Static Encephalopathy

Static Encephalopathy

Static encephalopathy is a type of encephalopathy (a brain disorder) that is chronic but non-progressive in nature.

In other words, it is a type of brain dysfunctioning that is relatively constant and does not change over a period of time.

This article has been medically reviewed by Marither Oropeza, MD — 2022-10-6

Static Encephalopathy significantly affects the motor functions and mechanisms that impact postures. Mental alterations caused due to static encephalopathy might result in a number of issues related to cognitive development. Static encephalopathy could be prevented by early treatment with focus on the primary causes that triggered the condition.

Static Encephalopathy Symptoms

The following are the symptoms of static encephalopathy:

1. Loss of memory and deterred consciousness.

2. Speech impairment and change in personality.

3. Depression, anxiety and decline in activity.

4. Apart from the cognitive symptoms, other symptoms that might be caused due to a more complex encephalopathy include seizures, abnormal breathing, coma and involuntary movements.

Encephalopathy: Key Players in Social Media

The most prominent accounts for the topic of encephalopathy are: NFLCFacts (active voice for retired NFL players), PharmaFactz, Elliot Tapper and Mark Oldham.

Types of encephalopathy

There are a number of causes which results in the development of static encephalopathy. The causes can range from environmental to genetics [1], and depending on the type of factor that triggered the condition, the types of static encephalopathy can be classified inas follows:

Metabolic Encephalopathy

Metabolic encephalopathy is a change in brain consciousness as a result of diffusion or global dysfunction of the brain caused due to compromised cerebral metabolism. In other words, a broad category of encephalopathy that covers the effect of changes in the metabolic activities on the brain functions is known as metabolic encephalopathy.

Discrepancies in the levels of vitamins, water, electrolytes and other chemicals in the body which might be a result of disordered metabolic processes could have adverse effects on the functioning of the brain. Continuous supply of oxygen, glucose and other nutrients to neurons through circulation plays a significant role in the metabolic functions of the brain and therefore an imbalance in their concentration could affect the brain activity thereby causing encephalopathy.

Acute Metabolic Encephalopathy

Acute metabolic encephalopathy is a type of metabolic encephalopathy as mentioned above that develops acutely and causes drowsiness with agitation that alters arousal when a metabolic disturbance occurs. Acute metabolic abnormalities in the blood sugar levels, vitamin levels, unwanted concentration of liver and kidney wastes, thyroid issues could also have an indirect impact on the process of brain functioning. However, the occurrence of acute metabolic encephalopathy is dependent on a number of factors that are responsible for changing blood flow, failure of the metabolism process related to energy and depolarization at cell levels [2].

Acute metabolic encephalopathies have shown a reversible potential given the underlying metabolic disorder is managed. However, if the abnormalities caused due to acute metabolic encephalopathies are not treated within a certain period of time then it may cause secondary damage to the brain structure that may in turn result in chronic encephalopathies.

Toxic Encephalopathy

Toxic encephalopathy is a type of encephalopathy triggered by brain function damage due to exposure to toxic materials. Generally, there is a significant relationship between the type of toxic exposure and the onset of symptoms and therefore the symptoms are immediately visible after acute exposure whereas a little delay in onset is observed when there is a chronic exposure of toxic substances.

Neurotoxins like organic solvents, heavy metals and other chemicals have the potential to cause a decline in the brain reserves thereby creating more vulnerability in the brain cells with respect to aging.

Acute toxic encephalopathy may occur due to exposure to organic solvents that have the potential to penetrate into the cell membrane whereas exposure to certain gasses like cyanide, carbon monoxide, anesthetics and hydrogen sulfide can diffuse and affect functions of the brain, whereas chronic toxic encephalopathy is caused through long-term exposure of toxins that causes continuous diffusion injury to the brain.

Epileptic Encephalopathy

Epileptic Encephalopathy is marked by a A decline in the neurological function caused due to epileptic activities like severe seizures or interictal activity at sub continuous paroxysmal.

