Hajime Izumiyama

Hajime Izumiyama

From The Tokyo Medical And Dental University Medical Hospital (H.i., M. Shichiri), Department Of Clinical And Molecular Endocrinology (H.i., Y.h.), And Department Of ...

Direct Impact

Concepts for which Hajime Izumiyama has direct influence:

2 diabetes
visceral adiposity
endothelial dysfunction
ectopic acth syndrome
arterial stiffness
insulin resistance
skeletal muscle

External impact

Concepts related to the work of other authors for which Hajime Izumiyama has influence:

pituitary adenomas
obesity measures
central fat
waist circumference
primary hepatic gastrinoma
coronary artery
cortisol secretion

Prominent publications by Hajime Izumiyama

KOL-Index: 29 A 54-year-old man with type 2 diabetes was referred to our hospital for endocrine evaluation of acromegaly. Physical examination showed typical acromegalic features without Cushingoid features. Magnetic resonance imaging of the brain revealed the presence of a pituitary macroadenoma. Basal plasma levels of GH and insulin-like growth factor-I under fasting hyperglycemia (202 mg/dl) were ...
Known for
54-Year-Old | Hypothalamo-Pituitary-Adrenal Hpa Axis | Lh-Rh | Immunohistochemical Method
KOL-Index: 25 Primary aldosteronism (PA), an autonomous aldosterone hypersecretion from adrenal adenoma and/or hyperplasia, and subclinical Cushing syndrome (SCS), a mild but autonomous cortisol hypersecretion from adrenal adenoma without signs or symptoms of Cuhing's syndrome, are now well-recognized clinical entities of adrenal incidentaloma. However, the clinicopathological features of PA associated ...
Known for
Aldosteronism | Cushing Syndrome | Features Primary | Aldosterone Acth
KOL-Index: 24 The appropriate localization of gastrinoma is still difficult. We aimed to evaluate the diagnostic accuracy of selective arterial calcium injection (SACI) for localization of gastrinomas including multiple lesions. This retrospective study included ten patients with surgically proven gastrinomas (gastrinoma group) and six patients without any findings suggesting Zollinger-Ellison syndrome ...
Known for
Injection Test | 120 Seconds | Feeding Arteries | Responses Gastrinomas
KOL-Index: 24 OBJECTIVE: The pathophysiology of aldosterone-producing adenomas (APA) has been investigated intensively through genetic and genomic approaches. However, the role of epigenetics in APA is not fully understood. In the present study, we explored the relationship between gene expression and DNA methylation status in APA. METHODS: We conducted an integrated analysis of transcriptome and ...
Known for
Epigenetics | Expression Dna | Cpg Methylation | Up-Regulated Genes
KOL-Index: 24 BackgroundWeight loss, which is an effective method for reducing visceral fat, may cause a concomitant loss of skeletal muscle mass. The aim of this study was to elucidate the changes in visceral fat and skeletal muscle mass in response to diabetes treatment including weight control.MethodsFor 6 months we observed the changes in the body compositions of 72 Japanese patients with type 2 ...
Known for
Loss Skeletal | Cm2 Baseline | -Median | Greater Reductions
KOL-Index: 23 BACKGROUND: Abdominal visceral obesity has been reported to be associated with cardiovascular risks than body mass index, waist circumference, and abdominal subcutaneous fat. On the other hand, there is evidence that subcutaneous fat has a beneficial role against cardio-metabolic risks such as diabetes or dyslipidemia. However, little is known regarding the association between high visceral ...
Known for
Atherosclerosis Diabetes | 100 Male | S-V Cimt | Stepwise Procedure
KOL-Index: 21 AIMS/INTRODUCTION: To investigate whether the ratio of visceral fat area (VFA) to subcutaneous fat area (SFA; V/S ratio) could be predictive of cardiovascular disease (CVD) as compared with VFA or SFA in patients with diabetes. MATERIALS AND METHODS: A total of 682 patients with type 2 diabetes (mean age 64 ± 13 years; 41% women) were enrolled. VFA (cm2 ) and SFA (cm2 ) were assessed by a ...
Known for
Area Vfa | 64 ± | Ratio Point | R-R Intervals
KOL-Index: 21 Subclinical Cushing's syndrome (SCS), a subtle cortisol hypersecretion from an adrenal tumor, may be a common adrenal disease. However, the cardiovascular prognosis and the optimal surgical and conservative treatment in SCS remain elusive. The present study was undertaken to evaluate the prevalence of cardiovascular risk factors in 16 SCS cases, their relationships to cortisol secretory ...
Known for
Dyslipidemia Igt | Hypertension Impaired | Cardiovascular Decreased | Syndrome Scs
KOL-Index: 21 Insulinomas are the most common hormone-producing pancreatic neuroendocrine tumors (NETs), which are usually benign, solitary and small. We describe herein a patient with a giant insulinoma (>10 cm in diameter) with concomitant thyroid tumor as detected by Somatostatin receptor scintigraphy (SRS). A 50-year-old man presented hypoglycemic symptoms 20 years after the first detection of a ...
Known for
Hormone-Producing Pancreatic Neuroendocrine Tumors | Concomitant Thyroid Neoplasm | Somatostatin Receptor | Giant Insulinoma
KOL-Index: 20 The effects of centrally administered Angiotensin II (Ang II) on water and food intake in rodent models are well known. However, most studies have focused on the acute effects of intracranial Ang II. In the current study, we evaluated the effects of intracerebroventricular Ang II on food and water intake as well as locomotor activity over the entire dark phase of the murine diurnal cycle. ...
Known for
Decreased Cumulative Water | Murine Diurnal Cycle | Centrally Administered Ang | Spontaneous Physical Activity

From the Tokyo Medical and Dental University Medical Hospital (H.I., M. Shichiri), Department of Clinical and Molecular Endocrinology (H.I., Y.H.), and Department of Cardio-thoracic Surgery (H.T., K.E., M. Sunamori), Tokyo Medical and Dental Universi

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