Jeffrey A. M.D. Lieberman

Jeffrey A. M.D. Lieberman

Feinstein Institute For Medical Research, Manhasset (Drs Malhotra, Correll, Gregersen, Lee, Kane, And Lencz), Zucker Hillside Hospital, Glen Oaks (Drs Malhotra, Correll, Kane, ...

Direct Impact

Concepts for which Jeffrey A M D Lieberman has direct influence:

tardive dyskinesia
weight gain
first-episode schizophrenia
antipsychotic drugs
schizoaffective disorder
clozapine response
untreated psychosis

External impact

Concepts related to the work of other authors for which Jeffrey A M D Lieberman has influence:

whole-exome sequencing
bipolar disorder
sub-genic intolerance
tardive dyskinesia
weight gain
chronic schizophrenia
violent content

Prominent publications by Jeffrey A. M.D. Lieberman

KOL-Index: 237 Extreme phenotype sequencing has led to the identification of high-impact rare genetic variants for many complex disorders but has not been applied to studies of severe schizophrenia. We sequenced 112 individuals with severe, extremely treatment-resistant schizophrenia, 218 individuals with typical schizophrenia, and 4,929 controls. We compared the burden of rare, damaging missense and ...
Known for
Schizophrenia Typical | Rare Loss | Genes Odds | Damaging
KOL-Index: 125 These updated guidelines are based on a first edition of the World Federation of Societies of Biological Psychiatry Guidelines for Biological Treatment of Schizophrenia published in 2005. For this 2012 revision, all available publications pertaining to the biological treatment of schizophrenia were reviewed systematically to allow for an evidence-based update. These guidelines provide ...
Known for
Societies Biological | 2012 Acute | Schizophrenia Management
KOL-Index: 102 Various criteria used to define atypical antipsychotic drugs include: 1) decrease, or absence, of the capacity to cause acute extrapyramidal motor side effects (acute EPSE) and tardive dyskinesia (TD); 2) increased therapeutic efficacy reflected by improvement in positive, negative, or cognitive symptoms; 3) and a decrease, or absence, of the capacity to increase prolactin levels. The ...
Known for
Absence Capacity | Extrapyramidal Motor | Drugs Clozapine | Action Atypical
KOL-Index: 101 The CNV analysis group of the Psychiatric Genomic Consortium analyzes a large schizophrenia cohort to examine genomic copy number variants (CNVs) and disease risk. They find an enrichment of CNV burden in cases versus controls and identify 8 genome-wide significant loci as well as novel suggestive loci conferring either risk or protection to schizophrenia.
Known for
Enrichment | Protection | Genomic Copy Number | 8 Genome-Wide Loci
KOL-Index: 89 Since the discovery of chlorpromazine in the 1950's, antipsychotic drugs have been the cornerstone of treatment of schizophrenia, and all attenuate dopamine transmission at the dopamine-2 receptor. Drug development for schizophrenia since that time has led to improvements in side effects and tolerability, and limited improvements in efficacy, with the exception of clozapine. However, the ...
Known for
Reasons Clozapine | Receptor Drug | Future Dopamine-2
KOL-Index: 79 These updated guidelines are based on the first edition of the World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia published in the years 2005 and 2006. For this 2015 revision, all available publications pertaining to the biological treatment of schizophrenia were reviewed systematically to allow for an evidence-based update. ...
Known for
Identified Literature | Pharmacological Options | Schizophrenia Update | Evidence-Based Recommendations
KOL-Index: 68 We report on the rationale and design of an ongoing NIMH sponsored R61-R33 project in schizophrenia/schizoaffective disorder. This project studies augmenting the efficacy of auditory neuroplasticity cognitive remediation (AudRem) with d-serine, an N-methyl-d-aspartate-type glutamate receptor (NMDAR) glycine-site agonist. We operationalize improved (smaller) thresholds in pitch (frequency) ...
Known for
Open Question | Audrem Improved | 45 Schizophrenia | Mmn Auditory
KOL-Index: 68 These guide lines for the biological treatment of schizophrenia were developed by an international Task Force of the World Federation of Societies of Biological Psychiatry (WFSBO). The goal during the development of these guidelines was to review systematically all available evidence pertaining to the treatment of schizophrenia, and to reach a consensus on a series of practice ...
Known for
Acute Schizophrenia | Federation Societies | Pharmacological Biological
KOL-Index: 68 Larger CAG/CTG trinucleotide-repeat tracts in individuals affected with schizophrenia (SCZ) and bipolar affective disorder (BPAD) in comparison with control individuals have previously been reported, implying a possible etiological role for trinucleotide repeats in these diseases. Two unstable CAG/CTG repeats, SEF2-1B and ERDA1, have recently been cloned, and studies indicate that the ...
Known for
Cag Ctg | Highly Polymorphic Trinucleotide Repeat | Bipolar Affective Disorder | Alleles Bpad
KOL-Index: 54 The study of psychoneuroendocrinology of schizophrenia has yielded an extensive but inconclusive body of data. Investigations to date have been limited by several factors, including the confounding effects of neuroleptic drugs, methodological limitations, and lack of appreciation for the heterogeneity of the illness. Previously, the focus of research has been on the measurement of anterior ...

Feinstein Institute for Medical Research, Manhasset (Drs Malhotra, Correll, Gregersen, Lee, Kane, and Lencz), Zucker Hillside Hospital, Glen Oaks (Drs Malhotra, Correll, Kane, and Lencz), and New York State Psychiatric Institute/Columbia University,

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