Seizures are caused due to a sudden electrical activity in the brain and can have a significant impact on the motility, behavior and consciousness of an individual. The prevalence of epileptic encephalopathy is mostly observed during the early childhood years and is dependent on the functional and structural growth of the brain. Since seizures do not follow a particular pattern and high level of randomness, the recognition as well as management of epileptic encephalopathy becomes quite significant. Cerebral malformation could also be an underlying reason for seizures that can in turn onset epileptic encephalopathy that could help in treating seizures through neurosurgery in certain cases.

Static Encephalopathy Diagnosis and Treatment

A general brain test and the observation of symptoms by a medical expert could be used to diagnose static encephalopathy. Imaging techniques like an MRI or CT scans could be used to find the location and magnitude of the brain issues. Electroencephalography (EEG) test could also be used to diagnose encephalopathy as it is responsible for measuring the brain’s electrical activity. Spinal fluids, blood or urine tests could also be used for diagnosis.

Medications to stop seizures could be used to treat epileptic encephalopathy whereas dialysis could be used to treat metabolic encephalopathy. Improving the quality of life through consuming nutritional supplements and exercising on a regular basis could also be used to manage metabolic and toxic encephalopathy.


Static Encephalopathy - References

  1. ^ Noboru N Mizushima, et. al. (2013). De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood. Retrieved 29 Oct 2022.
  2. ^ Jain P., et. al. (2013). Diagnosis and Management of Epileptic Encephalopathies in Children. Epilepsy Research and Treatment, 501981. https://doi.org/10.1155%2F2013%2F501981. Retrieved 29 Oct 2022.
  3. ^ Surtis R. and Leonard J. (1989). Acute metabolic encephalopathy: a review of causes, mechanisms and treatment. Journal of Inherited Metabolic Disease, 1:42-54. https://doi.org/10.1007/bf01799285 . Retrieved 30 Oct 2022.
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This article has been medically reviewed by Marither Oropeza, MD — 2022-10-6

Who are the top experts researching treatments for static encephalopathy?

The top experts researching static encephalopathy are: Hirotomo Saitsu, Susan A. Rethlefsen and Mary L. Zupanc.

Static Encephalopathy

What are the top concepts researched in studies about static encephalopathy?

The most researched concepts in studies of static encephalopathy are: Cerebral Palsy, Mental Retardation, Basal Ganglia, Fetal Alcohol, Brain Iron Accumulation, Childhood Neurodegeneration, Movement Disorders, Intellectual Disability, Magnetic Resonance and Novo Mutations.



What are some of the top places that specialize in static encephalopathy?

Recommended institutions that specialize in static encephalopathy:

Mind Health Institute, Pasadena 200 E Del Mar Blvd Suite 200, Pasadena, CA 91105 Phone: +16267233099

Mindful Care Psychiatry 510 Hempstead Turnpike #203, West Hempstead, NY 11552 Phone: +15165594041

The Blue Tree Clinic The Coach House, The Blue Tree Clinic The Blue Tree Clinic, 39 College Cres, London NW3 5LB, United Kingdom Phone: +447729528568

Harai Clinic Japan, 〒104-0031 Tokyo, Chuo City, Kyobashi, 2 Chome−6−6 藤木ビル 2階 Phone: +81335386055

