• Disease
  • Type
  • Type 2
  • Type 2 Diabetes
  • Hajime Izumiyama

    Prominent publications by Hajime Izumiyama

    KOL Index score: 14690

    BACKGROUND: Abdominal visceral obesity has been reported to be associated with cardiovascular risks than body mass index, waist circumference, and abdominal subcutaneous fat. On the other hand, there is evidence that subcutaneous fat has a beneficial role against cardio-metabolic risks such as diabetes or dyslipidemia. However, little is known regarding the association between high visceral fat with low subcutaneous fat accumulation and the risk for atherosclerosis.

    METHODS: This study ...

    Also Ranks for: Visceral Fat |  type 2 diabetes |  atherosclerosis patients |  vfa ≥ |  2 female
    KOL Index score: 13361

    OBJECTIVE: Differential expression of several genes between ACTH-secreting pituitary tumors causing Cushing' disease (CD), silent corticotroph adenoma (SCA), and non-functioning pituitary tumors (NFT) was investigated.

    DESIGN AND METHODS: We used tissue specimens from 35 pituitary tumors (12 CD, 8 SCA, and 15 NFT). Steady-state mRNA levels of the genes related to proopiomelanocortin (POMC) transcription, synthesis, processing, and secretion, such as neurogenic differentiation 1 ...

    Also Ranks for: Gene Expression |  sca nft |  messenger receptors |  functioning pituitary |  acth secreting
    KOL Index score: 12038

    BackgroundAccumulation of epicardial fat (EF) is associated with increased cardio-metabolic risks and coronary events, independently of traditional cardiovascular risk factors. Therefore, the reduction of EF volume (EFV) may be associated with reduced cardio-metabolic risks and future cardiovascular events. Sodium-glucose co-transporter-2 (SGLT2) inhibitors reduce body fat including visceral fat and cardiovascular events in patients with type 2 diabetes. However, it has still been ...

    Also Ranks for: Type 2 |  epicardial fat |  luseogliflozin treatment |  vfa lai |  body weight bmi
    KOL Index score: 11052

    The purpose of this study was to examine whether periodontal treatment incorporating topical antibiotic therapy affects on levels of glycohemoglobin (HbA1c) and serum high-sensitivity C-reactive protein (hs-CRP) in type 2 diabetic patients with periodontal disease, and to explore the relationship between CRP and glycemic control. The whole intervention group (n=32), which underwent anti-infectious periodontal treatment, showed only transient reduction in HbA1c levels without any change ...

    Also Ranks for: Periodontal Treatment |  type 2 |  diabetic patients |  reduction hba1c |  intervention study
    KOL Index score: 10659

    BACKGROUND: Whole body dual-energy X-ray absorptiometry (DXA) can simultaneously measure both regional fat and non-fat mass. Android-to-gynoid (A/G) ratio measured by DXA has been reported to be associated with cardiovascular risks and visceral adiposity; however, little is known regarding its relationship with fatty liver disease and atherosclerosis among patients with diabetes. This study was designed to investigate the association of android and gynoid fat mass measured by DXA with ...

    Also Ranks for: Type 2 |  fatty liver |  fat mass |  ray absorptiometry |  vfa lai
    KOL Index score: 10547

    OBJECTIVE: Among indirect measures of visceral adiposity, A Body Shape Index (ABSI), which is defined as waist circumference (WC)/(body mass index (BMI)(2/3)×height(1/2)), is unique in that ABSI is positively correlated with visceral adiposity and is supposed to be independent of BMI. ABSI has been also shown to be linearly and positively associated with visceral fat mass and all-cause and cardiovascular disease (CVD) in the general population. It is, however, uncertain whether ABSI ...

    Also Ranks for: Arterial Stiffness |  visceral adiposity |  type 2 diabetes |  bmi absi |  body shape
    KOL Index score: 10203

    Sarcopenia is defined as an age-related loss of skeletal muscle mass and strength, and is a major cause of disability and mobility limitations. Recent studies have demonstrated that type 2 diabetes and insulin signaling deficiencies contribute to the progression of sarcopenia, suggesting that a sufficient supply of insulin to the skeletal muscles may be important for the maintenance of muscle function; however, little has been reported regarding whether insulin treatment can protect ...

