidence suggests that selective cortical-subcortical networks may be crucial for the ...

Generalized Seizures | Electroconvulsive Therapy | Brain Regions | Unilateral Ect | Computed Tomography

Epileptiform Eeg Activities Of The Centromedian Thalamic Nuclei In Patients With...

.. and generalized seizures through implanted recording-stimulating electrodes, used for seizure control. CM epileptiform activities showed either little or no correlation to focal surface ...

Generalized Seizures | Centromedian Thalamic Nuclei | Eeg Activities | Partial Motor | Seizure Control

Neuromodulation Of The Centromedian Thalamic Nuclei In The Treatment Of...

.. of generalized seizures of the Lennox-Gastaut syndrome (LGS) and improvement of patient disability.

METHODS: Thirteen patients with LGS were studied. They had severe generalized ...

Generalized Seizures | Lennox–gastaut Syndrome | Centromedian Thalamic | Electrical Stimulation | Seizure Reduction

Secondarily Generalized Seizures In Mesial Temporal Epilepsy: Clinical...

.. Secondarily generalized seizures (SGSs) are often considered to be stereotyped, presumably sharing a common electrical pathway. We examined whether SGSs are uniform in a homogeneous group ...

Generalized Seizures | Lateralizing Signs | Mesial Temporal | Electroencephalography Epilepsy | Clonic Activity

Preferential Blood Flow To Brainstem During Generalized Seizures In The Newborn...

.. of generalized seizures on local cerebral blood flow was studied autoradiographically in 21 immature marmoset monkeys, using either [123I]- or [131I]isopropyliodoamphetamine. Generalized ...

Blood Flow | Generalized Seizures | Cerebral Cortex | Newborn Marmoset Monkey | Brain Regions

Lamotrigine For Generalized Seizures Associated With The Lennox–gastaut Syndrome

BACKGROUND: The Lennox-Gastaut syndrome, a severe form of epilepsy that usually begins in early childhood, is difficult to treat. Dose-related drug toxicity is common.

METHODS: We conducted a ...

Generalized Seizures | Lamotrigine Placebo | Lennoxgastaut Syndrome | 16 Weeks | Early Childhood

Regionally Selective Stimulation Of Mitogen Activated Protein (Map) Kinase...

.. that generalized seizures stimulate tyrosine phos

Tyrosine Phosphorylation | Rat Brain | Generalized Seizures | Mitogen Activated Protein | Map Kinase

Cav2.1 Ablation In Cortical Interneurons Selectively Impairs Fast‐spiking Basket...

OBJECTIVE: Both the neuronal populations and mechanisms responsible for generalized spike-wave absence seizures are poorly understood. In mutant mice carrying loss-of-function (LOF) mutations ...

Cortical Interneurons | Generalized Seizures | Gaba Release | Immunohistochemical Assays | Mutant Mice

Gabapentin In Generalized Seizures

.. in generalized seizures was evaluated in this 14 week, double-blind, placebo-controlled, parallel-group, add-on, multicenter study. A total of 129 patients with refractory generalized ...

Generalized Seizures | Antiepileptic Drugs | Greater Reduction | Addon Therapy | Efficacy Gabapentin

Repeated Stimulation Of Dopamine D1‐like Receptor And Hyperactivation Of Mtor...

The acute activation of the dopamine D1-like receptors (D1R) is involved in a plethora of functions ranging from increased locomotor activity to the facilitation of consolidation, storage, and ...

Generalized Seizures | Dopamine D1 | Memory Deficits | Dentate Gyrus | Mtor Signaling

Galanin Expressed In The Excitatory Fibers Attenuates Synaptic Strength And...

The neuropeptide galanin is considered to be an endogenous antiepileptic agent, presumably acting via inhibition of glutamate release. Previously, we have demonstrated that in mice ectopically ...

Piriform Cortex | Generalized Seizures | Excitatory Synapses | Mossy Fibers | Neuropeptide Galanin

Repeated Generalized Seizures Induce Time-Dependent Changes In The Behavioral...

This study examined both the acute and long-lasting changes in seizure susceptibility that occur in response to the repeated induction of generalized seizure activity. Daily flurothyl-induced ...

Generalized Seizure | Animal Epilepsy | Repeated Induction | Progressive Increase | Stimulation Free

Enhanced Synchrony In Epileptiform Activity? Local Versus Distant Phase...

.. of generalized seizures. However, a few recent reports have described substantial fluctuations in synchrony before and during ictal events, thus raising questions as to the widespread ...

Generalized Seizures | Epileptiform Activity | Phase Synchronization | Absence Female Humans | Complex Systems

Efficacy Of The Ketogenic Diet In Focal Versus Generalized Seizures

.. for generalized seizures. Few data are available regarding its effect on focal seizures. We retrospectively studied patients (mean = 7.5 years of age) with medically intractable epilepsy ...

Ketogenic Diet | Generalized Seizures | 6 Months | Patients Focal | Seizure Reduction

A Unifying Explanation Of Primary Generalized Seizures Through Nonlinear Brain...

The aim of this paper is to explain critical features of the human primary generalized epilepsies by investigating the dynamical bifurcations of a nonlinear model of the brain's mean field ...

Generalized Seizures | Bifurcation Analysis | Nonlinear Brain | Electrical Activity | Model Dynamics

Epileptiform Eeg Activity Of The Centromedian Thalamic Nuclei In Children With...

.. intractable generalized seizures of Lennox-Gastaut syndrome (LGS) through implanted recording-stimulating electrodes used for seizure control. Ictal CM epileptiform activities were ...

Centromedian Thalamic Nuclei | Generalized Seizures | Lennox‐gastaut Syndrome | Preschool Electrodes | Spike Wave

The Role Of Technical, Biological, And Pharmacological Factors In The Laboratory...

.. of generalized seizures, i.e. th

Anticonvulsant Drugs | Generalized Seizures | Laboratory Conditions | Activity Phenobarbital | Carbamazepine Valproate

Postictal Generalized Electroencephalographic Suppression Is Associated With...

Postictal generalized electroencephalographic suppression (PGES) may be involved in sudden unexpected death in epilepsy (SUDEP). We examined whether the occurrence of PGES depends on seizure ...

Generalized Seizures | Epilepsy Sudep | Seizure Type | Sudden Electroencephalography | Eeg Recordings