Static Encephalopathy

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This article has been medically reviewed by Marither Oropeza, MD — 2022-10-6
Satoko Kumada #1
Satoko Kumada
Tokyo Metropolitan Neurological Hospital, Tokyo, Japan | Department of Neuropediatrics, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan | Department of Neuropediatrics, ...
Magnetic Resonance | Alcohol Spectrum | Brain Regions | Pfas Groups | Fasd 4digit Code
Emi Kasai‐Yoshida #2
Emi Kasai‐Yoshida
Departments of Neuropediatrics and | Departments of Pediatrics and | Department of Neuropediatrics, Tokyo Metropolitan Neurological Hospital, 2-6-1 Musashidai, Fuchu, Tokyo ...
Magnetic Resonance | Alcohol Spectrum | Brain Regions | Pfas Groups | Fasd 4digit Code
Kenji Sugai #3
Kenji Sugai
4Department of Child Neurology, National Center Hospital, NCNP, Kodaira, Tokyo. | Clinical Department, Soleil Kawasaki Medical Center for the Handicapped, Kawasaki, Japan | ...
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Yasuhiro Nakata #4
Yasuhiro Nakata
Department of Neuroradiology, Tokyo Metropolitan Neurological Hospital, 2-6-1 Musashidai, Fuchu, Tokyo 183-0042, Japan. | Department of Neuroradiology, Tokyo Metropolitan ...
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Ikuko Sato‐Shirai #5
Ikuko Sato‐Shirai
Department of Neuropediatrics, Tokyo Metropolitan Neurological Hospital, Japan; Department of Pediatrics, Tokyo Metropolitan Fuchu Ryoiku Center, Japan. Electronic address: ...
Magnetic Resonance | Alcohol Spectrum | Brain Regions | Pfas Groups | Fasd 4digit Code
Kimiteru Ito #6
Kimiteru Ito
Department of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan | Department of Diagnostic Radiology, National Cancer Center Hospital, Tokyo, Japan. | ...
Magnetic Resonance | Alcohol Spectrum | Brain Regions | Pfas Groups | Fasd 4digit Code
Hideharu Sugimoto #7
Hideharu Sugimoto
Department of Radiology School of Medicine, Jichi Medical University and Hospital, Tochigi 329-0498, Japan | Department of Radiology, Jichi Medical University, School of ...
Magnetic Resonance | Alcohol Spectrum | Brain Regions | Pfas Groups | Fasd 4digit Code
Shinsuke Maruyama #8
Shinsuke Maruyama
Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry (NCNP), Tokyo, Japan | Child Neurology, National Center of Neurology and ...
Magnetic Resonance | Alcohol Spectrum | Brain Regions | Pfas Groups | Fasd 4digit Code
Konomi Shimoda #9
Konomi Shimoda
Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan | Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, ...
Magnetic Resonance | Alcohol Spectrum | Brain Regions | Pfas Groups | Fasd 4digit Code
Yasuo Hachiya #10
Yasuo Hachiya
Department of Neuropediatrics, Tokyo Metropolitan Neurological Hospital, Fuchu, Tokyo 183-0042, Japan | Department of Neuropediatrics, Tokyo Metropolitan Neurological ...
Magnetic Resonance | Alcohol Spectrum | Brain Regions | Pfas Groups | Fasd 4digit Code
Akira Yagishita #11
Akira Yagishita
Department of Neuroradiology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan. | Tokyo Metropolitan Neurological Hospital Department of Neuroradiology Tokyo Japan | ...
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Yukio Kimura #12
Yukio Kimura
From the Departments of Radiology (H.F., N.Sato, Y.K., M.K., E.C., Y.S.). | Department of Radiology, National Center Hospital, National Center of Neurology and Psychiatry, ...
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Kouhei Kamiya #13
Kouhei Kamiya
Department of Diagnostic Radiology, Toho University Omori Medical Center | Department of Radiology, Juntendo University School of Medicine, Tokyo, Japan | Department of ...
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Eiji Kurihara #14
Eiji Kurihara
Department of Neuropediatrics, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan | Tokyo Metropolitan Neurological Hospital Department of Neuropediatrics Tokyo Japan | ...
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Kiyomi Nishiyama #15
Kiyomi Nishiyama
Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama, Japan | Yokohama City University Department of Human Genetics Graduate School of ...
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Taki Nishimura #16
Taki Nishimura
PRESTO, Japan Science and Technology Agency, Chiyoda-ku, Tokyo 102-0076, Japan | Department of Biochemistry and Molecular Biology, Graduate School and Faculty of Medicine, The ...
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Yukiko Kondo #17
Yukiko Kondo
Department of Human Genetics, Yokohama City University Graduate School of Medicine, Yokohama 236-0004, Japan | Yokohama City University Graduate School of Medicine Department ...
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Michael C Kruer #18
Michael C Kruer
Barrow Neurological Institute, Phoenix Children's Hospital; Child Health, Neurology & Genetics, University of Arizona College of Medicine, Phoenix, Arizona | Barrow ...
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Akihiro Hoshino #19
Akihiro Hoshino
Laboratory of Lymphocyte Activation and Susceptibility to EBV Infection, INSERM UMR 1163, Imagine Institute, Paris, France | Department of Developmental Medical Sciences, ...
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Fukiko Ryujin #20
Fukiko Ryujin
Department of Pediatrics, Shiga University of Medical Science, Otsu, Japan. | Department of Pediatrics, Shiga University of Medical Science, Shiga, Japan
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Mri, Mr Spectroscopy, And Diffusion Tensor Imaging Findings In Patient With...