    Also Ranks for: Insulin Treatment |  type 2 diabetes |  muscle mass |  sarcopenia patients |  grip strength
    KOL Index score: 9603

    Liraglutide, an analogue of human glucagon-like peptide 1, reduces cardiovascular events in patients with type 2 diabetes; however, it has still been unknown by which mechanisms liraglutide could reduce cardiovascular events. Type 2 diabetic patients with insulin treatment were enrolled in this randomized, open-label, comparative study. Participants were randomly assigned to liraglutide plus insulin (liraglutide group) and insulin treatment (control group) at 1:1 allocation. Primary ...

    Also Ranks for: Type 2 |  visceral fat |  hepatic steatosis |  liraglutide treatment |  cardiovascular events
    KOL Index score: 9466

    AIMS/INTRODUCTION: To investigate whether the ratio of visceral fat area (VFA) to subcutaneous fat area (SFA; V/S ratio) could be predictive of cardiovascular disease (CVD) as compared with VFA or SFA in patients with diabetes.

    MATERIALS AND METHODS: A total of 682 patients with type 2 diabetes (mean age 64 ± 13 years; 41% women) were enrolled. VFA (cm2 ) and SFA (cm2 ) were assessed by a dual bioelectrical impedance analyzer. The patients were divided into four groups according to the ...

    Also Ranks for: Type 2 Diabetes |  vfa sfa |  subcutaneous fat |  cardiovascular events |  cvd patients
    KOL Index score: 9195

    AIM: Endothelial dysfunction is considered an early event in the development of atherosclerosis. The present study was undertaken to determine whether the accumulation of cardiovascular risk factors and insulin resistance are associated with endothelial function in diabetic patients.

    METHODS: 101 patients with type 2 diabetes without macroangiopathy stratified by the number of cardiovascular risk factors (dyslipidemia, hypertension, obesity) and 9 normal control subjects were studied for ...

    Also Ranks for: Insulin Resistance |  endothelial dysfunction |  diabetic patients |  type 2 endothelium |  cardiovascular risk factors
    KOL Index score: 8868

    Measurement of late-night and/or midnight salivary cortisol currently used in US and European countries is a simple and convenient screening test for the initial diagnosis of Cushing's syndrome (CS). Unfortunately, this test has not been widely used in Japan. The purpose of this study was to evaluate the usefulness of the measurement of late-night salivary cortisol as a screening test for the diagnosis of CS in Japan. We studied 27 patients with various causes of CS, consisting of ...

    Also Ranks for: Salivary Cortisol |  screening test |  normal subjects |  cushings syndrome |  diagnosis cushing
    KOL Index score: 8734

    OBJECTIVES: Chronic inflammation of periodontitis aggravates glycemic control in type 2 diabetic patients through aggravation of insulin resistance. Increased or decreased release of various inflammatory mediators, such as high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor (TNF)-α, interleukin (IL)-6 and adipokines, such as adiponectin, leptin, and resistin, are presumed to be responsible for developing and progressing insulin resistance. The purpose of this study was to ...

    Also Ranks for: Periodontal Treatment |  glycemic control |  type 2 |  insulin resistance |  adiponectin patients
    KOL Index score: 8733

    A 75-year-old woman was admitted to our hospital because of a poor glycemic control. She was found to have Cushingoid feature and dynamic endocrine tests showed elevated plasma ACTH and cortisol levels, lack of their circadian rhythm, non-suppressibility to high-dose dexamethasone, responsiveness to CRH, but not to DDAVP, and suppression to octreotide. Pituitary MRI showed an equivocal small lesion. CT scan of the chest showed two nodular lesions in the right lung (S5, S7), while a mild ...