Static encephalopathy of childhood with neurodegeneration in adulthood (SENDA) is a recently established disorder that is a subtype of neurodegeneration with brain iron accumulation (NBIA). We ...

Static Encephalopathy | Diffusion Tensor | Childhood Neurodegeneration | Imaging Findings | Adulthood Senda

De Novo Mutations In The Autophagy Gene Wdr45 Cause Static Encephalopathy Of...

.. cause static encephalopathy of childhood with neurodegeneration in adulthood. WDR45 encodes a homolog of the yeast autophagy protein Atg18.

Novo Mutations | Static Encephalopathy | Autophagy Gene | Wdr45 Encodes | Intellectual Disability

First Video Report Of Static Encephalopathy Of Childhood With Neurodegeneration...

Static Encephalopathy | Video Report | Childhood Neurodegeneration | Neurodegenerative Diseases

Delayed-Onset Dystonia In Patients With "static" Encephalopathy.

Eight cases of persistent dystonia appearing one to 14 years after non-progressive cerebral insults are described. Five were due to perinatal anoxia, one to trauma, and two to cerebral ...

Static Encephalopathy | Onset Dystonia | Cerebral Infarction | Brain Injuries | Female Fetal

Course Of Schizophrenia: Neuropsychological Evidence For A Static Encephalopathy.

.. a static encephalopathy. Review of longitudinal and cross-sectional studies strongly supports the latter interpretation. In particular, we present data from a recent cross-sectional study ...

Neuropsychological Evidence | Static Encephalopathy | Cognitive Function | Tests Schizophrenia | Crosssectional Study

Memory And Intellectual Deficits Do Not Decline With Age In Schizophrenia

.. a static encephalopathy than a dementing disorder. This study investigates memory and intellectual decline in 62 chronic schizophrenic subjects using the Wechsler Adult Intelligence ...

Intellectual Deficits | Age Schizophrenia | Static Encephalopathy | Memory Disorders | Crosssectional Study

Syndromes Of Neurodegeneration With Brain Iron Accumulation

In parallel to recent developments of genetic techniques, understanding of the syndromes of neurodegeneration with brain iron accumulation has grown considerably. The acknowledged clinical ...

Brain Iron Accumulation | Static Encephalopathy | Parkinson Disease | Neurodegeneration Adulthood | Clinical Findings

Is There Cognitive Decline In Schizophrenia?

The issue of progressive cognitive decline in patients with schizophrenia has been debated. We performed a cross-sectional study of patients with chronic schizophrenia, aged from 18 to 69 ...

Cognitive Decline | Patients Schizophrenia | Neuropsychological Tests | Static Encephalopathy | Progressive Dementia

A Review Of Longitudinal Studies Of Cognitive Function In Schizophrenia Patients.

Even though the idea that schizophrenia is a neurobehavioral syndrome has become a mainstream position, there is no consensus on the precise nature of the cognitive and neuropsychological ...

Longitudinal Studies | Cognitive Function | Neuropsychological Tests | Schizophrenia Question | Degenerative Process

Management Of Status Dystonicus: Our Experience And Review Of The Literature

.. with static encephalopathy, and the other one in a patient with pantothenate kinase-associated neurodegeneration. Both patients were admitted to an intensive care unit and treated with ...

Status Dystonicus | Intensive Unit | Static Encephalopathy | Acute Worsening | Data Literature

Age And Neuropsychologic Function In Schizophrenia: A Decline In Executive...

.. a static encephalopathy or a deterioration of brain function, or periods of each condition. Assessments of cognitive function, as measured by neuropsychologic assessment, can provide ...

Patients Schizophrenia | Executive Functions | Cognitive Function | Age Effects | Aging Brain

Analysis Of The C19orf12 And Wdr45 Genes In Patients With Neurodegeneration With...

.. named static encephalopathy in childhood with neurodegeneration in adulthood (also called BPAN); however, analysis of this gene in a broader spectrum of NBIA has not been reported yet.

Brain Iron Accumulation | Wdr45 Gene | Heterozygote Humans | Mutations C19orf12 | Static Encephalopathy

3-Methyl Glutaconic Aciduria In Iraqi Jewish Children May Be Misdiagnosed As...

.. a static encephalopathy causing a non-progressive disorder of posture and/or movement. We describe 7 patients from 5 families who were initially diagnosed with cerebral palsy. Eventually, ...

Cerebral Palsy | Static Encephalopathy | Nonprogressive Disorder | Inborn Errors | Diagnosis Differential

Neurocognitive Impairment Across The Lifespan In Schizophrenia: An Update

A literature review and power analysis of longitudinal studies published since 1997 investigating the trajectory of neurocognitive deficits across time in patients with schizophrenia was ...

Patients Schizophrenia | Neurocognitive Impairment | Longitudinal Studies | Cognitive Measures | Literature Review

Tonic–absence Seizures: An Underrecognized Seizure Type

PURPOSE: The individual electroclinical patterns--tonic seizures with generalized paroxysmal fast activity (GPFA, activity >13 Hz), and absence seizures with generalized slow spike-and-wave ...

Absence Seizures | Generalized Epilepsy | Seizure Type | Activity Gpfa | Patients Age

Functional Magnetic Resonance Imaging Outcomes From A Comprehensive Magnetic...

.. 2. Static Encephalopathy/Alcohol Exposed (SE/AE); 3. Neurobehavioral Disorder/Alcohol Exposed (ND/AE); and 4. healthy peers with no prenatal alcohol exposure. fMRI outcomes are reported ...

Alcohol Spectrum | Magnetic Resonance | Brain Regions | Imaging Outcomes | Fmri Children

Neuropyschological And Behavioral Outcomes From A Comprehensive Magnetic...

BACKGROUND: Clinical and research advancements in the field of fetal alcohol spectrum disorders (FASD) require accurate and valid identification of FASD clinical subgroups.

OBJECTIVES: A ...

Alcohol Spectrum | Resonance Study | Comprehensive Magnetic | Disorders Fasd | Mri Fmri

Magnetic Resonance Spectroscopy Outcomes From A Comprehensive Magnetic Resonance...

.. (2) static encephalopathy/alcohol exposed (SE/AE); (3) neurobehavioral disorder/alcohol exposed (ND/AE) as diagnosed with the FASD 4-Digit Code; and (4) healthy peers with no prenatal alcohol exp

Magnetic Resonance | Alcohol Spectrum | Study Groups | Corpus Callosum | White Matter

Magnetic Resonance Imaging Outcomes From A Comprehensive Magnetic Resonance Study...

.. (ii) static encephalopathy/alcohol exposed (SE/AE); (iii) neurobehavioral disorder/alcohol exposed (ND/AE) as diagnosed with

Magnetic Resonance | Alcohol Spectrum | Brain Regions | Pfas Groups | Fasd 4digit Code
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