    Also Ranks for: Ectopic Acth Syndrome |  carcinoid tumor |  cushing disease |  fluorodeoxyglucose f18 |  cortisol levels
    KOL Index score: 8006

    Primary aldosteronism (PA), an autonomous aldosterone hypersecretion from adrenal adenoma and/or hyperplasia, and subclinical Cushing syndrome (SCS), a mild but autonomous cortisol hypersecretion from adrenal adenoma without signs or symptoms of Cuhing's syndrome, are now well-recognized clinical entities of adrenal incidentaloma. However, the clinicopathological features of PA associated with SCS (PA/SCS) remain unknown. The present study was undertaken to study the prevalence of PA/SCS ...

    Also Ranks for: Pa Scs |  primary aldosteronism |  adrenal adenoma |  subclinical cushing |  aldosterone hypersecretion
    KOL Index score: 7880

    Flow-mediated vasodilatation (FMD) is a vascular functional test to detect endothelial dysfunction at the early stage of cardiovascular diseases. Patients with active acromegaly have higher morbidity and mortality due to cardiovascular events. To determine whether active acromegaly is associated with endothelial dysfunction, we studied 17 patients with active acromegaly for measurements of FMD, carotid intima-media thickness (IMT) and brachial-ankle pulse wave velocity (baPWV), and other ...

    Also Ranks for: Endothelial Dysfunction |  active acromegaly |  fmd patients |  insulin growth |  cardiovascular diseases


    Hajime Izumiyama: Influence Statistics

    Sample of concepts for which Hajime Izumiyama is among the top experts in the world.
    Concept World rank
    characteristics isolation discovery #3
    prosalusin variety #3
    salusinβ peptide #3
    positive acth immunoreactivity #3
    unprocessed biologically #3
    unidentified ligands characteristics #3
    6 scas data #3
    isoforms acth #3
    sca lead #3
    inactive pomc #3
    preferential production sca #3
    sca neoplastic humans #3
    nfas immunohistochemical study #3
    bioactivity salusinβ #3
    parasympathomimetic actions attempts #3
    salusins contrasting activities #3
    remaining nfa #3
    pomc sca #3
    acth nfa #3
    physicochemical property polypropylene #3
    clinical endocrine feartures #3
    6 scas #3
    bioactivity salusin #3
    193 salusins #3
    chapter 193 salusins #3
    antiacth antibody differences #3
    salusins discovered #3
    potent hemodynamic effects #3
    presence salusins #3
    88 skin pigmentation #4
    hypersecretion pa #4
    corticotroph sca #4
    japan ectopic #4
    75 acth #4
    laterality avs #4
    skin pigmentation 88 #4
    hypersecretion skin #4
    occult unknown #4
    unknown eas #4
    hypokalemia 88 #4
    occult unknown eas #4
    pigmentation 88 #4
    avs laterality #4
    proven eas #4
    neurod1 ikzf1 #5
    eas neurod1 #5
    pomcrelated enzymes #5
    longterm treatment telmisartan #5
    cushingoid feature #5
    pc2 sstr2 #5

    Key People For Type 2 Diabetes

    Top KOLs in the world
    David Richard Matthews
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    Frank B Hu
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    David Matthew Nathan
    type 2 diabetes insulin resistance cardiovascular disease
    John B Buse
    type 2 diabetes insulin degludec cardiovascular outcomes
    Tuomilehto Tuomilehto
    type 2 diabetes blood pressure north karelia

    Hajime Izumiyama:Expert Impact

    Concepts for whichHajime Izumiyamahas direct influence:Type 2 diabetes,  Type 2,  Periodontal treatment,  Endothelial dysfunction,  Insulin treatment,  Visceral fat,  Visceral adiposity,  2 diabetes.

    Hajime Izumiyama:KOL impact

    Concepts related to the work of other authors for whichfor which Hajime Izumiyama has influence:Type 2 diabetes,  Primary aldosteronism,  Periodontal treatment,  Glycemic control,  Cushing syndrome,  Arterial stiffness,  Muscle mass.



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    Center for Medical Welfare and Liaison Services, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan. | Department of Molecular Endocrinology and Metabolism, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental U